Figures (3)  Tables (2)

    • Figure 1. 

      Intestinal delivery defect.

    • Figure 2. 

      Oral delivery and absorption.

    • Figure 3. 

      Several common film making methods and their advantages and disadvantages.

    • Type Immediate release Adhesive type Slow release adhesion type
      Area (cm2) 2–8 2–7 2–4
      Quality (g) 0.02–0.2 0.02–0.2 0.02–0.2
      Thickness (μm) 10–70 50–500 50–250
      Structure Monolayer Single/multilayer Multilayer
      Ingredients Water-soluble polymer Water-soluble polymer Low solubility polymer
      Part used Tongue Buccula Other parts of mouth
      Releasing time 60 s A few minutes Maximum 8–10 h
      Take effect Local/whole body Local/whole body Local/whole body

      Table 1. 

      Classification of different types of oral soluble films[7−9].

    • Purpose Frequent species Effect
      Plasticizer Glycerin, polyethylene glycol, propylene glycol Enhanced intermolecular crosslinking[51]
      Colorant Natural pigments, synthetic pigments Protect the substance[52]
      Condiment Citric acid, sucralose, xylitol The substance is protected to improve the bad odor carried by the substance itself[53]

      Table 2. 

      Film forming auxiliary materials and their functions.