| [1] |
Pirmohamed M, James S, Meakin S, Green C, Scott AK, et al. 2004. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. |
| [2] |
Hayward S, Hole B, Denholm R, Duncan P, Morris JE, et al. 2021. International prescribing patterns and polypharmacy in older people with advanced chronic kidney disease: results from the European Quality study. |
| [3] |
Steinman MA, Hanlon JT. 2010. Managing medications in clinically complex elders: there's got to be a happy medium. |
| [4] |
Gurwitz JH, Field TS, Harrold LR, Rothschild J, Debellis K, et al. 2003. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. |
| [5] |
Turgeon J, Michaud V, Steffen L. 2017. The dangers of polypharmacy in elderly patients. |
| [6] |
Leopold JA, Loscalzo J. 2018. Emerging role of precision medicine in cardiovascular disease. |
| [7] |
Haga SB, Burke W. 2004. Using pharmacogenetics to improve drug safety and efficacy. |
| [8] |
Swen JJ, van der Wouden CH, Manson LE, Abdullah-Koolmees H, Blagec K, et al. 2023. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. |
| [9] |
van der Wouden CH, Bank PCD, Özokcu K, Swen JJ, Guchelaar HJ. 2019. Pharmacist-initiated pre-emptive pharmacogenetic panel testing with clinical decision support in primary care: record of PGx results and real-world impact. |
| [10] |
Bousman CA, Stevenson JM, Ramsey LB, Sangkuhl K, Hicks JK, et al. 2023. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants. |
| [11] |
Hicks JK, Swen JJ, Thorn CF, Sangkuhl K, Kharasch ED, et al. 2013. Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. |
| [12] |
Scott SA, Sangkuhl K, Gardner EE, Stein CM, Hulot JS, et al. 2011. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. |
| [13] |
Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, et al. 2021. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C19 and proton pump inhibitor dosing. |
| [14] |
Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, et al. 2017. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2C19 and voriconazole therapy. |
| [15] |
Huang Q, Liao Y, Yu T, Lei W, Liang H, et al. 2023. A retrospective analysis of preemptive pharmacogenomic testing in 22,918 individuals from China. |
| [16] |
Duarte JD, Dalton R, Elchynski AL, Smith DM, Cicali EJ, et al. 2021. Multisite investigation of strategies for the clinical implementation of pre-emptive pharmacogenetic testing. |
| [17] |
Weintraub WS, Fahed AC, Rumsfeld JS. 2018. Translational medicine in the era of big data and machine learning. |
| [18] |
Caraballo PJ, Sutton JA, Giri J, Wright JA, Nicholson WT, et al. 2020. Integrating pharmacogenomics into the electronic health record by implementing genomic indicators. |
| [19] |
Chenchula S, Atal S, Uppugunduri CRS. 2024. A review of real-world evidence on preemptive pharmacogenomic testing for preventing adverse drug reactions: a reality for future health care. |
| [20] |
Whirl-Carrillo M, Huddart R, Gong L, Sangkuhl K, Thorn CF, et al. 2021. An evidence-based framework for evaluating pharmacogenomics knowledge for personalized medicine. |
| [21] |
Sadee W, Wang D, Hartmann K, Toland AE. 2023. Pharmacogenomics: driving personalized medicine. |
| [22] |
Abdullah-Koolmees H, van Keulen AM, Nijenhuis M, Deneer VHM. 2020. Pharmacogenetics guidelines: overview and comparison of the DPWG, CPIC, CPNDS, and RNPGx guidelines. |
| [23] |
Chanfreau-coffinier C, Hull LE, Lynch JA, DuVall SL, Damrauer SM, et al. 2019. Projected prevalence of actionable pharmacogenetic variants and level A drugs prescribed among US Veterans Health Administration pharmacy users. |
| [24] |
Dunnenberger HM, Crews KR, Hoffman JM, Caudle KE, Broeckel U, et al. 2015. Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers. |
| [25] |
Liu D, Olson KL, Manzi SF, Mandl KD. 2021. Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. |
| [26] |
Ramsey LB, Ong HH, Schildcrout JS, Shi Y, Tang LA, et al. 2020. Prescribing prevalence of medications with potential genotype-guided dosing in pediatric patients. |
| [27] |
Smith DM, Peshkin BN, Springfield TB, Brown RP, Hwang E, et al. 2020. Pharmacogenetics in practice: estimating the clinical actionability of pharmacogenetic testing in perioperative and ambulatory settings. |
| [28] |
Yu S, Zhang Y, Yao Y, Cao H. 2020. Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database. |
| [29] |
国家统计局 [National Bureau of Statistics of China]. 2023. 东西中部和东北地区划分方法 [Division of China's eastern, central, western and northeastern regions]. www.stats.gov.cn/zt_18555/zthd/sjtjr/dejtjkfr/tjkp/202302/t20230216_1909741.htm (in Chinese) |
