| [1] |
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, et al. 2024. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. |
| [2] |
Fink H, Langselius O, Vignat J, Rumgay H, Rehm J, et al. 2026. Global and regional cancer burden attributable to modifiable risk factors to inform prevention. |
| [3] |
Sung H, Filho AM, Laversanne M, Ferlay J, Siegel RL, et al. 2026. Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries. |
| [4] |
World Health Organization. 2026. Global status report on cancer 2026: the future we choose together. Geneva: World Health Organization |
| [5] |
Rosenberg SA, Restifo NP. 2015. Adoptive cell transfer as personalized immunotherapy for human cancer. |
| [6] |
June CH, Sadelain M. 2018. Chimeric antigen receptor therapy. |
| [7] |
Chesney J, Lewis KD, Kluger H, Hamid O, Whitman E, et al. 2022. Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study. |
| [8] |
Hu L, Fan C, Bross P, Das A, Cho ES, et al. 2025. FDA approval summary: lifileucel for unresectable or metastatic melanoma previously treated with an anti-PD-1-based immunotherapy. |
| [9] |
Eshhar Z, Waks T, Gross G, Schindler DG. 1993. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. |
| [10] |
Chandran SS, Klebanoff CA. 2019. T cell receptor-based cancer immunotherapy: emerging efficacy and pathways of resistance. |
| [11] |
Munshi NC, Anderson LD Jr, Shah N, Madduri D, Berdeja J, et al. 2021. Idecabtagene vicleucel in relapsed and refractory multiple myeloma. |
| [12] |
Berdeja JG, Madduri D, Usmani SZ, Jakubowiak A, Agha M, et al. 2021. Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study. |
| [13] |
Roddie C, Sandhu KS, Tholouli E, Logan AC, Shaughnessy P, et al. 2024. Obecabtagene autoleucel in adults with B-cell acute lymphoblastic leukemia. |
| [14] |
Labanieh L, MacKall CL. 2023. CAR immune cells: design principles, resistance and the next generation. |
| [15] |
Rafiq S, Hackett CS, Brentjens RJ. 2020. Engineering strategies to overcome the current roadblocks in CAR T cell therapy. |
| [16] |
Sun F, Cheng Y, Wanchai V, Guo W, Mery D, et al. 2024. Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. |
| [17] |
Sun F, Cheng Y, Chen JR, Wanchai V, Mery DE, et al. 2024. BCMA- and CST6-specific CAR T cells lyse multiple myeloma cells and suppress murine osteolytic lesions. |
| [18] |
Escobar G, Berger TR, Maus MV. 2025. CAR-T cells in solid tumors: challenges and breakthroughs. |
| [19] |
Du B, Qin J, Lin B, Zhang J, Li D, et al. 2025. CAR-T therapy in solid tumors. |
| [20] |
Barnett KK, Johnson AR, Das A, Lee CJ, Wang C, et al. 2025. FDA approval summary: afamitresgene autoleucel for adults with HLA-restricted, MAGE-A4-positive unresectable or metastatic synovial sarcoma after prior chemotherapy. |
| [21] |
D'Angelo SP, Araujo DM, Abdul Razak AR, Agulnik M, Attia S, et al. 2024. Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial. |
| [22] |
Qi C, Liu C, Peng Z, Zhang Y, Wei J, et al. 2025. Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial. |
| [23] |
Wermke M, Araujo DM, Chatterjee M, Tsimberidou AM, Holderried TAW, et al. 2025. Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial. |
| [24] |
2026. First CAR T for solid tumors. Nature Biotechnology 44:1068 |
| [25] |
Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, et al. 2015. Tissue-based map of the human proteome. |
| [26] |
Majzner RG, Rietberg SP, Sotillo E, Dong R, Vachharajani VT, et al. 2020. Tuning the antigen density requirement for CAR T-cell activity. |
| [27] |
Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, et al. 2015. Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen receptor-modified effector CD8+ T cells. |
| [28] |
Huang J, Brameshuber M, Zeng X, Xie J, Li QJ, et al. 2013. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+ T cells. |
| [29] |
Consortium GT. 2020. The GTEx Consortium atlas of genetic regulatory effects across human tissues. |
| [30] |
Marcu A, Bichmann L, Kuchenbecker L, Kowalewski DJ, Freudenmann LK, et al. 2021. HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. |
| [31] |
Purcell AW, Ramarathinam SH, Ternette N. 2019. Mass spectrometry-based identification of MHC-bound peptides for immunopeptidomics. |
| [32] |
