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Figure 1.
R-loop structure and profiling methods. (a) Sketch map of R-loop. (b) Schematic diagram illustrating the resolution and strand-specificity provided by different R-loop mapping methods. Resolution is defined as the distance between the experimentally identified edges of R-loop fragments via isolation or labeling and their actual genomic boundaries. Strand-specificity refers to the orientation of an R-loop, which can be defined based on the sequence of the ssDNA strand or the hybrid DNA/RNA strand. (c) Diagrammatic representation of methodological strategies adopted by R-loop mapping methods.
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Figure 2.
Overview of R-loop profiling methods.
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