Figures (0)  Tables (5)
    • Batch PTH concentration (CFU/dose) Pigs vaccinated (n) Challenge dose (MLD) Survivors (n) Diseased (n) Deaths (n) Evaluation
      Batch 1 1 × 109 5 1 3 2 2 Fail
      Batch 1 2 × 109 5 1 5 0 0 Pass
      Batch 1 3 × 109 5 1 5 0 0 Pass
      Control − 3 1 1 2 2 −
      Batch 2 1 × 109 5 1 3 2 2 Fail
      Batch 2 2 × 109 5 1 5 0 0 Pass
      Batch 2 3 × 109 5 1 5 0 0 Pass
      Control − 3 1 1 2 2 −
      Batch 3 1 × 109 5 1 3 2 2 Fail
      Batch 3 2 × 109 5 1 5 0 0 Pass
      Batch 3 3 × 109 5 1 5 0 0 Pass
      Control − 3 1 1 2 2 −

      Table 1. 

      MPD evaluation of paratyphoid component in pig's post-challenge.

    • Batch Animal Dose (per animal) Survivors/vaccinated (n)
      1 Guinea pig 2 5/5
      1 Pig 10 2/2
      2 Guinea pig 2 5/5
      2 Pig 10 2/2
      3 Guinea pig 2 5/5
      3 Pig 10 2/2

      Table 2. 

      Safety evaluation of V4AFD.

    • Group Pigs (n) ELISA positive/vaccinated (n) Positive (%)
      V4AFD batch 1 5 5/5 100
      V4AFD batch 2 5 5/5 100
      V4AFD batch 3 5 5/5 100
      Bivalent control 5 5/5 100
      Unvaccinated control 3 0/3 0

      Table 3. 

      ELISA efficacy at 21 d post-vaccination.

    • Group Animal Vaccine dose Survivors/challenged (n) Protection (%)
      V4AFD batch 1 Pig 1 5/5 100
      V4AFD batch 2 Pig 1 5/5 100
      V4AFD batch 3 Pig 1 5/5 100
      Bivalent control Pig 1 5/5 100
      Unvaccinated control Pig - 0/3 0

      Table 4. 

      Challenge efficacy.

    • Time point Group Pigs (n) ELISA positive/tested (n) Positive (%)
      Pre-vaccination Vaccinated 10 0/10 0
      Pre-vaccination Control 5 0/5 0
      21 d post Vaccinated 10 10/10 100
      21 d post Control 5 0/5 0
      3 months post Vaccinated 10 10/10 100
      3 months post Control 5 0/5 0
      6 months post Vaccinated 10 10/10 100
      6 months post Control 5 0/5 0

      Table 5. 

      Duration of immunity via ELISA.