Yewdell JW. 2022. MHC class I immunopeptidome: past, present, and future. |
| [33] |
Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, et al. 2021. T cell circuits that sense antigen density with an ultrasensitive threshold. |
| [34] |
Olivier T, Haslam A, Tuia J, Prasad V. 2023. Eligibility for human leukocyte antigen-based therapeutics by race and ethnicity. |
| [35] |
Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, et al. 2017. Defining a cancer dependency map. |
| [36] |
Łuksza M, Riaz N, Makarov V, Balachandran VP, Hellmann MD, et al. 2017. A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy. |
| [37] |
Łuksza M, Sethna ZM, Rojas LA, Lihm J, Bravi B, et al. 2022. Neoantigen quality predicts immunoediting in survivors of pancreatic cancer. |
| [38] |
Leidner R, Sanjuan Silva N, Huang H, Sprott D, Zheng C, et al. 2022. Neoantigen T-cell receptor gene therapy in pancreatic cancer. |
| [39] |
Ely ZA, Kulstad ZJ, Gunaydin G, Addepalli S, Verzani EK, et al. 2025. Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition. |
| [40] |
Goncalves G, Dolcetti R, Ooi JD, Faridi P. 2025. Cryptic but critical: non-canonical antigens in cancer immunotherapy. |
| [41] |
Apavaloaei A, Zhao Q, Hesnard L, Cahuzac M, Durette C, et al. 2025. Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer. |
| [42] |
Bausch-Fluck D, Goldmann U, Müller S, van Oostrum M, Müller M, et al. 2018. The in silico human surfaceome. |
| [43] |
Sterner RC, Sterner RM. 2021. CAR-T cell therapy: current limitations and potential strategies. |
| [44] |
van der Stegen SJC, Hamieh M, Sadelain M. 2015. The pharmacology of second-generation chimeric antigen receptors. |
| [45] |
Chmielewski M, Abken H. 2015. TRUCKs: the fourth generation of CARs. |
| [46] |
Kagoya Y, Tanaka S, Guo T, Anczurowski M, Wang CH, et al. 2018. A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects. |
| [47] |
Dong D, Zheng L, Lin J, Zhang B, Zhu Y, et al. 2019. Structural basis of assembly of the human T cell receptor–CD3 complex. |
| [48] |
Gaud G, Lesourne R, Love PE. 2018. Regulatory mechanisms in T cell receptor signalling. |
| [49] |
Shah K, Al-Haidari A, Sun J, Kazi JU. 2021. T cell receptor (TCR) signaling in health and disease. |
| [50] |
Coulie PG, Van den Eynde BJ, van der Bruggen P, Boon T. 2014. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. |
| [51] |
He W, Cui K, Farooq MA, Huang N, Zhu S, et al. 2025. TCR-T cell therapy for solid tumors: challenges and emerging solutions. |
| [52] |
Bassani-Sternberg M, Pletscher-Frankild S, Jensen LJ, Mann M. 2015. Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation. |
| [53] |
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, et al. 2023. Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM. |
| [54] |
Stone JD, Chervin AS, Kranz DM. 2009. T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. |
| [55] |
Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A. 1995. Serial triggering of many T-cell receptors by a few peptide–MHC complexes. |
| [56] |
Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, et al. 2022. Tuning T cell receptor sensitivity through catch bond engineering. |
| [57] |
Ramakrishna S, Highfill SL, Walsh Z, Nguyen SM, Lei H, et al. 2019. Modulation of target antigen density improves CAR T-cell functionality and persistence. |
| [58] |
Orlando EJ, Han X, Tribouley C, Wood PA, Leary RJ, et al. 2018. Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia. |
| [59] |
Fry TJ, Shah NN, Orentas RJ, Stetler-Stevenson M, Yuan CM, et al. 2018. CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. |
| [60] |
Samur MK, Fulciniti M, Aktas Samur A, Bazarbachi AH, Tai YT, et al. 2021. Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma. |
| [61] |
Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, et al. 2013. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. |
| [62] |
Cameron BJ, Gerry AB, Dukes J, Harper JV, Kannan V, et al. 2013. Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. |
| [63] |
Rohaan MW, Borch TH, van den Berg JH, Met Ö, Kessels R, et al. 2022. Tumor-infiltrating lymphocyte therapy or ipilimumab in advanced melanoma. |
| [64] |
Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, et al. 2010. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. |
