Figures (2)  Tables (1)

    • Figure 1. 

      Pancreatic protocol CT scan showing pancreatic head lesion (marked in semicircular blue) causing dilatation of CBD. Lesion is placed between MPD (marked in linear blue) and CBD.

    • Figure 2. 

      Histopathology and immunohistochemistry of MINEN. a High power (×40) (H&E); tumor cells arranged in glandular pattern suggestive of adenocarcinoma component. b High power (×40) (H&E); tumor cells arranged in nesting pattern suggestive of NEN component. c Low power (×10); adenocarcinoma component of tumor strongly highlighted by PanCK immunohistochemistry marker. d Low power (×10); NEN component of tumor strongly highlighted by synaptophysin immunohistochemisty marker. e High power (×40); NEN component of tumor highlighted by chromogranin. f High power (×40); Ki 67 index <1%.

    • Genes common to NEN Genes common to nNEN Genes common to both
      ATRX ARID1A TP53
      RB1 PIK3CA Loss of heterozygosity
      CTNNB1 KRAS
      MYC BRAF
      APC
      PI3KCA
      MUTYH
      CHECK2
      BRCA2

      Table 1. 

      Genes involved in NEN and nNEN [4, 7, 9]