[1]

Kim MJ, Moon Y, Tou JC, Mou B, Waterland NL. 2016. Nutritional value, bioactive compounds and health benefits of lettuce (Lactuca sativa L). Journal of Food Composition and Analysis 49:19−34

doi: 10.1016/j.jfca.2016.03.004
[2]

Yang X, Gil MI, Yang Q, Tomás-Barberán FA. 2022. Bioactive compounds in lettuce: highlighting the benefits to human health and impacts of preharvest and postharvest practices. Comprehensive Reviews in Food Science and Food Safety 21:4−45

doi: 10.1111/1541-4337.12877
[3]

Davis WV, Weber C, Wakefield H, Wechsler S. 2025. Vegetables and Pulses Outlook: April 2025. VGS-375. Economic Research Service Situation and Outlook Report, United States Department of Agriculture. 33 pp. https://ers.usda.gov/sites/default/files/_laserfiche/outlooks/111478/VGS-375.pdf?v=23426
[4]

Collier GF, Tibbitts TW. 1982. Tipburn of lettuce. In Horticultural Reviews, ed. Janick J. London: Palgrave Macmillan UK. pp. 49−65 doi: 10.1002/9781118060773.ch2
[5]

Jenni S, Hayes RJ. 2010. Genetic variation, genotype × environment interaction, and selection for tipburn resistance in lettuce in multi-environments. Euphytica 171:427−439

doi: 10.1007/s10681-009-0075-5
[6]

Barta DJ, Tibbitts TW. 2000. Calcium localization and tipburn development in lettuce leaves during early enlargement. Journal of the American Society for Horticultural Science 125:294−298

doi: 10.21273/jashs.125.3.294
[7]

Clarkson DT. 1984. Calcium transport between tissues and its distribution in the plant. Plant, Cell & Environment 7:449−456

doi: 10.1111/j.1365-3040.1984.tb01435.x
[8]

Hartz TK, Johnstone PR, Smith RF, Cahn MD. 2007. Soil calcium status unrelated to tipburn of romaine lettuce. HortScience 42:1681−1684

doi: 10.21273/hortsci.42.7.1681
[9]

Ashkar SA, Ries SK. 1971. Lettuce tipburn as related to nutrient imbalance and nitrogen composition. Journal of the American Society for Horticultural Science 96:448−452

doi: 10.21273/jashs.96.4.448
[10]

Barta DJ, Tibbitts TW. 1986. Effects of artificial enclosure of young lettuce leaves on tipburn incidence and leaf calcium concentration. Journal of the American Society for Horticultural Science 111:413−416

doi: 10.21273/jashs.111.3.413
[11]

Brumm I, Schenk M. 1993. Influence of nitrogen supply on the occurence of calcium deficiency in field grown lettuce. Acta Horticulturae 339:125−136

doi: 10.17660/ActaHortic.1993.339.11
[12]

Cox EF, McKee JMT, Dearman AS. 1976. The effect of growth rate on tipburn occurrence in lettuce. Journal of Horticultural Science 51:297−309

doi: 10.1080/00221589.1976.11514693
[13]

Goto E, Takakura T. 1992. Prevention of lettuce tipburn by supplying air to inner leaves. Transactions of the ASAE 35:641−645

doi: 10.13031/2013.28644
[14]

Koontz HV, Prince RP. 1986. Effect of 16 and 24 hours daily radiation (light) on lettuce growth. HortScience 21:123−124

doi: 10.21273/hortsci.21.1.123
[15]

Misaghi IJ, Grogan RG. 1978. Effect of temperature on tipburn development in head lettuce. Phytopathology 68:1738−1743

doi: 10.1094/phyto-68-1738
[16]

Tibbitts TW, Rao RR. 1968. Light intensity and duration in the development of lettuce tipburn. Proceedings of the American Society for Horticultural Science 93:454−461
[17]