| [65] |
Simpson AJG, Caballero OL, Jungbluth A, Chen YT, Old LJ. 2005. Cancer/testis antigens, gametogenesis and cancer. |
| [66] |
Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, et al. 2011. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. |
| [67] |
Luke JJ, Warner AB, Chmielowski B, Diab A, Gebhardt C, et al. 2025. SUPRAME: a phase 3 trial comparing IMA203, an engineered T-cell receptor expressing T cell therapy (TCR-T) vs investigator's choice in patients with previously treated advanced cutaneous melanoma. |
| [68] |
Sigalotti L, Fratta E, Coral S, Tanzarella S, Danielli R, et al. 2004. Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine. |
| [69] |
Schumacher TN, Schreiber RD. 2015. Neoantigens in cancer immunotherapy. |
| [70] |
Parkhurst MR, Robbins PF, Tran E, Prickett TD, Gartner JJ, et al. 2019. Unique neoantigens arise from somatic mutations in patients with gastrointestinal cancers. |
| [71] |
Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, et al. 2016. T-cell transfer therapy targeting mutant KRAS in cancer. |
| [72] |
Kim SP, Vale NR, Zacharakis N, Krishna S, Yu Z, et al. 2022. Adoptive cellular therapy with autologous tumor-infiltrating lymphocytes and T-cell receptor-engineered T cells targeting common p53 neoantigens in human solid tumors. |
| [73] |
Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, et al. 2021. TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers. |
| [74] |
Doran SL, Stevanovic S, Adhikary S, Gartner JJ, Jia L, et al. 2019. T-cell receptor gene therapy for human papillomavirus-associated epithelial cancers: a first-in-human, phase I/II study. |
| [75] |
Straathof KCM, Bollard CM, Popat U, Huls MH, Lopez T, et al. 2005. Treatment of nasopharyngeal carcinoma with Epstein-Barr virus–specific T lymphocytes. |
| [76] |
Wu XA, Quan D, Li W, Wisskirchen K, Wu W, et al. 2026. Clinical results of an HBV-specific T-cell receptor-T-cell therapy (SCG101) in patients with HBV-related hepatocellular carcinoma treated in an investigator-initiated, interventional trial. |
| [77] |
Hansen UK, Church CD, Carnaz Simões AM, Frej MS, Bentzen AK, et al. 2024. T antigen-specific CD8+ T cells associate with PD-1 blockade response in virus-positive Merkel cell carcinoma. |
| [78] |
Cobbold M, De La Peña H, Norris A, Polefrone JM, Qian J, et al. 2013. MHC class I-associated phosphopeptides are the targets of memory-like immunity in leukemia. |
| [79] |
Zarling AL, Polefrone JM, Evans AM, Mikesh LM, Shabanowitz J, et al. 2006. Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy. |
| [80] |
Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, et al. 2016. Engineered CAR T cells targeting the cancer-associated tn-glycoform of the membrane mucin MUC1 control adenocarcinoma. |
| [81] |
Mount CW, Majzner RG, Sundaresh S, Arnold EP, Kadapakkam M, et al. 2018. Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas. |
| [82] |
Burr ML, Sparbier CE, Chan KL, Chan YC, Kersbergen A, et al. 2019. An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer. |
| [83] |
Cowan AJ, Pont MJ, Sather BD, Turtle CJ, Till BG, et al. 2023. γ-secretase inhibitor in combination with BCMA chimeric antigen receptor T-cell immunotherapy for individuals with relapsed or refractory multiple myeloma: a phase 1, first-in-human trial. |
| [84] |
Hundal J, Kiwala S, McMichael J, Miller CA, Xia H, et al. 2020. pVACtools: a computational toolkit to identify and visualize cancer neoantigens. |
| [85] |
Reynisson B, Alvarez B, Paul S, Peters B, Nielsen M. 2020. NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data. |
| [86] |
O'Donnell TJ, Rubinsteyn A, Laserson U. 2020. MHCflurry 2.0: improved pan-allele prediction of MHC class I-presented peptides by incorporating antigen processing. |
| [87] |
Yadav M, Jhunjhunwala S, Phung QT, Lupardus P, Tanguay J, et al. 2014. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. |
| [88] |
Chong C, Muller M, Pak H, Harnett D, Huber F, et al. 2020. Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes. |
| [89] |
Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS. 2009. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. |
| [90] |
