[1]

Li F, Deng X, Huang Z, Zhao Z, Li C, et al. 2023. Integrated transcriptome and metabolome provide insights into flavonoid biosynthesis in 'P113', a new purple tea of Camellia tachangensis. Beverage Plant Research 3:3

doi: 10.48130/BPR-2023-0003
[2]

Niu S, Song Q, Koiwa H, Qiao D, Zhao D, et al. 2019. Genetic diversity, linkage disequilibrium, and population structure analysis of the tea plant (Camellia sinensis) from an origin center, Guizhou plateau, using genome-wide SNPs developed by genotyping-by-sequencing. BMC Plant Biology 19(1):328

doi: 10.1186/s12870-019-1917-5
[3]

Wang Y, Niu S, Deng X, Bai D, Chen Z, et al. 2024. Genome-wide association study, population structure, and genetic diversity of the tea plant in Guizhou Plateau. BMC Plant Biology 24(1):79

doi: 10.1186/s12870-024-04761-x
[4]

Bedrood Z, Rameshrad M, Hosseinzadeh H. 2018. Toxicological effects of Camellia sinensis (green tea): a review. Phytotherapy Research 32(7):1163−1180

doi: 10.1002/ptr.6063
[5]

Xiong B, Yang Y, Li Q, Niu S. 2025. Evolutionary dynamics and functional characterization of jasmonate ZIM-domain (JAZ) genes across Camellia sinensis pan-genome. Beverage Plant Research 5:e036

doi: 10.48130/bpr-0025-0027
[6]

Mahmood T, Akhtar N, Khan BA. 2010. The morphology, characteristics, and medicinal properties of Camellia sinensis tea. Journal of Medicinal Plants Research 4(19):2028−2033

doi: 10.5897/JMPR10.010
[7]

Hibi M, Takase H, Iwasaki M, Osaki N, Katsuragi Y. 2018. Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: a pooled analysis of 6 human trials. Nutrition Research 55:1−10

doi: 10.1016/j.nutres.2018.03.012
[8]

Liu Y, Li S, Xu X, Ma J, Li X, et al. 2025. Harnessing functional metabolite diversity in tea plant germplasm: from metabolic signatures to quality-oriented breeding. Beverage Plant Research 5:e034

doi: 10.48130/bpr-0025-0025
[9]

Sandoval V, Sanz-Lamora H, Arias G, Marrero PF, Haro D, Relat J, et al. 2020. Metabolic impact of flavonoids consumption in obesity: from central to peripheral. Nutrients 12(8):2393

doi: 10.3390/nu12082393
[10]

Xu YQ, Zhang YN, Chen JX, Wang F, Du QZ, et al. 2018. Quantitative analyses of the bitterness and astringency of catechins from green tea. Food Chemistry 258:16−24

doi: 10.1016/j.foodchem.2018.03.042
[11]

Gupta PK, Kulwal PL, Jaiswal V. 2019. Association mapping in plants in the post-GWAS genomics era. Advances in Genetics 104:75−154

doi: 10.1016/bs.adgen.2018.12.001
[12]

Uffelmann E, Huang QQ, Munung NS, de Vries J, Okada Y, et al. 2021. Genome-wide association studies. Nature Reviews Methods Primers 1:59

doi: 10.1038/s43586-021-00056-9
[13]

Atwell S, Huang YS, Vilhjálmsson BJ, Willems G, Horton M, et al. 2010. Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature 465:627−631

doi: 10.1038/nature08800
[14]

Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, et al. 2017. 10 years of GWAS discovery: biology, function, and translation. American Journal of Human Genetics 101(1):5−22

doi: 10.1016/j.ajhg.2017.06.005
[15]

Li J, Chang X, Huang Q, Liu P, Zhao X, et al. 2023. Construction of SNP fingerprint and population genetic analysis of honeysuckle germplasm resources in China. Frontiers in Plant Science 14:1080691

doi: 10.3389/fpls.2023.1080691
[16]

Fang K, Xia Z, Li H, Jiang X, Qin D, et al. 2021. Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites. Horticulture Research 8:42

doi: 10.1038/s41438-021-00477-3
[17]

Deng X, Huang D, Wang Y, An H, Bai D, et al. 2025. Genome-wide association study of salicylic acid provides genetic insights for tea plant selective breeding. Horticulture Research 12(4):uhae362

doi: 10.1093/hr/uhae362
[18]

Liu M, Tian HL, Wu JH, Cang RR, Wang RX, et al. 2015. Relationship between gene expression and the accumulation of catechin during spring and autumn in tea plants (Camellia sinensis L.). Horticulture Research 2:15011

doi: 10.1038/hortres.2015.11
[19]

Xiang P, Marat T, Huang J, Cheng B, Liu J, et al. 2025. Response of photosynthetic capacity to ecological factors and its relationship with EGCG biosynthesis of tea plant (Camellia sinensis). BMC Plant Biology 25(1):199

doi: 10.1186/s12870-025-06106-8
[20]

