[1]

Saranya K, Manivasagan V, Gopi K, Karthik K. 2022. Broad-spectrum survey of medicinal plants as a potential source of anticancer agents. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas 21:1−40

doi: 10.37360/blacpma.22.21.1.01
[2]

Haque MU, Ferdiousi N, Sajon SR. 2016. Anticancer agents derived from plant and dietary sources: a review. International Journal of Pharmacognosy 3:55−66

doi: 10.13040/IJPSR.0975-8232.IJP.3(2).55-66
[3]

Dhyani P, Quispe C, Sharma E, Bahukhandi A, Sati P, et al. 2022. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell International 22:206

doi: 10.1186/s12935-022-02624-9
[4]

Sisodiya PS. 2013. Plant derived anticancer agents: a review. International Jornal of Research and Development in Pharmacy and Life Sciences 2:293−308
[5]

Rana A, Bajwa HK. 2023. Therapeutics of bioactive compounds from medicinal plants and honeybee products against cancer phytotherapy and apitherapy as alternatives to chemotherapy. Journal of Scientific & Industrial Research 82:805−817

doi: 10.56042/jsir.v82i08.1895
[6]

Newman DJ, Cragg GM. 2020. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. Journal of Natural Products 83(3):770−803

doi: 10.1021/acs.jnatprod.9b01285
[7]

Khan M, Maryam A, Mehmood T, Zhang Y, Ma T. 2015. Enhancing activity of anticancer drugs in multidrug resistant tumors by modulating P-glycoprotein through dietary nutraceuticals. Asian Pacific Journal of Cancer Prevention 16:6831−6839

doi: 10.7314/APJCP.2015.16.16.6831
[8]

Lunkes VL, Palma TV, Mostardeiro VB, Mastella MH, Assmann CE, et al. 2022. Curcumin and vinblastine induce apoptosis and impare migration in human cutaneous melanoma cells. Research, Society and Development 11:e20511225611

doi: 10.33448/rsd-v11i2.25611
[9]

Taub JW, Buck SA, Xavier AC, Edwards H, Matherly LH, et al. 2024. The evolution and history of Vinca alkaloids: from the Big Bang to the treatment of pediatric acute leukemia. Pediatric Blood & Cancer 71:e31247

doi: 10.1002/pbc.31247
[10]

Khan AW, Farooq M, Haseeb M, Choi S. 2022. Role of plant-derived active constituents in cancer treatment and their mechanisms of action. Cells 11:1326

doi: 10.3390/cells11081326
[11]

Zavala-Ortiz DA, Martínez-Montero MJ, Guedon E, Marc A, Ebel B, et al. 2021. Interest of cellular differentiation in the production of vincristine and vinblastine in suspension cultures of Catharanthus roseus (L.) G Don. Revista Mexicana de Ingeniería Química 20:807−821

doi: 10.24275/rmiq/bio2228
[12]

Buono R, Tucci J, Cutri R, Guidi N, Mangul S, et al. 2023. Fasting-mimicking diet inhibits autophagy and synergizes with chemotherapy to promote T-cell-dependent leukemia-free survival. Cancers 15:5870

doi: 10.3390/cancers15245870
[13]

Maqsood M, Abdul M. 2017. Yeast extract elicitation increases vinblastine and vincristine yield in protoplast derived tissues and plantlets in Catharanthus roseus. Revista Brasileira de Farmacognosia 27:549−556

doi: 10.1016/j.bjp.2017.05.008
[14]

Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, et al. 2022. A microbial supply chain for production of the anti-cancer drug vinblastine. Nature 609:341−347

doi: 10.1038/s41586-022-05157-3
[15]

Tonk D, Mujib A, Maqsood M, Khusrau M, Alsughayyir A, et al. 2023. Fungal elicitation enhances vincristine and vinblastine yield in the embryogenic tissues of Catharanthus roseus. Plants 12:3373

doi: 10.3390/plants12193373
[16]

Moudi M, Go R, Yien CY, Nazre M. 2013. Vinca alkaloids. International Journal of Preventive Medicine 4:1231−1235

doi: 10.1007/springerreference_37170
[17]