Ouspenskaia T, Law T, Clauser KR, Klaeger S, Sarkizova S, et al. 2022. Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer. |
| [91] |
Yi X, Liao Y, Wen B, Li K, Dou Y, et al. 2021. caAtlas: an immunopeptidome atlas of human cancer. |
| [92] |
Lu T, Zhang Z, Zhu J, Wang Y, Jiang P, et al. 2021. Deep learning-based prediction of the T cell receptor–antigen binding specificity. |
| [93] |
Albert BA, Yang Y, Shao XM, Singh D, Smith KN, et al. 2023. Deep neural networks predict class I major histocompatibility complex epitope presentation and transfer learn neoepitope immunogenicity. |
| [94] |
Klebanoff CA, Chandran SS, Baker BM, Quezada SA, Ribas A. 2023. T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome. |
| [95] |
Hsiue EH, Wright KM, Douglass J, Hwang MS, Mog BJ, et al. 2021. Targeting a neoantigen derived from a common TP53 mutation. |
| [96] |
Douglass J, Hsiue EH, Mog BJ, Hwang MS, DiNapoli SR, et al. 2021. Bispecific antibodies targeting mutant RAS neoantigens. |
| [97] |
Dao T, Yan S, Veomett N, Pankov D, Zhou L, et al. 2013. Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. |
| [98] |
Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, et al. 2019. Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response. |
| [99] |
Liu Y, Liu G, Wang J, Zheng ZY, Jia L, et al. 2021. Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors. |
| [100] |
Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, et al. 2022. HLA-independent T cell receptors for targeting tumors with low antigen density. |
| [101] |
Hassan R, Butler M, O'Cearbhaill RE, Oh DY, Johnson M, et al. 2023. Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results. |
| [102] |
Liddy N, Bossi G, Adams KJ, Lissina A, Mahon TM, et al. 2012. Monoclonal TCR-redirected tumor cell killing. |
| [103] |
Nathan P, Hassel JC, Rutkowski P, Baurain JF, Butler MO, et al. 2021. Overall survival benefit with tebentafusp in metastatic uveal melanoma. |
| [104] |
Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, et al. 2023. Three-year overall survival with tebentafusp in metastatic uveal melanoma. |
| [105] |
Majzner RG, Mackall CL. 2018. Tumor antigen escape from CAR T-cell therapy. |
| [106] |
Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, et al. 2015. Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy. |
| [107] |
Gardner R, Wu D, Cherian S, Fang M, Hanafi LA, et al. 2016. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. |
| [108] |
Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, et al. 2019. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. |
| [109] |
O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, et al. 2017. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. |
| [110] |
McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, et al. 2017. Allele-specific HLA loss and immune escape in lung cancer evolution. |
| [111] |
Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, et al. 2016. Mutations associated with acquired resistance to PD-1 blockade in melanoma. |
| [112] |
Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan DN, et al. 2011. T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. |
| [113] |
Van Oekelen O, Aleman A, Upadhyaya B, Schnakenberg S, Madduri D, et al. 2021. Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy. |
| [114] |
Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, et al. 2013. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. |
| [115] |
Bendle GM, Linnemann C, Hooijkaas AI, Bies L, de Witte MA, et al. 2010. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. |
| [116] |
Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, et al. 2015. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. |
| [117] |
Liu X, Jiang S, Fang C, Yang S, Olalere D, et al. 2015. Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice. |
| [118] |
Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, et al. 2015. Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity. |
| [119] |
Wermke M, Alsdorf W, Araujo DM, Busse A, Chatterjee M, et al. 2025. Phase 1 clinical update of IMA203, an autologous TCR-T targeting PRAME in patients with PD1 refractory metastatic melanoma. |
| [120] |
Kloss CC, Condomines M, Cartellieri M, Bachmann M, Sadelain M. 2013. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. |