Yanagi AA, Bullock RM, Cho JJ. 1983. Factors involved in the development of tipburn in crisphead lettuce in Hawaii. Journal of the American Society for Horticultural Science 108:234−237

doi: 10.21273/jashs.108.2.234
[18]

Collier GF, Huntington VC. 1983. The relationship between leaf growth, calcium accumulation and distribution, and tipburn development in field-grown butterhead lettuce. Scientia Horticulturae 21:123−128

doi: 10.1016/0304-4238(83)90157-7
[19]

Hayes RJ. 2017. Tipburn. In Compendium of Lettuce Diseases and Pests. 2nd Edition. Subbarao KV, Davis RM, Gibertson RL, Raid RN. St. Paul, Minnesota, USA: American Phytopathological Society. 165 pp. doi: 10.1094/9780890545782
[20]

Jenni S, Truco MJ, Michelmore RW. 2013. Quantitative trait loci associated with tipburn, heat stress-induced physiological disorders, and maturity traits in crisphead lettuce. Theoretical and Applied Genetics 126:3065−3079

doi: 10.1007/s00122-013-2193-7
[21]

Macias-González M, Truco MJ, Bertier LD, Jenni S, Simko I, et al. 2019. Genetic architecture of tipburn resistance in lettuce. Theoretical and Applied Genetics 132:2209−2222

doi: 10.1007/s00122-019-03349-6
[22]

Macias-González M, Truco MJ, Han R, Jenni S, Michelmore RW. 2021. High-resolution genetic dissection of the major QTL for tipburn resistance in lettuce, Lactuca sativa. G3 11:jkab097

doi: 10.1093/g3journal/jkab097
[23]

Beacham AM, Hand P, Teakle GR, Barker GC, Pink DAC, et al. 2023. Tipburn resilience in lettuce (Lactuca spp.) – the importance of germplasm resources and production system-specific assays. Journal of the Science of Food and Agriculture 103:4481−4488

doi: 10.1002/jsfa.12523
[24]

Seki K, Komatsu K, Tanaka K, Hiraga M, Kajiya-Kanegae H, et al. 2020. A CIN-like TCP transcription factor (LsTCP4) having retrotransposon insertion associates with a shift from Salinas type to Empire type in crisphead lettuce (Lactuca sativa L.). Horticulture Research 7:15

doi: 10.1038/s41438-020-0241-4
[25]

Simko I, Peng H, Sthapit Kandel J, Zhao R. 2022. Genome-wide association mapping reveals genomic regions frequently associated with lettuce field resistance to downy mildew. Theoretical and Applied Genetics 135:2009−2024

doi: 10.1007/s00122-022-04090-3
[26]

Sthapit Kandel J, Peng H, Hayes RJ, Mou B, Simko I. 2020. Genome-wide association mapping reveals loci for shelf life and developmental rate of lettuce. Theoretical and Applied Genetics 133:1947−1966

doi: 10.1007/s00122-020-03568-2
[27]

Simko I. 2024. Spatio-temporal dynamics of lettuce metabolome: a framework for targeted nutritional quality improvement. Plants 13:3316

doi: 10.3390/plants13233316
[28]

Federer WT. 2005. Augmented split block experiment design. Agronomy Journal 97:578−586

doi: 10.2134/agronj2005.0578
[29]

Rosental L, Still DW, You Y, Hayes RJ, Simko I. 2021. Mapping and identification of genetic loci affecting earliness of bolting and flowering in lettuce. Theoretical and Applied Genetics 134:3319−3337

doi: 10.1007/s00122-021-03898-9
[30]

Ott A, Liu S, Schnable JC, Yeh CTE, Wang KS, et al. 2017. tGBS® genotyping-by-sequencing enables reliable genotyping of heterozygous loci. Nucleic Acids Research 45:e178

doi: 10.1093/nar/gkx853
[31]