Muhammad N, Usmani D, Tarique M, Naz H, Ashraf M, et al. 2022. The role of natural products and their multitargeted approach to treat solid cancer. Cells 11:2209

doi: 10.3390/cells11142209
[18]

Elmore S. 2007. Apoptosis: a review of programmed cell death. Toxicologic Pathology 35:495−516

doi: 10.1080/01926230701320337
[19]

Hu S, Xu Y, Meng L, Huang L, Sun H. 2018. Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Experimental and Therapeutic Medicine 16:1266−1272

doi: 10.3892/etm.2018.6345
[20]

Neophytou CM, Trougakos IP, Erin N, Papageorgis P. 2021. Apoptosis deregulation and the development of cancer multi-drug resistance. Cancers 13:4363

doi: 10.3390/cancers13174363
[21]

Assaraf YG, Brozovic A, Gonçalves AC, Jurkovicova D, Linē A, et al. 2019. The multi-factorial nature of clinical multidrug resistance in cancer. Drug Resistance Updates 46:100645

doi: 10.1016/j.drup.2019.100645
[22]

Frei E, Whang J, Scoggins RB, Vanscott EJ, Rall DP, et al. 1964. The stathmokinetic effect of vincristime. Cancer Research 24:1918−1925
[23]

Niculescu AB III, Chen X, Smeets M, Hengst L, Prives C, et al. 1998. Effects of p21Cip1/Waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Molecular and Cellular Biology 18:629−643

doi: 10.1128/MCB.18.1.629
[24]

Lu X, Friedrich LJ, Efferth T. 2025. Natural products targeting tumour angiogenesis. British Journal of Pharmacology 182:2094−2136

doi: 10.1111/bph.16232
[25]

Li R, Song X, Guo Y, Song P, Duan D, et al. 2021. Natural products: a promising therapeutics for targeting tumor angiogenesis. Frontiers in Oncology 11:772915

doi: 10.3389/fonc.2021.772915
[26]

Bouyahya A, El Menyiy N, Oumeslakht L, El Allam A, Balahbib A, et al. 2021. Preclinical and clinical antioxidant effects of natural compounds against oxidative-stress-induced epigenetic instability in tumor cells. Antioxidants 10:1553

doi: 10.3390/antiox10101553
[27]

Kumar ASHUTOSH. 2016. Vincristine and vinblastine: a review. International Journal of Medicine and Pharmaceutical Science 6:23−30
[28]

Vipasha S, Hardeep K, Tarun K, Tullika M. 2016. Traditional Indian herb Catharanthus roseus used as cancer treatment: a review. International Journal of Pharmacognosy and Phytochemical Research 8:1926−1928
[29]

Tiwari D, Tiwari M. 2020. Vincristine: beyond on anticancer treatment. International Journal of Pharmacognosy and Life Science 1:38−43

doi: 10.33545/27072827.2020.v1.i2a.17
[30]

Saghatelyan T, Tananyan A, Janoyan N, Tadevosyan A, Petrosyan H, et al. 2020. Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced metastatic breast cancer: a comparative, randomized, double-blind, placebo-controlled clinical trial. Phytomedicine 70:153218

doi: 10.1016/j.phymed.2020.153218
[31]

Park MH, Choi MS, Kwak DH, Oh KW, Yoon DY, et al. 2011. Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB. The Prostate 71:801−812

doi: 10.1002/pros.21296
[32]

Albalawi AE, Althobaiti NA, Alrdahe SS, Alhasani RH, Alaryani FS, et al. 2021. Anti-tumor effects of queen bee acid (10-hydroxy-2-decenoic acid) alone and in combination with cyclophosphamide and its cellular mechanisms against Ehrlich solid tumor in mice. Molecules 26:7021

doi: 10.3390/molecules26227021
[33]

Haque MU, Alam AK, Islam-Shovon MT, Sujon KM, Hasan-Maruf MM, et al. 2024. Unveiling the apoptotic potential of antioxidant-rich Bangladeshi medicinal plant extractives and computational modeling to identify antitumor compounds. Heliyon a Cell Press Journal 10:e38885

doi: 10.2139/ssrn.4810862
[34]

