[1]

Shao Y, Wang Y, Yuan Y, Xie Y. 2021. A systematic review on antibiotics misuse in livestock and aquaculture and regulation implications in China. Science of the Total Environment 798:149205

doi: 10.1016/j.scitotenv.2021.149205
[2]

Kavya IK, Kochhar N, Ghosh A, Shrivastava S, Singh Rawat V, et al. 2023. Perspectives on systematic generation of antibiotic resistance with special emphasis on modern antibiotics. Total Environment Research Themes 8:100068

doi: 10.1016/j.totert.2023.100068
[3]

WHO. 2015. Global Action Plan on Antimicrobial Resistance. Geneva: World Health Organization. pp. 1–19 www.unep.org/resources/report/global-action-plan-antimicrobial-resistance

[4]

Liu N, Zhang L, Xue H, Yang Z, Meng F. 2025. Sources, dissemination, and risk assessment of antibiotic resistance in surface waters: a review. Emerging Contaminants 11:100455

doi: 10.1016/j.emcon.2024.100455
[5]

Meng Q, Zhang Y, He D, Xia Y, Fu J, et al. 2025. Metagenomic perspectives on antibiotic resistance genes in tap water: the environmental characteristic, potential mobility and health threat. Journal of Environmental Sciences 147:582−596

doi: 10.1016/j.jes.2023.12.023
[6]

Wang S, Nie W, Gu Q, Wang X, Yang D, et al. 2024. Spread of antibiotic resistance genes in drinking water reservoirs: Insights from a deep metagenomic study using a curated database. Water Research 256:121572

doi: 10.1016/j.watres.2024.121572
[7]

Wang C, Yang H, Liu H, Zhang XX, Ma L. 2023. Anthropogenic contributions to antibiotic resistance gene pollution in household drinking water revealed by machine-learning-based source-tracking. Water Research 246:120682

doi: 10.1016/j.watres.2023.120682
[8]

Sanganyado E, Gwenzi W. 2019. Antibiotic resistance in drinking water systems: occurrence, removal, and human health risks. Science of the Total Environment 669:785−797

doi: 10.1016/j.scitotenv.2019.03.162
[9]

Coleman BL, Louie M, Salvadori MI, McEwen SA, Neumann N, et al. 2013. Contamination of Canadian private drinking water sources with antimicrobial resistant Escherichia coli. Water Research 47:3026−3036

doi: 10.1016/j.watres.2013.03.008
[10]

Bergeron S, Boopathy R, Nathaniel R, Corbin A, LaFleur G. 2015. Presence of antibiotic resistant bacteria and antibiotic resistance genes in raw source water and treated drinking water. International Biodeterioration & Biodegradation 102:370−374

doi: 10.1016/j.ibiod.2015.04.017
[11]

Su HC, Liu YS, Pan CG, Chen J, He LY, et al. 2018. Persistence of antibiotic resistance genes and bacterial community changes in drinking water treatment system: from drinking water source to tap water. Science of the Total Environment 616-617:453−461

doi: 10.1016/j.scitotenv.2017.10.318
[12]

Han Z, Zhang Y, An W, Lu J, Hu J, et al. 2020. Antibiotic resistomes in drinking water sources across a large geographical scale: multiple drivers and co-occurrence with opportunistic bacterial pathogens. Water Research 183:116088

doi: 10.1016/j.watres.2020.116088
[13]

Hu Y, Jin L, Zhao Y, Jiang L, Yao S, et al. 2021. Annual trends and health risks of antibiotics and antibiotic resistance genes in a drinking water source in East China. Science of the Total Environment 791:148152

doi: 10.1016/j.scitotenv.2021.148152
[14]

Guo ZF, Boeing WJ, Xu YY, Borgomeo E, Liu D, et al. 2023. Data-driven discoveries on widespread contamination of freshwater reservoirs by dominant antibiotic resistance genes. Water Research 229:119466

doi: 10.1016/j.watres.2022.119466
[15]

Zhang G, Zhang C, Liu J, Zhang Y, and Fu W. 2024. Occurrence, fate, and risk assessment of antibiotics in conventional and advanced drinking water treatment systems: from source to tap. Journal of Environmental Management 358:120746

doi: 10.1016/j.jenvman.2024.120746
[16]

Xu L, Ouyang W, Qian Y, Su C, Su J, et al. 2016. High-throughput profiling of antibiotic resistance genes in drinking water treatment plants and distribution systems. Environmental Pollution 213:119−126

doi: 10.1016/j.envpol.2016.02.013
[17]

