Short-term ocular outcomes of ultrasound cycloplasty with or without intravitreal conbercept in neovascular glaucoma

Parameters, mean ± SD (∆ mean ± SD)	Postop. 1 d	Postop. 1 week	Postop. 1 month	Postop. 3 months	p^trend
UCP group (n = 45)	34.33 ± 12.99^a (−6.67 ± 11.52)	24.11 ± 9.25^a (−17.12 ± 8.25)	27.60 ± 10.65^a (−13.55 ± 8.43)	31.53 ± 11.74^a (−10.14 ± 10.64)	< 0.001
UCP + VEGF group (n = 35)	34.14 ± 10.61^a (−11.741 ± 13.10)	24.13 ± 8.00^a (−21.80 ± 13.31)	26.45 ± 10.30^a (−19.28 ± 11.82)	27.27 ± 11.56^a (−18.42 ± 13.57)	< 0.001
T	1.81	1.84	2.39	2.80	−
p	0.075	0.070	0.020	0.007	−
UCP: Ultrasonic cycloplasty; IOP: Intraocular pressure; logMAR: Logarithm of the Minimum Angle of Resolution. p-values for continuous variables (age, IOP) were derived from independent samples t-tests; drug times and visual acuity from Mann-Whitney U test; sex and eye laterality from chi-square test.

Table 1.

Comparison of general preoperative information between the two groups.

Parameters	UCP group (n = 45)	UCP + anti-VEGF group (n = 35)	p
Age, mean ± SD (years)	62.81 ± 11.90	57.47 ± 14.77	0.085
Sex (male/female)	14/31	23/12	0.002
Eye (right/left)	23/22	17/18	0.822
IOP, mean ± SD (mmHg)	42.69 ± 9.14	45.89 ± 7.55	0.099
Visual acuity (logMAR), mean ± SD	3.00 (2.30, 3.00)	2.30 (1.70, 3.00)	0.026
Drug times	3.0 (3.0,3.0)	3.0 (3.0,3.0)	0.263
Between-group p-values were derived from independent samples t-tests on change scores from baseline, which were normally distributed at all time points. p for trend was derived from simple linear regression within each group. ^ap < 0.05 vs baseline: within-group paired t-tests for IOP at day 1 and week 1; Wilcoxon signed-rank tests for IOP at month 1 and month 3.

Table 2.

Comparison of intraocular pressure changes before, and after surgery between the two groups.

Visual acuity (logMAR) median (IQR), ∆ median (IQR)	Postop. 1 d	Postop. 1 week	Postop. 1 month	Postop. 3 months	p^trend
UCP group (n = 45)	3.00 (2.30, 3.00), 0 (0, 0)	3.00 (2.30, 3.00), 0 (0, 0)	3.00 (2.30, 3.00), 0 (0, 0)	3.00 (2.30, 3.00), 0 (0, 0)	< 0.001
UCP + VEGF group (n = 35)	2.30 (1.40, 3.00), 0 (0, 0)	2.00 (1.20, 2.70)^a, 0 (0, 0)	2.30 (1.40, 3.00), 0 (0, 0)	1.70 (0.00, 2.70)^a, −0.60 (−1.26, 0)	< 0.001
Z	0.72	2.49	1.08	2.09	−
p	0.472	0.013	0.281	0.037	−
Between-group p-values were derived from Mann-Whitney U tests on change scores from baseline (Δ = postoperative − preoperative). ^ap < 0.05 vs baseline: within-group Wilcoxon signed-rank tests.

Table 3.

Comparison of visual acuity changes before and after surgery between the two groups.

Parameters, median(IQR), ∆ median(IQR)	Postop. 1 d	Postop. 1 wk	Postop. 1 mo	Postop. 3 mo	P^trend
UCP group (n = 45)	3.0 (3.0, 3.0), 0 (0, 0)	3.0 (2.0, 3.0), 0 (0, 0)	2.0 (2.0, 3.0), 0 (−1, 0)^a	2.0 (2.0, 3.0), 0 (−1, 0)^a	< 0.001
UCP + VEGF group (n = 35)	3.0 (3.0, 3.0), 0 (0, 0)	3.0 (2.0, 3.0), 0 (−1, 0)^a	3.0 (2.0, 3.0), 0 (−1, 0)^a	2.5 (2.0, 3.0), -0.5 (−2, 0)^a	0.005
Z	−0.10	1.43	0.40	0.29	−
p	0.923	0.152	0.689	0.771	−
Between-group p-values were derived from Mann-Whitney U tests. p for trend was derived from simple linear regression within each group. ^ap < 0.05 vs baseline: within-group Wilcoxon signed-rank tests.

Table 4.

Comparison of drug times before and after surgery between the two groups.