| [1] |
Gildea E, Scales-Theobald E, Thompson J, Cook A, Forde K, et al. 2024. Development and validation of a quality of life and treatment satisfaction measure in canine osteoarthritis. |
| [2] |
Rychel JK. 2010. Diagnosis and treatment of osteoarthritis. |
| [3] |
Yao Q, Wu X, Tao C, Gong W, Chen M, et al. 2023. Osteoarthritis: pathogenic signaling pathways and therapeutic targets. |
| [4] |
Mukherjee A, Das B. 2024. The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis. |
| [5] |
Budsberg SC, Bartges JW. 2006. Nutrition and osteoarthritis in dogs: does it help? |
| [6] |
Carlisle C, Metzger BT, Tintle NL, Polley K, Jackson KH, et al. 2024. The effects of omega-3 supplementation on the omega-3 index and quality of life and pain scores in dogs. |
| [7] |
McCarthy G, O'Donovan J, Jones B, McAllister H, Seed M, et al. 2007. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. |
| [8] |
Zhu W, Tang H, Cao L, Zhang J, Li J, et al. 2022. Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway. |
| [9] |
Sirše M. 2022. Effect of dietary polyphenols on osteoarthritis—molecular mechanisms. |
| [10] |
Dämmrich K. 1991. Relationship between nutrition and bone growth in large and giant dogs. |
| [11] |
Tiet T, Alman B. 2003. Developmental pathways in musculoskeletal neoplasia: involvement of the indian hedgehog-parathyroid hormone-related protein pathway. |
| [12] |
Parker VJ, Rudinsky AJ, Chew DJ. 2017. Vitamin D metabolism in canine and feline medicine. |
| [13] |
Zafalon RVA, Risolia LW, Pedrinelli V, Vendramini THA, Rodrigues RBA, et al. 2020. Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism. |
| [14] |
Di Nicola V. 2020. Degenerative osteoarthritis a reversible chronic disease. |
| [15] |
Roitner M, Klever J, Reese S, Meyer-Lindenberg A. 2024. Prevalence of osteoarthritis in the shoulder, elbow, hip and stifle joints of dogs older than 8 years. |
| [16] |
Enomoto M, de Castro N, Hash J, Thomson A, Nakanishi-Hester A, et al. 2024. Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs. |
| [17] |
Johnston SA. 1997. Osteoarthritis: Joint anatomy, physiology, and pathobiology. |
| [18] |
Sophia Fox AJ, Bedi A, Rodeo SA. 2009. The basic science of articular cartilage: structure, composition, and function. |
| [19] |
Jerosch J. 2011. Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially Omega‐3 fatty acids. |
| [20] |
Messina OD, Vidal Wilman M, Vidal Neira LF. 2019. Nutrition, osteoarthritis and cartilage metabolism. |
| [21] |
Clark KL. 2007. Nutritional considerations in joint health. |
| [22] |
Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, et al. 2005. Nutraceutical therapies for degenerative joint diseases: a critical review. |
| [23] |
Thomas S, Browne H, Mobasheri A, Rayman MP. 2018. What is the evidence for a role for diet and nutrition in osteoarthritis? |
| [24] |
Heinegård D, Saxne T. 2011. The role of the cartilage matrix in osteoarthritis. |
| [25] |
Zivkovic AM, Telis N, German JB, Hammock BD. 2011. Dietary omega-3 fatty acids aid in the modulation of inflammation and metabolic health. |
| [26] |
Zeng J, Franklin DK, Das A, Hirani V. 2023. The effects of dietary patterns and food groups on symptomatic osteoarthritis: A systematic review. |
| [27] |
Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. |
| [28] |
Liu CF, Samsa WE, Zhou G, Lefebvre V. 2017. Transcriptional control of chondrocyte specification and differentiation. |
| [29] |
Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, et al. 2005. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. |
| [30] |
Tetlow LC, Adlam DJ, Woolley DE. 2001. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. |
| [31] |
Chen J, Long F. 2018. mTOR signaling in skeletal development and disease. |
| [32] |
del Río E. 2025. Rethinking Osteoarthritis Management: Synergistic Effects of Chronoexercise, Circadian Rhythm, and Chondroprotective Agents. |
| [33] |
McInnes IB, Schett G. 2011. The pathogenesis of rheumatoid arthritis. |
| [34] |
Thysen S, Luyten FP, Lories RJU. 2015. Targets, models and challenges in osteoarthritis research. Disease Models & Mechanisms 8:17−30 |
| [35] |
Xu C, Fang MY, Wang K, Liu J, Tai GP, et al. 2020. Discovery and development of inflammatory inhibitors from 2-phenylchromonone (flavone) scaffolds. |
| [36] |
