[1]

Ding MJ, Fang HR, Zhang JK, Shi JH, Yu X, et al. 2022. E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination. Hepatology 76:94−111

doi: 10.1002/hep.32226
[2]

Wang Y, Yang Y, Wang M, Wang S, Jeong JM, et al. 2021. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Science Translational Medicine 13:abb6576

doi: 10.1126/scitranslmed.abb6576
[3]

Li R, Xie L, Li L, Chen X, Yao T, et al. 2022. The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice. Pharmaceutica Sinica B 12:182−196

doi: 10.1016/j.apsb.2021.05.029
[4]

Jia K, Zhang Y, Luo R, Liu R, Li Y, et al. 2023. Acteoside ameliorates hepatic ischemia-reperfusion injury via reversing the senescent fate of liver sinusoidal endothelial cells and restoring compromised sinusoidal networks. International Journal of Biological Sciences 19:4967−4988

doi: 10.7150/ijbs.87332
[5]

Liu J, Luo R, Zhang Y, Li X. 2024. Current status and perspective on molecular targets and therapeutic intervention strategy in hepatic ischemia-reperfusion injury. Clinical and Molecular Hepatology 30:585−619

doi: 10.3350/cmh.2024.0222
[6]

Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang X, et al. 2018. An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nature Medicine 24:73−83

doi: 10.1038/nm.4451
[7]

Abulikemu A, Zhao X, Xu H, Li Y, Ma R, et al. 2023. Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress. Redox Biology 59:102569

doi: 10.1016/j.redox.2022.102569
[8]

Resseguie EA, Staversky RJ, Brookes PS, O'Reilly MA. 2015. Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction. Redox Biology 5:176−185

doi: 10.1016/j.redox.2015.04.012
[9]

Ma XM, Geng K, Law BY, Wang P, Pu YL, et al. 2023. Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes. Cell Biology and Toxicology 39:277−299

doi: 10.1007/s10565-021-09692-z
[10]

Zhang Q, Wei J, Liu Z, Huang X, Sun M, et al. 2022. STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice. Redox Biology 54:102367

doi: 10.1016/j.redox.2022.102367
[11]

Ward GA, McGraw KL, Abbas-Aghababazadeh F, Meyer BS, McLemore AF, et al. 2021. Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes. Blood Advances 5:2216−2228

doi: 10.1182/bloodadvances.2020003475
[12]

Wu W, Bao W, Chen X, Lu Y, Fang J, et al. 2023. Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways. Redox Biology 64:102775

doi: 10.1016/j.redox.2023.102775
[13]

Lai JH, Wu DW, Wu CH, Hung LF, Huang CY, et al. 2021. Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. iScience 24:102498

doi: 10.1016/j.isci.2021.102498
[14]

Zhu S, Liao L, Zhong Y, Liu Z, Lu J, et al. 2025. Hepatocellular CMPK2 promotes the development of metabolic dysfunction-associated steatohepatitis. Journal of Hepatology 83:383−396

doi: 10.1016/j.jhep.2025.01.008
[15]

Elsayed Abouzed DE, Ezelarab HAA, Selim HMRM, Elsayed MMA, El Hamd MA, Aboelez MO. 2024. Multimodal modulation of hepatic ischemia/reperfusion-induced injury by phytochemical agents: a mechanistic evaluation of hepatoprotective potential and safety profiles. International Immunopharmacology 138:112445

doi: 10.1016/j.intimp.2024.112445
[16]

Ma W, Tang S, Xie D, Gu G, Gan L. 2021. The protective effect of traditional Chinese medicine on liver ischemia-reperfusion injury. Evidence-Based Complementary and Alternative Medicine 2021:5564401

doi: 10.1155/2021/5564401
[17]

Jia K, Zhang Y, Li F, Liu R, Wu J, et al. 2025. Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2. Pharmaceutica Sinica B 15:2077−2094

doi: 10.1016/j.apsb.2025.03.002
[18]