Simko I. 2023. Dataset on the single nucleotide variation in diversity panel of 500 lettuce accessions genotyped with tunable genotyping-by-sequencing (tGBS) method. Data in Brief 49:109419

doi: 10.1016/j.dib.2023.109419
[32]

Bradbury PJ, Zhang Z, Kroon DE, Casstevens TM, Ramdoss Y, et al. 2007. TASSEL: software for association mapping of complex traits in diverse samples. Bioinformatics 23:2633−2635

doi: 10.1093/bioinformatics/btm308
[33]

Simko I, Sthapit Kandel J, Peng H, Zhao R, Subbarao KV. 2023. Genetic determinants of lettuce resistance to drop caused by Sclerotinia minor identified through genome-wide association mapping frequently co-locate with loci regulating anthocyanin content. Theoretical and Applied Genetics 136:180

doi: 10.1007/s00122-023-04421-y
[34]

Reyes-Chin-Wo S, Wang Z, Yang X, Kozik A, Arikit S, et al. 2017. Genome assembly with in vitro proximity ligation data and whole-genome triplication in lettuce. Nature Communications 8:14953

doi: 10.1038/ncomms14953
[35]

White PJ, Broadley MR. 2003. Calcium in plants. Annals of Botany 92:487−511

doi: 10.1093/aob/mcg164
[36]

Saure MC. 1998. Causes of the tipburn disorder in leaves of vegetables. Scientia Horticulturae 76:131−147

doi: 10.1016/S0304-4238(98)00153-8
[37]

Simko I, Zhao R. 2023. Phenotypic characterization, plant growth and development, genome methylation, and mineral elements composition of neotetraploid lettuce (Lactuca sativa L.). Frontiers in Plant Science 14:1296660

doi: 10.3389/fpls.2023.1296660
[38]

Beacham AM, Wilkins KA, Davies JM, Monaghan JM. 2023. Vacuolar Ca2+/H+ exchanger and Ca2+ - ATPase homologues are differentially regulated in tipburn-resistant and susceptible lettuce (Lactuca sativa) cultivars. Plant Physiology and Biochemistry 201:107792

doi: 10.1016/j.plaphy.2023.107792
[39]

Barta DJ, Tibbitts TW. 1991. Calcium localization in lettuce leaves with and without tipburn: comparison of controlled-environment and field-grown plants. Journal of the American Society for Horticultural Science 116:870−875

doi: 10.21273/jashs.116.5.870
[40]

Bi Y, Zhang W, Yuan Y, Feng J, Wang P, et al. 2025. Transcriptome analysis revealed hub genes related to tipburn resistance in Chinese cabbage (Brassica rapa L. ssp. pekinensis). Plants 14:527

doi: 10.3390/plants14040527
[41]

Carassay LR, Bustos DA, Golberg AD, Taleisnik E. 2012. Tipburn in salt-affected lettuce (Lactuca sativa L.) plants results from local oxidative stress. Journal of Plant Physiology 169:285−293

doi: 10.1016/j.jplph.2011.10.004
[42]

Laxalt AM, van Hooren M, Munnik T. 2025. Plant PI-PLC signaling in stress and development. Plant Physiology 197:kiae534

doi: 10.1093/plphys/kiae534
[43]

Singh A, Bhatnagar N, Pandey A, Pandey GK. 2015. Plant phospholipase C family: regulation and functional role in lipid signaling. Cell Calcium 58:139−146

doi: 10.1016/j.ceca.2015.04.003
[44]

Wang HT, Bharadwaj VS, Yang JY, Curry TM, Moremen KW, et al. 2021. Rational enzyme design for controlled functionalization of acetylated xylan for cell-free polymer biosynthesis. Carbohydrate Polymers 273:118564

doi: 10.1016/j.carbpol.2021.118564
[45]

Zhong R, Zhou D, Chen L, Rose JP, Wang BC, et al. 2024. Plant cell wall polysaccharide O-acetyltransferases. Plants 13:2304

doi: 10.3390/plants13162304
[46]