| [30] |
Kimpton JE, Carey IM, Threapleton CJD, Robinson A, Harris T, et al. 2019. Longitudinal exposure of English primary care patients to pharmacogenomic drugs: an analysis to inform design of pre-emptive pharmacogenomic testing. |
| [31] |
Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley JM, et al. 2012. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. |
| [32] |
广东省医疗保障局 [Healthcare Security Administration of Guangdong Province]. 2024. 广东省医疗保障局关于公布"药物基因多态性检测"等转归医疗服务价格项目的通知 [Notice of Guangdong Healthcare Security Administration on publishing the converted medical service price items such as 'pharmacogene polymorphism testing']. https://hsa.gd.gov.cn/zwgk/content/post_4608065.html (in Chinese) |
| [33] |
河北省医疗保障局 [Hebei Provincial Healthcare Security Administration]. 2024. 河北省城市公立医院医疗服务价格查询表 [Hebei Province urban public hospitals medical service price inquiry table]. https://ylbzj.hebei.gov.cn/cms/content/3351 (in Chinese) |
| [34] |
浙江省物价局, 浙江省卫生计生委, 浙江省人力资源和社会保障厅 [Price Bureau of Zhejiang Province, Health and Family Planning Commission of Zhejiang Province, Department of Human Resources and Social Security of Zhejiang Province]. 2019. 浙江省卫生计生委 浙江省人力资源和社会保障厅关于完善和新增部分医疗服务检验项目及价格等有关事项的通知 [Notice of the Zhejiang provincial authorities on improving and adding medical service testing items and prices]. http://ybj.zj.gov.cn/art/2019/11/6/art_1229113757_564072.html (in Chinese) |
| [35] |
Samwald M, Xu H, Blagec K, Empey PE, Malone DC, et al. 2016. Incidence of exposure of patients in the United States to multiple drugs for which pharmacogenomic guidelines are available. |
| [36] |
Mostafa S, Kirkpatrick CMJ, Byron K, Sheffield L. 2019. An analysis of allele, genotype and phenotype frequencies, actionable pharmacogenomic (PGx) variants and phenoconversion in 5,408 Australian patients genotyped for CYP2D6, CYP2C19, CYP2C9 and VKORC1 genes. |
| [37] |
Ji Y, Skierka JM, Blommel JH, Moore BE, VanCuyk DL, et al. 2016. Preemptive pharmacogenomic testing for precision medicine: a comprehensive analysis of five actionable pharmacogenomic genes using next-generation DNA sequencing and a customized CYP2D6 genotyping cascade. |
| [38] |
Lee CR, Luzum JA, Sangkuhl K, Gammal RS, Sabatine MS, et al. 2022. Clinical Pharmacogenetics Implementation Consortium guideline for CYP2C19 genotype and clopidogrel therapy: 2022 update. |
| [39] |
Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, et al. 2022. The Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and statin-associated musculoskeletal symptoms. |
| [40] |
Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, et al. 2017. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for pharmacogenetics-guided warfarin dosing: 2017 update. |
| [41] |
Theken KN, Lee CR, Gong L, Caudle KE, Formea CM, et al. 2020. Clinical Pharmacogenetics Implementation Consortium guideline (CPIC) for CYP2C9 and nonsteroidal anti-inflammatory drugs. |
| [42] |
Wang X, Yang S, Zhang J, Wang M, Zhang J, et al. 2022. Transformer-based unsupervised contrastive learning for histopathological image classification. |
| [43] |
Wang X, Du Y, Yang S, Zhang J, Wang M, et al. 2023. RetCCL: clustering-guided contrastive learning for whole-slide image retrieval. |
| [44] |
Wang X, Zhao J, Marostica E, Yuan W, Jin J, et al. 2024. A pathology foundation model for cancer diagnosis and prognosis prediction. |
| [45] |
Yuan W, Chen Y, Zhu B, Yang S, Zhang J, et al. 2025. Pancancer outcome prediction via a unified weakly supervised deep learning model. |
| [46] |
Cai D, Chen J, Zhao J, Xue Y, Yang S, et al. 2024. HiCervix: an extensive hierarchical dataset and benchmark for cervical cytology classification. |
| [47] |
Wang X, Zhang J, Yang S, Xiang J, Luo F, et al. 2023. A generalizable and robust deep learning algorithm for mitosis detection in multicenter breast histopathological images. |
| [48] |
Guo R, Xie K, Pagnucco M, Song Y. 2023. SAC-Net: learning with weak and noisy labels in histopathology image segmentation. |
| [49] |
Ding PA, Yang S, Meng LJ, Chen S, Li SP, et al. 2026. A multimodal deep learning model for preoperative prediction of post-operative complications in gastric cancer. |
| [50] |
Ianni BD, Yiu CH, Tan ECK, Lu CY. 2025. Real-world utilization of medications with pharmacogenetic recommendations in older adults: a scoping review. |
| [51] |
Lemke LK, Alam B, Williams R, Starostik P, Cavallari LH, et al. 2023. Reimbursement of pharmacogenetic tests at a tertiary academic medical center in the United States. |