Xu X, Pang Y, Fan X. 2025. Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances. Signal Transduction and Targeted Therapy 10:190

doi: 10.1038/s41392-025-02253-4
[19]

Ma Z, Xie K, Xue X, Li J, Yang Y, et al. 2024. Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA. Journal of Ethnopharmacology 328:118057

doi: 10.1016/j.jep.2024.118057
[20]

Chen J, Wang T, Li X, Gao L, Wang K, et al. 2024. DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease. Signal Transduction and Targeted Therapy 9:163

doi: 10.1038/s41392-024-01881-6
[21]

Filiberto AC, Spinosa MD, Elder CT, Su G, Leroy V, et al. 2022. Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation. Nature Communications 13:1521

doi: 10.1038/s41467-022-29233-4
[22]

Gong T, Liu L, Jiang W, Zhou R. 2020. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nature Reviews Immunology 20:95−112

doi: 10.1038/s41577-019-0215-7
[23]

Lee WS, Kim DS, Kim JH, Heo Y, Yang H, et al. 2022. Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade. Journal for Immunotherapy of Cancer 10:e004799

doi: 10.1136/jitc-2022-004799
[24]

Tan S, Wang Z, Li N, Guo X, Zhang Y, et al. 2023. Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response. Cell Death & Differentiation 30:2104−2119

doi: 10.1038/s41418-023-01202-4
[25]

Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, et al. 2018. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198−203

doi: 10.1038/s41586-018-0372-z
[26]

Mizushima N, Komatsu M. 2011. Autophagy: renovation of cells and tissues. Cell 147:728−741

doi: 10.1016/j.cell.2011.10.026
[27]

Liu K, Qiu D, Liang X, Huang Y, Wang Y, et al. 2022. Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy. Autophagy 18:860−876

doi: 10.1080/15548627.2021.1961072
[28]

Xue T, Liu P, Zhou Y, Liu K, Yang L, et al. 2016. Interleukin-6 induced "acute" phenotypic microenvironment promotes Th1 anti-tumor immunity in cryo-thermal therapy revealed by shotgun and parallel reaction monitoring proteomics. Theranostics 6:773−794

doi: 10.7150/thno.14394
[29]

Brenner C, Galluzzi L, Kepp O, Kroemer G. 2013. Decoding cell death signals in liver inflammation. Journal of Hepatology 59:583−594

doi: 10.1016/j.jhep.2013.03.033
[30]

Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, et al. 2019. Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity. Nature Metabolism 1:86−97

doi: 10.1038/s42255-018-0003-x
[31]

Kuwabara WMT, Rui C, Alba-Loureiro TC. 2017. Autophagy is impaired in neutrophils from streptozotocin-induced diabetic rats. Frontiers in Immunology 8:24

doi: 10.3389/fimmu.2017.00024
[32]

Moon JS, da Cunha FF, Huh JY, Andreyev AY, Lee J, et al. 2021. ANT2 drives proinflammatory macrophage activation in obesity. JCI Insight 6:e147033

doi: 10.1172/jci.insight.147033
[33]

Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, et al. 2022. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity 55:1370−1385.e8

doi: 10.1016/j.immuni.2022.06.007
[34]

Zheng Y, Xie Y, Li J, Cao Y, Li M, et al. 2025. CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis. Clinical and Translational Medicine 15:e70180

doi: 10.1002/ctm2.70180
[35]

Tao M, Wang L, Chen C, Tang M, Wang Y, et al. 2026. Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition. Journal of Advanced Research 80:593−608

doi: 10.1016/j.jare.2025.04.030
[36]

Jing L, Zhang X, Liu D, Yang Y, Xiong H, et al. 2022. ACK1 contributes to the pathogenesis of inflammation and autoimmunity by promoting the activation of TLR signaling pathways. Frontiers in Immunology 13:864995

doi: 10.3389/fimmu.2022.864995
[37]

Xiao S, Yu Y, Liao M, Song D, Xu X, et al. 2025. Post-translational modification of p62: roles and regulations in autophagy. Cells 14:1016

doi: 10.3390/cells14131016