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Assignee Application number Main claims Expiration date CVC team CN201380038920.6 The genome editing system is composed of Cas9 and sgRNA. 2033-03-15 CN201710585690.5 The genome editing system is composed of Cas9 and sgRNA. 2033-03-15 Broad Institute team CN201380070567.X The vector system for Cas9 and gRNA is utilized in eukaryotic cells. 2033-12-12 Table 1.
Published patents of CRISPR-Cas9 and CRISPR-Cas12 systems in China.
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Assignee Application number Claims Expiration date Cas12b Institute of Zoology, Chinese Academy of Sciences, and Beijing Institute of Stem Cell and Regenerative Medicine CN202110591698.9 Cas12b variants 2040-12-07 chCas12b Fudan University CN202110606220.9 chCas12b (Cas12J-8) 2041-5-31 Cas12d/CasY Longping Biotechnology (Hainan) Co., Ltd. CN202310237362.1 CasD 2043-03-13 Cas12f/Cas14 Jilin Academy of Agricultural Sciences CN202210204370.1 CasF2 2042-03-03 Cas12f (cas12i3) China Agricultural University CN201980014560.3 Cas12f 2039-10-29 CN202110473640.4 Divisional Application, Under examination / CN202110473632.X Divisional Application 2039-10-29 Bellagen Biotechnology Co., Ltd. CN202210603607.3 Cas12i3 variants with S7R, Y124R mutations 2042-05-31 Bellagen Biotechnology Biotechnology Co., Ltd. CN202210314807.7 Cas12i3 variants with N417K, S638N mutations 2042-03-29 Bellagen Biotechnology Co., Ltd. CN202310088437.4 Cas12i3 variants with D233R, D267R, N369R, S433R mutations 2043-02-02 Bellagen Biotechnology Co., Ltd. CN202311039065.2 Fusion of Cas9-HNH with Cas12i3 2043-08-17 Cas12i China Agricultural University CN201980027152.1 Cas12i (Cas12i.1) protein and application 2039-04-19 Institute of Zoology, Chinese Academy of Sciences, and Beijing Institute of Stem Cell and Regenerative Medicine CN202011414384.3 Cas12i variants 2040-12-07 Cas12i12 HuiEdit Therapeutics Co., Ltd. CN202111290670.8 Under examination / Bellagen Biotechnology Co., Ltd. CN202310096173.7 Cas12i12 variants with G179R, N269R, Q445R, V447R, E492R, T632R, A825R mutations, under examination / Cas12j/Casφ China Agricultural University CN201980014005.0 Cas12j.19 2039-11-15 CN202110475316.6 Divisional Application of Cas12j.4 2039-11-15 CN202110475336.3 Divisional Application, under examination / Cas12j.19 Bellagen Biotechnology Co., Ltd. CN202310092231.9 Cas12j.19 variant with E100R mutation 2043-02-03 IscB HuidaGene Therapeutics Co., Ltd. CN202311617088.7 Novel IscB polypeptides and their applications 2043-11-30 TnpB Beijing Coveland Biological Science Co., Ltd. CN202311230195.4 Mini-TnpB after functional domain streamlining (less than 380 AA) 2043-09-22 Huazhong Agricultural University CN202310177144.3 TnpB identified from Archaea 2043-02-28 Gs12-7 Huazhong Agricultural University CN202310086152.7 Nucleic acid endonucleases with high activity and temperature tolerance 2043-01-17 Gs12-16/Gs12-18 Huazhong Agricultural University CN202310256014.9 Gs12-16 (PAM=NYYV), and Gs12-18 (PAM=YTYV) (V=A/C/G)(Y=C/T) 2043-03-16 Gs12-10 Huazhong Agricultural University CN202310006257.7 Gs12-10 nuclease without PAM restrictions 2043-01-02 Gs12-3/Gs12-5 Huazhong Agricultural University CN202310247616.8 Nucleases with a wider range of target sites 2043-03-10 CasD Longping Biotechnology (Hainan) Co., Ltd. CN202310237362.1 CasD nuclease with 5'-TNN PAM 2043-03-13 PaeCascade Sun Yat-sen University CN202010527709.2 Type I-F based CRISPR/Cas system 2040-06-11 Cascade-Cas3 China Pharmaceutical University CN202211136496.6 Type I-B CRISPR-Cascade-Cas3 2042-09-19 Table 2.
IP landscape of representative nucleases in China.
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Nuclease Origin Editor type PAM/TAM Species Ref. MAD7 (ErCas12a) Eubacterium rectale Knockout/CBE YTTN Rice, wheat, soybean, arabidopsis [86,100,101,113] FnCas12a Francisella novicida Knockout TTV Rice, maize, arabidopsis, Populus, tobacco, wheat [67,69,114−116] Lb5Cas12a Lachnospiraceae bacterium MA2020 Knockout TTTV Rice [86] BsCas12a Butyrivibrio sp. NC3005 Knockout VTTV Rice [86] MbCas12a Moraxella bovoculi Knockout TTTV Rice [86] Mb2Cas12a Moraxella bovoculi strain 57922 Knockout VTTV Rice and cotton [86,117,118] Mb2Cas12a-RVR Moraxella bovoculi strain 57922 Knockout TATV Rice [86] Mb3Cas12a Moraxella bovoculi AAX11 00205 Knockout NTTV Rice, maize, tomato [80] HkCas12a Helcococcus kunzii ATCC 51366 Knockout VTTV Rice [80] PrCas12a Pseudobutyrivibrio ruminis CF1b Knockout VTTV Rice [80] TsCas12a Thiomicrospira sp. XS5 Knockout TTTV Rice [86] AaCas12b Alicyclobacillus acidiphilus Knockout/CRISPRi/CRISPRa VTTV Rice [119] AacCas12b Alicyclobacillus acidoterrestris Knockout/CRISPRi/CRISPRa TTV Rice and cotton [119,120] BhCas12b Bacillus hisashii Knockout/CRISPRi/CRISPRa VTTV Rice [119] BthCas12b Bacillus thermoamylovorans Knockout/CRISPRi/CRISPRa ATTN Rice [119] BvCas12b Bacillus sp. V3-13 Knockout TTN Arabidopsis [121] BhCas12b v4 Bacillus hisashii variant Knockout TTN Arabidopsis [121] Cas12f Syntrophomonas palmitatica (Sp), Acidibacillus sulfuroxidans, and uncultured archaeon (Un1) Knockout TTTR Tobacco and rice [108,122,123] Cas12i3 (Cas-SF01) Lachnospiraceae bacterium Knockout NNTN Rice, pepper, soybean [90,104,124] CasΦ(Cas12j-2) Biggiephage Knockout/CRISPRa/Epigenome editor/CBE/ABE NTTV Arabidopsis, rice, tomato, tobacco, wheat, rye [91,107,108,125] Cas12j-SF05 Caudoviricetes Knockout TTN Rice [126] Cas12j-8 Biggiephage Knockout/CBE TTN Soybean and rice [109] TnpB-IsDra2 Deinococcus radiodurans Knockout/ABE/CRISPRa TTGAT Rice and arabidopsis [110−112,127] TnpB-IsYmu1 Youngiibacter multivorans Knockout TTGAT Rice [111,127] TnpB-IsAam1 Anoxybacillus amylolyticus Knockout TTTAA Rice [111,127] TnpB-IsDge10 Deinococcus geothermalis Knockout TTAT Rice [111] enIscB Biggiephage Knockout NWRRNA Rice [111] Table 3.
Representative novel nucleases for genome editing in plant.
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