Guo X, Li J, Yang F, Yang J, Yin D. 2014. Prevalence of sulfonamide and tetracycline resistance genes in drinking water treatment plants in the Yangtze River Delta, China. Science of the Total Environment 493:626−631

doi: 10.1016/j.scitotenv.2014.06.035
[18]

Ding H, Wu Y, Zhang W, Zhong J, Lou Q, et al. 2017. Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China. Chemosphere 184:137−147

doi: 10.1016/j.chemosphere.2017.05.148
[19]

Liang X, Guan F, Chen B, Luo P, Guo C, et al. 2020. Spatial and seasonal variations of antibiotic resistance genes and antibiotics in the surface waters of Poyang Lake in China. Ecotoxicology and Environmental Safety 196:110543

doi: 10.1016/j.ecoenv.2020.110543
[20]

Li JL, Wang Y, Dong YH, Wang M, Zhao QL, et al. 2022. Distribution characteristics and ecological risk assessment of typical antibiotics in Yuanhe River of Poyang Lake Basin. Asian Journal of Ecotoxicology 17:563−574 (in Chinese)

doi: 10.7524/AJE.1673-5897.20211130001
[21]

Zhang Z, Zhang Q, Wang T, Xu N, Lu T, et al. 2022. Assessment of global health risk of antibiotic resistance genes. Nature Communications 13:1553

doi: 10.1038/s41467-022-29283-8
[22]

Zhang Z, Li B, Li N, Sardar MF, Song T, et al. 2019. Effects of UV disinfection on phenotypes and genotypes of antibiotic-resistant bacteria in secondary effluent from a municipal wastewater treatment plant. Water Research 157:546−554

doi: 10.1016/j.watres.2019.03.079
[23]

Zhang QQ, Ying GG, Pan CG, Liu YS, Zhao JL. 2015. Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environmental Science & Technology 49:6772−6782

doi: 10.1021/acs.est.5b00729
[24]

Chen Y, Cui K, Huang Q, Guo Z, Huang Y, et al. 2020. Comprehensive insights into the occurrence, distribution, risk assessment and indicator screening of antibiotics in a large drinking reservoir system. Science of the Total Environment 716:137060

doi: 10.1016/j.scitotenv.2020.137060
[25]

Wang N, Wang N, Qi D, Kang G, Wang W, et al. 2023. Comprehensive overview of antibiotic distribution, risk and priority: a study of large-scale drinking water sources from the lower Yangtze River. Journal of Environmental Management 344:118705

doi: 10.1016/j.jenvman.2023.118705
[26]

Li F, Chen L, Chen W, Bao Y, Zheng Y, et al. 2020. Antibiotics in coastal water and sediments of the East China Sea: distribution, ecological risk assessment and indicators screening. Marine Pollution Bulletin 151:110810

doi: 10.1016/j.marpolbul.2019.110810
[27]

Zha DP, Feng ML, Chen HW, Liu ZG, Liao B, et al. 2015. Spatial-temporal changes of the typical wetland landscape of Poyang Lake. Journal of Hydroecology 36:1−7 (in Chinese)

doi: 10.15928/j.1674-3075.2015.05.001
[28]

Liu LL, Yang WJ, You QH, Jian MF, Liu DD, et al. 2020. Water quality assessment of Poyang Lake wetland using radar-type charts. Journal of Hydroecology 41:1−8 (in Chinese)

doi: 10.15928/j.1674-3075.2020.04.001
[29]

Yin F, Wang S, Zhang W, Cao Q, Lian T, et al. 2023. Sulfachloropyridazine (SCP) effects on anaerobic microorganisms and its degradation pathways. Chemical Engineering Journal 466:143049

doi: 10.1016/j.cej.2023.143049
[30]

Jia A, Wan Y, Xiao Y, Hu J. 2012. Occurrence and fate of quinolone and fluoroquinolone antibiotics in a municipal sewage treatment plant. Water Research 46:387−394

doi: 10.1016/j.watres.2011.10.055
[31]

Yu L, Song C, Zhang C, Fan L, Qiu L, et al. 2018. Occurrence of sulfonamides in fish in the lower reaches of Yangtze River, China and estimated daily intake for understanding human dietary exposure. Aquaculture 495:538−544

doi: 10.1016/j.aquaculture.2018.06.033
[32]

Zhou M, Yu S, Hong B, Li J, Han H, et al. 2021. Antibiotics control in aquaculture requires more than antibiotic-free feeds: a tilapia farming case. Environmental Pollution 268:115854

doi: 10.1016/j.envpol.2020.115854
[33]

Liu C, Lei J, Huang X, Liu X, Cai S, et al. 2026. Mechanistic insight into enhanced florfenicol degradation by micro-nano bubbles ozonation in mariculture wastewater. Environmental Research 301:124531

doi: 10.1016/j.envres.2026.124531
[34]