Deep A, Kumar D, Bansal N, Narasimhan B, Marwaha RK, et al. 2023. Understanding mechanistic aspects and therapeutic potential of natural substances as anticancer agents. Phytomedicine Plus 3:100418

doi: 10.1016/j.phyplu.2023.100418
[35]

Javadi B. 2018. Diet therapy for cancer prevention and treatment based on traditional Persian medicine. Nutrition and Cancer 70:376−403

doi: 10.1080/01635581.2018.1446095
[36]

Dutta S. 2015. Natural sources as potential anticancer agents: a review. International Journal of Pharmaceutics and Drug Analysis 3:156−164
[37]

Wang H, Dong Z, Liu J, Zhu Z, Najafi M. 2023. Mechanisms of cancer-killing by quercetin; a review on cell death mechanisms. Anti-Cancer Agents in Medicinal Chemistry 23:999−1012

doi: 10.2174/1871520623666230120094158
[38]

Ahmed S, Othman NH. 2013. Honey as a potential natural anticancer agent: a review of its mechanisms. Evidence-Based Complementary and Alternative Medicine 2013:829070

doi: 10.1155/2013/829070
[39]

Kwon HK, Hwang JS, So JS, Lee CG, Sahoo A, et al. 2010. Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1. BMC Cancer 10:392

doi: 10.1186/1471-2407-10-392
[40]

Qi WJ, Sheng WS, Peng C, Ma X, Yao TZ. 2021. Investigating into anti-cancer potential of lycopene: molecular targets. Biomedicine & Pharmacotherapy 138:111546

doi: 10.1016/j.biopha.2021.111546
[41]

Díaz-Godínez G, Peña-Solis K, Díaz-Domínguez G. 2024. Algae as nutritional and bioactive food ingredients. Revista Mexicana de Ingeniería Química 23:Bio24209

doi: 10.24275/rmiq/bio24209
[42]

Gökkaya İ, Renda G, Ayhan F, Yazici N. 2025. Awareness of Apitherapy: a study of healthcare professionals in Türkiye. Journal of Pharmacopuncture 28:35−46

doi: 10.3831/KPI.2025.28.1.35
[43]

Hernandez-Peralta P, Garcia-Espejo DA, Gracia-Mora MI, Velasco-Velasquez MA, Cobos-Marin L. 2023. Agave mapisaga aqueous extract shows in vitro and in vivo activity on murine prostate cancer cells. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas 22:37−47

doi: 10.37360/blacpma.23.22.1.3
[44]

Necip A, Demirtas I, Tayhan SE, Işık M, Bilgin S, et al. 2024. Isolation of phenolic compounds from eco-friendly white bee propolis: antioxidant wound-healing, and anti-Alzheimer effects. Food Science and Nutrition 12:1928−1939

doi: 10.1002/fsn3.3888
[45]

Bose D, Famurewa AC, Akash A, Othman EM. 2024. The therapeutic mechanisms of honey in mitigating toxicity from anticancer chemotherapy: a review. Journal of Xenobiotics 14:1109−1129

doi: 10.3390/jox14030063
[46]

Ferguson PJ, Phillips JR, Selner M, Cass CE. 1984. Differential activity of vincristine and vinblastine against cultured cells. Cancer Research 44:3307−3312
[47]

De Witt M, Gamble A, Hanson D, Markowitz D, Powell C, et al. 2017. Repurposing mebendazole as a replacement for vincristine for the treatment of brain tumors. Molecular Medicine 23:50−56

doi: 10.3410/f.727494772.793538638
[48]

Mayer S, Keglevich A, Sepsey-Für C, Bölcskei H, Ilkei V, et al. 2020. Results in chemistry of natural organic compounds. Synthesis of new anticancer Vinca alkaloids and flavone alkaloids. Chemistry 2:714−726

doi: 10.3390/chemistry2030046
[49]

Rammali S, Idir A, Aherkou M, Ciobică A, Kamal FZ, et al. 2024. In vitro and computational investigation of antioxidant and anticancer properties of Streptomyces coeruleofuscus SCJ extract on MDA-MB-468 triple-negative breast cancer cells. Scientific Reports 14:25251

doi: 10.1038/s41598-024-76200-8
[50]

