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    • Drug Original use Mechanism Target cells in AD*
      Letrozole Breast cancer Aromatase inhibitor Neurons (excitatory/inhibitory)
      Irinotecan Colorectal cancer, pancreatic cancer Topoisomerase inhibitor Glial cells (astrocytes, microglia, OPCs)
      * This assignment is based on computational predictions from the CMap database in the study by Li et al., where each drug's transcriptomic profile significantly reversed the disease-associated signatures in the respective cell types[8].

      Table 1. 

      Rationale for the combination of letrozole and irinotecan.