Goldring MB, Marcu KB. 2009. Cartilage homeostasis in health and rheumatic diseases. |
| [37] |
Caola G. 2003. The Anatomy and Physiology of Diarthroses. |
| [38] |
Vincent T, Wann A. 2019. Mechanoadaptation: articular cartilage through thick and thin. |
| [39] |
Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M. 2012. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. |
| [40] |
Birlik A. 2023. Nutritional Supplements for Musculoskeletal Health. In Functional exercise anatomy and physiology for physiotherapists, ed. Kaya Utlu D. Cham: Springer. pp. 547−59 doi: 10.1007/978-3-031-27184-7_28 |
| [41] |
Lopez AN, Bazer FW, Wu G. 2024. Functions and metabolism of amino acids in bones and joints of cats and dogs. In Nutrition and Metabolism of Dogs and Cats, ed. Wu G. Cham, Switzerland: Springer. pp, 155−75 doi: 10.1007/978-3-031-54192-6_7 |
| [42] |
Andraskar K. 2024. Recent advances in the understanding and management of osteoarthritis: a comprehensive review. |
| [43] |
LaForge JM, Urso K, Day JM, Bourgeois CW, Ross MM, et al. 2023. Non-steroidal anti-inflammatory drugs: clinical implications, renal impairment risks, and AKI. |
| [44] |
Fujiki M, Shineha J, Yamanokuchi K, Misumi K, Sakamoto H. 2007. Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and -9 activities, and lameness in dogs with osteoarthritis. |
| [45] |
Devries MC, McGlory C, Bolster DR, Kamil A, Rahn M, et al. 2018. Leucine, not total protein, content of a supplement is the primary determinant of muscle protein anabolic responses in healthy older women. |
| [46] |
Norton LE, Layman DK. 2006. Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. |
| [47] |
Blees NR, Teunissen M, Dobenecker B, Prawitt J, Tryfonidou MA, et al. 2024. Collagen hydrolysates as nutritional support in canine osteoarthritis: a narrative review. |
| [48] |
AlRaddadi EA, Winter T, Aukema HM, Miller DW. 2019. Effects of various dietary supplements on inflammatory processes in primary canine chondrocytes as a model of osteoarthritis. Canadian Journal of Veterinary Research 83:206−17 |
| [49] |
Henrotin Y, Chevalier X, Herrero-Beaumont G, McAlindon T, Mobasheri A, et al. 2013. Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities. |
| [50] |
Djerbal L, Lortat-Jacob H, Kwok J. 2017. Chondroitin sulfates and their binding molecules in the central nervous system. |
| [51] |
Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, et al. 2016. Osteoarthritis. |
| [52] |
Gregory PJ, Fellner C. 2014. Dietary supplements as disease-modifying treatments in osteoarthritis: a critical appraisal. P & T 39:436−52 |
| [53] |
Gupta RC, Canerdy TD, Lindley J, Konemann M, Minniear J, et al. 2012. Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate. |
| [54] |
Calder PC. 2017. Omega-3 fatty acids and inflammatory processes: from molecules to man. |
| [55] |
Basil MC, Levy BD. 2016. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. |
| [56] |
Barden AE, Moghaddami M, Mas E, Phillips M, Cleland LG, et al. 2016. Specialised pro-resolving mediators of inflammation in inflammatory arthritis. |
| [57] |
Lorke M, Willen M, Lucas K, Schille JT, Lüder Ripoli F, et al. 2020. Effect of antioxidants, mitochondrial cofactors and omega-3 fatty acids on telomere length and kinematic joint mobility in young and old shepherd dogs - a randomized, blinded and placebo-controlled study. |
| [58] |
Roush JK, Dodd CE, Fritsch DA, Allen TA, Jewell DE, et al. 2010. Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. |
| [59] |
Burron S, Richards T, Krebs G, Trevizan L, Rankovic A, et al. 2024. The balance of n-6 and n-3 fatty acids in canine, feline, and equine nutrition: exploring sources and the significance of alpha-linolenic acid. |
| [60] |
Cobb CS, Ernst E. 2006. Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus. |
| [61] |
Eason CT, Adams SL, Puddick J, Romanazzi D, Miller MR, et al. 2018. Greenshell™ mussels: a review of veterinary trials and future research directions. |
| [62] |
Bello AE, Oesser S. 2006. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. |
| [63] |
Gencoglu H, Orhan C, Sahin E, Sahin K. 2020. Undenatured Type II Collagen (UC-II) in joint health and disease: a review on the current knowledge of companion animals. |
| [64] |
Musial C, Kuban-Jankowska A, Gorska-Ponikowska M. 2020. Beneficial Properties of Green Tea Catechins. |
