| [1] |
Walsh G, Walsh E. 2022. Biopharmaceutical benchmarks 2022. |
| [2] |
Sergeeva D, Lee GM, Nielsen LK, Grav LM. 2020. Multicopy targeted integration for accelerated development of high-producing Chinese hamster ovary cells. |
| [3] |
Feary M, Moffat MA, Casperson GF, Allen MJ, Young RJ. 2021. CHOK1SV GS-KO SSI expression system: a combination of the Fer1L4 locus and glutamine synthetase selection. |
| [4] |
Hagedorn C, Schnödt-Fuchs M, Boehme P, Abdelrazik H, Lipps HJ, et al. 2017. S/MAR element facilitates episomal long-term persistence of adeno-associated virus vector genomes in proliferating cells. |
| [5] |
Sizer RE, White RJ. 2023. Use of ubiquitous chromatin opening elements (UCOE) as tools to maintain transgene expression in biotechnology. |
| [6] |
Grav LM, Sergeeva D, Lee JS, Marin de Mas I, Lewis NE, et al. 2018. Minimizing clonal variation during mammalian cell line engineering for improved systems biology data generation. |
| [7] |
Hamaker NK, Lee KH. 2018. Site-specific integration ushers in a new era of precise CHO cell line engineering. |
| [8] |
Turan S, Zehe C, Kuehle J, Qiao J, Bode J. 2013. Recombinase-mediated cassette exchange (RMCE) − a rapidly-expanding toolbox for targeted genomic modifications. |
| [9] |
Carver J, Ng D, Zhou M, Ko P, Zhan D, et al. 2020. Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position. |
| [10] |
Pristovšek N, Nallapareddy S, Grav LM, Hefzi H, Lewis NE, et al. 2019. Systematic evaluation of site-specific recombinant gene expression for programmable mammalian cell engineering. |
| [11] |
Johari YB, Brown AJ, Alves CS, Zhou Y, Wright CM, et al. 2019. CHO genome mining for synthetic promoter design. |
| [12] |
Brown AJ, Gibson SJ, Hatton D, James DC. 2017. In silico design of context-responsive mammalian promoters with user-defined functionality. |
| [13] |
Sou SN, Harris CL, Williams R, Kozub D, Zurlo F, et al. 2023. CHO synthetic promoters improve expression and product quality of biotherapeutic proteins. |
| [14] |
Blanco N, Williams AJ, Tang D, Zhan D, Misaghi S, et al. 2020. Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product-related impurities in CHO cells. |
| [15] |
Gay R, Kallmeier R, Norman A, Kalwy S. 2008. Mammalian expression vector comprising the mCMV promoter and first intron of hCMV major immediate early gene. European Patent No. EP-1874929-A2. https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20080109&DB=&locale=en_EP&CC=EP&NR=1874929A2&KC=A2&ND=1 |
| [16] |
Jin L, Nawab S, Xia M, Ma X, Huo YX. 2019. Context-dependency of synthetic minimal promoters in driving gene expression: a case study. |
| [17] |
Smith RP, Taher L, Patwardhan RP, Kim MJ, Inoue F, et al. 2013. Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model. |
| [18] |
Kim M, O'Callaghan PM, Droms KA, James DC. 2011. A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies. |
| [19] |
Yang Y, Mariati, Chusainow J, Yap MGS. 2010. DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines. |
| [20] |
Bevilacqua A, Ceriani MC, Capaccioli S, Nicolin A. 2003. Post-transcriptional regulation of gene expression by degradation of messenger RNAs. |
| [21] |
Schaefke B, Sun W, Li YS, Fang L, Chen W. 2018. The evolution of posttranscriptional regulation. |
| [22] |
Corbett AH. 2018. Post-transcriptional regulation of gene expression and human disease. |
| [23] |
Shi J, Wang Q, Li T, Jin X, Ying H, et al. 2023. Antigen-binding molecules that specifically bind EGFR and CD28 and their medicinal uses. PCT Patent No. WO 2023/198042-A1. https://patentscope2.wipo.int/search/zh/detail.jsf?docId=WO2023198042&_gid=202342 |
| [24] |
Klein JC, Agarwal V, Inoue F, Keith A, Martin B, et al. 2020. A systematic evaluation of the design and context dependencies of massively parallel reporter assays. |
| [25] |
Arnold CD, Gerlach D, Stelzer C, Boryń ŁM, Rath M, et al. 2013. Genome-wide quantitative enhancer activity maps identified by STARR-seq. |
| [26] |
Jores T, Tonnies J, Wrightsman T, Buckler ES, Cuperus JT, et al. 2021. Synthetic promoter designs enabled by a comprehensive analysis of plant core promoters. |
| [27] |
Kotopka BJ, Smolke CD. 2020. Model-driven generation of artificial yeast promoters. |
| [28] |
Thaisuchat H, Baumann M, Pontiller J, Hesse F, Ernst W. 2011. Identification of a novel temperature sensitive promoter in CHO cells. |
| [29] |
Fomina-Yadlin D, Mujacic M, Maggiora K, Quesnell G, Saleem R, et al. 2015. Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression. |
| [30] |
Sha S, Bhatia H, Yoon S. 2018. An RNA-seq based transcriptomic investigation into the productivity and growth variants with Chinese hamster ovary cells. |
| [31] |
Curtin JA, Dane AP, Swanson A, Alexander IE, Ginn SL. 2008. Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. |
| [32] |
Wellen KE, Thompson CB. 2010. Cellular metabolic stress: considering how cells respond to nutrient excess. |
| [33] |
Brown AJ, Sweeney B, Mainwaring DO, James DC. 2015. NF-κB, CRE and YY1 elements are key functional regulators of CMV promoter-driven transient gene expression in CHO cells. |
| [34] |
Patel YD, Brown AJ, Zhu J, Rosignoli G, Gibson SJ, et al. 2021. Control of multigene expression stoichiometry in mammalian cells using synthetic promoters. |
| [35] |
Dong E, Lam C, Tang D, Louie S, Yim M, et al. 2021. Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost-effective method for expression of complex molecules. |
| [36] |
Lee JS, Kallehauge TB, Pedersen LE, Kildegaard HF. 2015. Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway. |