He F, Shi YJ, Mi JX, Zhao KJ, Cui XL, et al. 2021. Genome-wide investigation of the NF-X1 gene family in Populus trichocarpa expression profiles during development and stress. International Journal of Molecular Sciences 22:4664

doi: 10.3390/ijms22094664
[47]

Haraguchi T, Ito K, Duan Z, Sa R, Takahashi K, et al. 2018. Functional diversity of class XI myosins in Arabidopsis thaliana. Plant and Cell Physiology 59:2268−2277

doi: 10.1093/pcp/pcy147
[48]

Pardo JM, Reddy MP, Yang S, Maggio A, Huh GH, et al. 1998. Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proceedings of the National Academy of Sciences 95:9681−9686

doi: 10.1073/pnas.95.16.9681
[49]

Li LH, Tian XR, Jiang Z, Zeng LW, He WF, et al. 2013. The Golgi apparatus: panel point of cytosolic Ca2+ regulation. Neurosignals 21:272−284

doi: 10.1159/000350471
[50]

Pizzo P, Lissandron V, Capitanio P, Pozzan T. 2011. Ca2+ signalling in the Golgi apparatus. Cell Calcium 50:184−192

doi: 10.1016/j.ceca.2011.01.006
[51]

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, et al. 2015. The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway. Science Signaling 8:ra101

doi: 10.1126/scisignal.aaa7677
[52]

Chebli Y, Bidhendi AJ, Kapoor K, Geitmann A. 2021. Cytoskeletal regulation of primary plant cell wall assembly. Current Biology 31:R681−R695

doi: 10.1016/j.cub.2021.03.092
[53]

Xiao C, Barnes WJ, Zamil MS, Yi H, Puri VM, et al. 2017. Activation tagging of Arabidopsis POLYGALACTURONASE INVOLVED IN EXPANSION 2 promotes hypocotyl elongation, leaf expansion, stem lignification, mechanical stiffening, and lodging. The Plant Journal 89:1159−1173

doi: 10.1111/tpj.13453
[54]

Fang S, Yang Y, Zhang X, Yang Z, Zhang M, et al. 2025. Structural mechanism underlying PHO1;H1-mediated phosphate transport in Arabidopsis. Nature Plants 11:309−320

doi: 10.1038/s41477-024-01895-6
[55]

Lemtiri-Chlieh F, MacRobbie EAC, Webb AAR, Manison NF, Brownlee C, et al. 2003. Inositol hexakisphosphate mobilizes an endomembrane store of calcium in guard cells. Proceedings of the National Academy of Sciences USA 100:10091−10095

doi: 10.1073/pnas.1133289100
[56]

Chen L, Zhu QH, Kaufmann K. 2020. Long non-coding RNAs in plants: emerging modulators of gene activity in development and stress responses. Planta 252:92

doi: 10.1007/s00425-020-03480-5
[57]

Wierzbicki AT, Blevins T, Swiezewski S. 2021. Long noncoding RNAs in plants. Annual Review of Plant Biology 72:245−271

doi: 10.1146/annurev-arplant-093020-035446
[58]

Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, et al. 2023. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nature Reviews Molecular Cell Biology 24:430−447

doi: 10.1038/s41580-022-00566-8
[59]

Lee J, Park I, Lee ZW, Kim SW, Baek N, et al. 2013. Regulation of the major vacuolar Ca2+ transporter genes, by intercellular Ca2+ concentration and abiotic stresses, in tip-burn resistant Brassica oleracea. Molecular Biology Reports 40:177−188

doi: 10.1007/s11033-012-2047-4
[60]

Kuronuma T, Watanabe H. 2021. Identification of the causative genes of calcium deficiency disorders in horticulture crops: a systematic review. Agriculture 11:906

doi: 10.3390/agriculture11100906