OuYang Y, Rao K, He L, Song Q, Wang X, et al. 2025. Identification of CsRNF144 as a key gene regulating di-hydroxy catechins accumulation in Camellia tachangensis through genome-wide association studies. Horticultural Plant Journal In press

doi: 10.1016/j.hpj.2025.01.004
[21]

Xia E, Tong W, Hou Y, An Y, Chen L, et al. 2020. The reference genome of tea plant and resequencing of 81 diverse accessions provide insights into its genome evolution and adaptation. Molecular Plant 13(7):1013−1026

doi: 10.1016/j.molp.2020.04.010
[22]

Bradbury PJ, Zhang Z, Kroon DE, Casstevens TM, Ramdoss Y, et al. 2007. TASSEL: software for association mapping of complex traits in diverse samples. Bioinformatics 23(19):2633−2635

doi: 10.1093/bioinformatics/btm308
[23]

Liu CC, Shringarpure S, Lange K, Novembre J. 2020. Exploring population structure with admixture models and principal component analysis. Statistical Population Genomics 2090:67−86

doi: 10.1007/978-1-0716-0199-0_4
[24]

Stecher G, Tamura K, Kumar S. 2020. Molecular evolutionary genetics analysis (MEGA) for macOS. Molecular Biology and Evolution 37(4):1237−1239

doi: 10.1093/molbev/msz312
[25]

Danecek P, Auton A, Abecasis G, Albers CA, Banks E, et al. 2011. The variant call format and VCFtools. Bioinformatics 27(15):2156−2158

doi: 10.1093/bioinformatics/btr330
[26]

Zhang F, Tian W, Cen L, Lv L, Zeng X, et al. 2022. Population structure analysis and genome-wide association study of tea (Camellia sinensis (L.) kuntze) germplasm in Qiannan, China, based on SLAFseq technology. Phyton-International Journal of Experimental Botany 91(4):791−809

doi: 10.32604/phyton.2022.018104
[27]

Wang RJ, Gao XF, Yang J, Kong XR. 2019. Genome-wide association study to identify favorable SNP allelic variations and candidate genes that control the timing of spring bud flush of tea (Camellia sinensis) using SLAF-seq. Journal of Agricultural and Food Chemistry 67:10380-10391

doi: 10.1021/acs.jafc.9b03330
[28]

Rao K, Ouyang Y, Chen Y, Wang X, Liu T, et al. 2026. Identification of CsAK as a critical caffeine-related upstream gene in tea accessions through genome-wide association study. Journal of Integrative Agriculture 25(4):1519–1530

doi: 10.1016/j.jia.2025.06.026
[29]

Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCᴛ method. Methods 25(4):402−408

doi: 10.1006/meth.2001.1262
[30]

Sang S, Lambert JD, Ho CT, Yang CS. 2011. The chemistry and biotransformation of tea constituents. Pharmacological Research 64:87–99

doi: 10.1016/j.phrs.2011.02.007
[31]

Musial C, Kuban-Jankowska A, Gorska-Ponikowska M. 2020. Beneficial properties of green tea catechins. International Journal of Molecular Sciences 21(5):1744

doi: 10.3390/ijms21051744
[32]

Balentine DA, Wiseman SA, Bouwens LCM. 1997. The chemistry of tea flavonoids. Critical Reviews in Food Science and Nutrition 37(8):693−704

doi: 10.1080/10408399709527797
[33]

Chen Y, Niu S, Deng X, Song Q, He L, et al. 2023. Genome-wide association study of leaf-related traits in tea plant in Guizhou based on genotyping-by-sequencing. BMC Plant Biology 23(1):196

doi: 10.1186/s12870-023-04192-0
[34]

Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics 38(8):904−909

doi: 10.1038/ng1847
[35]

Cebeci Z, Bayraktar M, Gökçe G. 2023. Comparison of the statistical methods for genome-wide association studies on simulated quantitative traits of domesticated goats (Capra hircus L.). Small Ruminant Research 227:107053

doi: 10.1016/j.smallrumres.2023.107053
[36]

Kaler AS, Gillman JD, Beissinger T, Purcell LC. 2020. Comparing different statistical models and multiple testing corrections for association mapping in soybean and maize. Frontiers in Plant Science 10:1794

doi: 10.3389/fpls.2019.01794
[37]

Nordborg M, Hu TT, Ishino Y, Jhaveri J, Toomajian C, et al. 2005. The pattern of polymorphism in Arabidopsis thaliana. PLoS Biology 3(7):e196

doi: 10.1371/journal.pbio.0030196
[38]

Zhang W, Zhang Y, Qiu H, Guo Y, Wan H, et al. 2020. Genome assembly of wild tea tree DASZ reveals pedigree and selection history of tea varieties. Nature Communications 11:3719

doi: 10.1038/s41467-020-17498-6
[39]

Konwar T, Sarma RN, Sarmah BK. 2025. Genome wide association analysis of flavour related metabolites in tea germplasm [Camellia sinensis (L.) Kuntze] from Assam using a genotyping by sequencing strategy. BMC Plant Biology 25(1):911

doi: 10.1186/s12870-025-06889-w
[40]