| [65] |
Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM. 2002. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor κB activation by degradation of the inhibitor of nuclear factor kappaB. |
| [66] |
Akhtar N, Haqqi TM. 2011. Epigallocatechin-3-gallate suppresses the global interleukin-1β-induced inflammatory response in human chondrocytes. |
| [67] |
Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM. 2004. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 β-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. |
| [68] |
Kotha RR, Luthria DL. 2019. Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects. |
| [69] |
Zeng L, Yu G, Hao W, Yang K, Chen H. 2021. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. |
| [70] |
Chandran B, Goel A. 2012. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. |
| [71] |
Chen B, Li H, Ou G, Ren L, Yang X, et al. 2019. Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage. |
| [72] |
Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, et al. 2010. Biological actions of curcumin on articular chondrocytes. |
| [73] |
Tian B, Liu J. 2020. Resveratrol: a review of plant sources, synthesis, stability, modification and food application. |
| [74] |
Collins JA, Moots RJ, Clegg PD, Milner PI. 2015. Resveratrol and N-acetylcysteine influence redox balance in equine articular chondrocytes under acidic and very low oxygen conditions. |
| [75] |
Ememe MU, Abdullahi US, Sackey AKB, Ayo JO, Mshelia WP, Edeh RE. 2016. Effects of a joint supplement whose main components are resveratrol and hyaluronic acid on some biochemical parameters in aged lame horses. |
| [76] |
Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, et al. 2017. Cannabidiol: state of the art and new challenges for therapeutic applications. |
| [77] |
Burstein S. 2015. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry 23:1377−85 |
| [78] |
Mechoulam R, Peters M, Murillo-Rodriguez E, Hanuš L. 2007. Cannabidiol--recent advances. Chemistry & Biodiversit 4: 1678-92 |
| [79] |
Corsato Alvarenga I, MacQuiddy B, Duerr F, Elam LH, McGrath S. 2023. Assessment of cannabidiol use in pets according to a national survey in the USA. |
| [80] |
Palmoski MJ, Brandt KD. 1979. Effect of calcipenia on proteoglycan metabolism and aggregation in normal articular cartilage in vitro. |
| [81] |
Rhouma M, El-Warrak A, Troncy E, Beaudry F, Chorfi Y. 2013. Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs. Canadian journal of veterinary research [Revue canadienne de recherche veterinaire] 77:191−98 |
| [82] |
Martinez SE, Lillico R, Lakowski TM, Martinez SA, Davies NM. 2017. Pharmacokinetic analysis of an oral multicomponent joint dietary supplement (Phycox(®)) in dogs. |
| [83] |
Comblain F, Barthélémy N, Lefèbvre M, Schwartz C, Lesponne I, et al. 2017. A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis. |
| [84] |
Chen B, He Q, Chen C, Lin Y, Xiao J, et al. 2023. Combination of curcumin and catalase protects against chondrocyte injury and knee osteoarthritis progression by suppressing oxidative stress. |
| [85] |
Martello E, Bigliati M, Adami R, Biasibetti E, Bisanzio D, et al. 2022. Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial. |
| [86] |
Logerstedt DS, Ebert JR, MacLeod TD, Heiderscheit BC, Gabbett TJ, et al. 2022. Effects of and Response to Mechanical Loading on the Knee. |
| [87] |
Felson DT. 1996. Does excess weight cause osteoarthritis and, if so, why? |
| [88] |
Gilbert S, Langenbach A, Marcellin-Little DJ, Pease AP, Ru H. 2019. Stifle joint osteoarthritis at the time of diagnosis of cranial cruciate ligament injury is higher in Boxers and in dogs weighing more than 35 kilograms. |
| [89] |
Bland SD. 2000. Canine osteoarthritis and treatments: a review. |
| [90] |
Richardson DC, Schoenherr WD, Zicker SC. 1997. Nutritional Management of Osteoarthritis. |
| [91] |
Döring AK, Junginger J, Hewicker-Trautwein M. 2018. Cruciate ligament degeneration and stifle joint synovitis in 56 dogs with intact cranial cruciate ligaments: correlation of histological findings and numbers and phenotypes of inflammatory cells with age, body weight and breed. |
| [92] |
Littman MP, Goldstein RE, Labato MA, Lappin MR, Moore GE. 2006. ACVIM small animal consensus statement on Lyme disease in dogs: diagnosis, treatment, and prevention. |