Zhang G, Lu S, Wang Y, Liu X, Liu Y, et al. 2020. Occurrence of antibiotics and antibiotic resistance genes and their correlations in lower Yangtze River, China. Environmental Pollution 257:113365

doi: 10.1016/j.envpol.2019.113365
[35]

Jiang L, Zhai W, Wang J, Li G, Zhou Z, et al. 2023. Antibiotics and antibiotic resistance genes in the water sources of the Wuhan stretch of the Yangtze River: occurrence, distribution, and ecological risks. Environmental Research 239:117295

doi: 10.1016/j.envres.2023.117295
[36]

Wang S, Fang L, Sun X, Lu W. 2024. Occurrence and distribution of antibiotic resistance genes in urban rivers with black-odor water of Harbin, China. Environmental Research 259:119497

doi: 10.1016/j.envres.2024.119497
[37]

Luo Y, Mao D, Rysz M, Zhang H, Xu L, et al. 2010. Trends in antibiotic resistance genes occurrence in the Haihe River, China. Environmental Science & Technology 44:7220−7225

doi: 10.1021/es100233w
[38]

Szekeres E, Chiriac CM, Baricz A, Szőke-Nagy T, Lung I, et al. 2018. Investigating antibiotics, antibiotic resistance genes, and microbial contaminants in groundwater in relation to the proximity of urban areas. Environmental Pollution 236:734−744

doi: 10.1016/j.envpol.2018.01.107
[39]

Chen J, Su Z, Dai T, Huang B, Mu Q, et al. 2019. Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea bays. Journal of Environmental Sciences 81:156−167

doi: 10.1016/j.jes.2019.01.016
[40]

Yang J, Wang H, Roberts DJ, Du HN, Yu XF, et al. 2020. Persistence of antibiotic resistance genes from river water to tap water in the Yangtze River Delta. Science of the Total Environment 742:140592

doi: 10.1016/j.scitotenv.2020.140592
[41]

Shi D, Yang Z, Wei Y, Miao J, Yang D, et al. 2023. Spatial and temporal analysis of the seasonal dynamics of antibiotic resistance gene occurrence in recreational marine water. Science of the Total Environment 893:164816

doi: 10.1016/j.scitotenv.2023.164816
[42]

Jiang S, Shi B, Zhu D, Cheng X, Zhou Z, et al. 2024. Cross-contamination and ecological risk assessment of antibiotics between rivers and surrounding open aquaculture ponds. Environmental Pollution 344:123404

doi: 10.1016/j.envpol.2024.123404
[43]

Chen Y, Su JQ, Zhang J, Li P, Chen H, et al. 2019. High-throughput profiling of antibiotic resistance gene dynamic in a drinking water river-reservoir system. Water Research 149:179−189

doi: 10.1016/j.watres.2018.11.007
[44]

Shu Q, Gao H, Li RJ, Chen HY, Na GS. 2024. The source and dissemination of ARGs in pristine environments: elucidating the role of migratory birds in the Arctic. Journal of Hazardous Materials 480:136272

doi: 10.1016/j.jhazmat.2024.136272
[45]

Lin Y, Dong X, Sun R, Wu J, Tian L, et al. 2020. Migratory birds-one major source of environmental antibiotic resistance around Qinghai Lake, China. Science of the Total Environment 739:139758

doi: 10.1016/j.scitotenv.2020.139758
[46]

Zhao Z, Zhang Y, Liu R, Wang L, Xu H, et al. 2023. Antibiotic resistance genes in constructed wetlands: driving indicators and risk assessment. Journal of Hazardous Materials 459:132314

doi: 10.1016/j.jhazmat.2023.132314
[47]

Sensi P. 1983. History of the development of rifampin. Reviews of Infectious Diseases 5:S402−S406

doi: 10.1093/clinids/5.Supplement_3.S402
[48]

Ding H, Wu Y, Zou B, Lou Q, Zhang W, et al. 2016. Simultaneous removal and degradation characteristics of sulfonamide, tetracycline, and quinolone antibiotics by laccase-mediated oxidation coupled with soil adsorption. Journal of Hazardous Materials 307:350−358

doi: 10.1016/j.jhazmat.2015.12.062
[49]

Erdoğan AN, Dasmeh P, Socha RD, Chen JZ, Life BE, et al. 2024. Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype. Nature Communications 15:10813

doi: 10.1038/s41467-024-55012-4
[50]

Hughes D, Andersson DI. 2017. Environmental and genetic modulation of the phenotypic expression of antibiotic resistance. FEMS Microbiology Reviews 41:374−391

doi: 10.1093/femsre/fux004