Kong W, Kong X, Xia Z, Li X, Wang F, et al. 2025. Genomic analysis of 1,325 Camellia accessions sheds light on agronomic and metabolic traits for tea plant improvement. Nature Genetics 57:997−1007

doi: 10.1038/s41588-025-02135-z
[41]

Wang X, Li X, Chen D, Gao J, Hao S, et al. 2026. Core germplasm construction of tea plant populations based on genome-wide SNP and catechins in Shaanxi Province, China. Journal of Integrative Agriculture 25(5):1927−1938

doi: 10.1016/j.jia.2025.03.024
[42]

Wang L, Wang Y, Wang Y, Wu L, He M, et al. 2025. Two shikimate dehydrogenases play an essential role in the biosynthesis of galloylated catechins in tea plants. Horticulture Research 12(4):uhae356

doi: 10.1093/hr/uhae356
[43]

Li P, Fu J, Xu Y, Shen Y, Zhang Y, et al. 2022. CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication. New Phytologist 234(3):902−917

doi: 10.1111/nph.18026
[44]

Wang YS, Xu YJ, Gao LP, Yu O, Wang XZ, et al. 2014. Functional analysis of flavonoid 3′,5′-hydroxylase from tea plant (Camellia sinensis): critical role in the accumulation of catechins. BMC Plant Biology 14:347

doi: 10.1186/s12870-014-0347-7
[45]

Hiromoto T, Honjo E, Noda N, Tamada T, Kazuma K, et al. 2015. Structural basis for acceptor-substrate recognition of UDP-glucose: anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea. Protein Science 24(3):395−407

doi: 10.1002/pro.2630
[46]

Wei L, Wang W, Li T, Chen O, Yao S, et al. 2023. Genome-wide identification of the CsPAL gene family and functional analysis for strengthening green mold resistance in Citrus fruit. Postharvest Biology and Technology 196:112178

doi: 10.1016/j.postharvbio.2022.112178
[47]

Sun L, Wang Y, Ding Z, Liu F. 2019. The dynamic changes of catechins and related genes in tea (Camellia sinensis) flowers. Acta Physiologiae Plantarum 41:30

doi: 10.1007/s11738-019-2822-0
[48]

Zhu C, Zhang S, Fu H, Zhou C, Chen L, et al. 2019. Transcriptome and phytochemical analyses provide new insights into long non-coding RNAs modulating characteristic secondary metabolites of oolong tea (Camellia sinensis) in solar-withering. Frontiers in Plant Science 10:1638

doi: 10.3389/fpls.2019.01638
[49]

Pan H, Zhou R, Louie GV, Mühlemann JK, Bomati EK, et al. 2014. Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis. The Plant Cell 26(9):3709−3727

doi: 10.1105/tpc.114.127399
[50]

Sun F, Dong X, Li S, Sha H, Gao W, et al. 2023. Genome-wide identification and expression analysis of SUT gene family members in sugar beet (Beta vulgaris L.). Gene 870:147422

doi: 10.1016/j.gene.2023.147422
[51]

Li ZX, Yang WJ, Ahammed GJ, Shen C, Yan P, et al. 2016. Developmental changes in carbon and nitrogen metabolism affect tea quality in different leaf position. Plant Physiology and Biochemistry 106:327−335

doi: 10.1016/j.plaphy.2016.06.027
[52]

Li J, Wang Y, Suh JH. 2022. Multi-omics approach in tea polyphenol research regarding tea plant growth, development and tea processing: current technologies and perspectives. Food Science and Human Wellness 11(3):524−536

doi: 10.1016/j.fshw.2021.12.010
[53]

Gong X, Liu M, Zhang L, Ruan Y, Ding R, et al. 2015. Arabidopsis AtSUC2 and AtSUC4, encoding sucrose transporters, are required for abiotic stress tolerance in an ABA-dependent pathway. Physiologia Plantarum 153(1):119−136

doi: 10.1111/ppl.12225
[54]

Zhang X, Gou M, Liu CJ. 2013. Arabidopsis kelch repeat F-box proteins regulate phenylpropanoid biosynthesis via controlling the turnover of phenylalanine ammonia-lyase. The Plant Cell 25(12):4994−5010

doi: 10.1105/tpc.113.119644
[55]

Ni X, Wang Y, Dai L, Jiang K, Zeng S, et al. 2025. The transcription factor GmbZIP131 enhances soybean salt tolerance by regulating flavonoid biosynthesis. Plant Physiology 197(3):kiaf092

doi: 10.1093/plphys/kiaf092
[56]

Sana, Aftab T, Naeem M, Jha PK, Vara Prasad PVV. 2025. Production of secondary metabolites under challenging environments: understanding functions and mechanisms of signalling molecules. Frontiers in Plant Science 16:1569014

doi: 10.3389/fpls.2025.1569014
[57]

Liu Y, Gao L, Liu L, Yang Q, Lu Z, et al. 2012. Purification and characterization of a novel galloyltransferase involved in catechin galloylation in the tea plant (Camellia sinensis). Journal of Biological Chemistry 287(53):44406−44417

doi: 10.1074/jbc.M112.403071