Milacic V, Banerjee S, Landis-Piwowar KR, Sarkar FH, Majumdar APN, et al. 2008. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Research 68:7283−7292

doi: 10.1158/0008-5472.CAN-07-6246
[51]

Sameni HR, Yosefi S, Alipour M, Pakdel A, Torabizadeh N, et al. 2021. Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice. Life Sciences 276:119390

doi: 10.1016/j.lfs.2021.119390
[52]

Inoue K, Saito M, Kanai T, Kawata T, Shigematsu N, et al. 2008. Anti-tumor effects of water-soluble propolis on a mouse sarcoma cell line in vivo and in vitro. The American Journal of Chinese Medicine 36:625−634

doi: 10.1142/S0192415X0800603X
[53]

Salehi A, Hosseini SM, Kazemi S. 2022. Antioxidant and anticarcinogenic potentials of propolis for dimethylhydrazine-induced colorectal cancer in Wistar rats. BioMed Research International 2022:8497562

doi: 10.1155/2022/8497562
[54]

Meijerman I, Beijnen JH, Schellens JHM. 2006. Herb-drug interactions in oncology: focus on mechanisms of induction. The Oncologist 11:742−752

doi: 10.1634/theoncologist.11-7-742
[55]

Ramezani A, Haddad R, Sedaghati B, Jafari D, Jafari N. 2018. Effects of fungal extracts on vinblastine and vincristine production and their biosynthesis pathway genes in Catharanthus roseus. South African Journal of Botany 119:163−171

doi: 10.1016/j.sajb.2018.08.015
[56]

Lin K, Lu LX, Pan BZ, Chai X, Fu QT, et al. 2025. Agrobacterium rhizogenes-mediated hairy root genetic transformation using Agrobacterium gel inoculation and RUBY reporter enables efficient gene function analysis in Sacha inchi (Plukenetia volubilis). International Journal of Molecular Sciences 26:2496

doi: 10.3390/ijms26062496
[57]

Vu PTB, Cao DM, Bui AL, Nguyen NN, Van Bui L, et al. 2022. In vitro growth and content of vincristine and vinblastine of Catharanthus roseus L. hairy roots in response to precursors and elicitors. Plant Science Today 9:21−28

doi: 10.14719/pst.1337
[58]

Rai V, Tandon PK, Khatoon S. 2014. Effect of chromium on antioxidant potential of Catharanthus roseus varieties and production of their anticancer alkaloids: vincristine and vinblastine. BioMed Research International 2014:934182

doi: 10.1155/2014/934182
[59]

Sahi N, Mostajeran A, Ghanadian M. 2022. Changing in the production of anticancer drugs (vinblastine and vincristine) in Catharanthus roseus (L.) G. Don by potassium and ascorbic acid treatments. Plant, Soil and Environment 68:18−28

doi: 10.17221/121/2021-pse
[60]

Zhang Y, Hu C. 2020. Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids. Archiv der Pharmazie 353:e2000092

doi: 10.1002/ardp.202000092
[61]

Khan U, Gond SK. 2024. Detection of vinblastine and related bioactive compounds from culture extracts of endophytic fungi of Catharanthus roseus. World Journal of Microbiology and Biotechnology 40:278

doi: 10.1007/s11274-024-04078-9
[62]

Keglevich P, Hazai L, Kalaus G, Szántay C. 2012. Modifications on the basic skeletons of vinblastine and vincristine. Molecules 17:5893−5914

doi: 10.3390/molecules17055893
[63]

Hua Y, Dai X, Xu Y, Xing G, Liu H, et al. 2022. Drug repositioning: Progress and challenges in drug discovery for various diseases. European Journal of Medicinal Chemistry 234:114239

doi: 10.1016/j.ejmech.2022.114239
[64]

Bai RY, Staedtke V, Aprhys CM, Gallia GL, Riggins GJ. 2011. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro-oncology 13:974−982

doi: 10.1093/neuonc/nor077