| [121] |
Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, et al. 2016. Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. |
| [122] |
Fedorov VD, Themeli M, Sadelain M. 2013. PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. |
| [123] |
Hwang MS, Mog BJ, Douglass J, Pearlman AH, Hsiue EH, et al. 2021. Targeting loss of heterozygosity for cancer-specific immunotherapy. |
| [124] |
Cho JH, Collins JJ, Wong WW. 2018. Universal chimeric antigen receptors for multiplexed and logical control of T cell responses. |
| [125] |
Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, et al. 2016. Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape. |
| [126] |
Cohen CJ, Zhao Y, Zheng Z, Rosenberg SA, Morgan RA. 2006. Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. |
| [127] |
Kuball J, Dossett ML, Wolfl M, Ho WY, Voss RH, et al. 2007. Facilitating matched pairing and expression of TCR chains introduced into human T cells. |
| [128] |
Schober K, Müller TR, Gökmen F, Grassmann S, Effenberger M, et al. 2019. Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function. |
| [129] |
Eyquem J, Mansilla-Soto J, Giavridis T, van der Stegen SJC, Hamieh M, et al. 2017. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. |
| [130] |
Pegram HJ, Lee JC, Hayman EG, Imperato GH, Tedder TF, et al. 2012. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. |
| [131] |
Chmielewski M, Abken H. 2017. CAR T cells releasing IL-18 convert to T-Bethigh FoxO1low effectors that exhibit augmented activity against advanced solid tumors. |
| [132] |
Rai S, Wang S, Sun B, Kearl T, Hematti P, et al. 2026. Abstract 1520: improving BCMA-targeted CAR-T cell therapy of myeloma using TGF-β resistance and inducible production of IL-18. |
| [133] |
Narayan V, Barber-Rotenberg JS, Jung IY, Lacey SF, Rech AJ, et al. 2022. PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial. |
| [134] |
Lynn RC, Weber EW, Sotillo E, Gennert D, Xu P, et al. 2019. C-Jun overexpression in CAR T cells induces exhaustion resistance. |
| [135] |
Doan AE, Mueller KP, Chen AY, Rouin GT, Chen Y, et al. 2024. FOXO1 is a master regulator of memory programming in CAR T cells. |
| [136] |
Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, et al. 2020. CRISPR-engineered T cells in patients with refractory cancer. |
| [137] |
Chiesa R, Georgiadis C, Syed F, Zhan H, Etuk A, et al. 2023. Base-edited CAR7 T cells for relapsed T-cell acute lymphoblastic leukemia. |
| [138] |
Chiesa R, Georgiadis C, Rashed H, Preece R, Hardefeldt P, et al. 2025. Universal base-edited CAR7 T cells for T-cell acute lymphoblastic leukemia. |
| [139] |
Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, et al. 2022. CAR T cells produced in vivo to treat cardiac injury. |
| [140] |
Hunter TL, Bao Y, Zhang Y, Matsuda D, Riener R, et al. 2025. In vivo CAR T cell generation to treat cancer and autoimmune disease. |
| [141] |
Rodriguez-Garcia A, Lynn RC, Poussin M, Eiva MA, Shaw LC, et al. 2021. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. |
| [142] |
Mateus-Tique J, Lakshmi A, Singh B, Iyer R, Sánchez-Paulete AR, et al. 2026. Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth. |
| [143] |
Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, et al. 2020. Human chimeric antigen receptor macrophages for cancer immunotherapy. |
| [144] |
Reiss KA, Angelos MG, Dees EC, Yuan Y, Ueno NT, et al. 2025. CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial. |
| [145] |
Jumper J, Evans R, Pritzel A, Green T, Figurnov M, et al. 2021. Highly accurate protein structure prediction with AlphaFold. |
| [146] |
Abramson J, Adler J, Dunger J, Evans R, Green T, et al. 2024. Accurate structure prediction of biomolecular interactions with AlphaFold 3. |
| [147] |
Lin Z, Akin H, Rao R, Hie B, Zhu Z, et al. 2023. Evolutionary-scale prediction of atomic-level protein structure with a language model. |
| [148] |
Watson JL, Juergens D, Bennett NR, Trippe BL, Yim J, et al. 2023. De novo design of protein structure and function with RFdiffusion. |
| [149] |
Dauparas J, Anishchenko I, Bennett N, Bai H, Ragotte RJ, et al. 2022. Robust deep learning-based protein sequence design using ProteinMPNN. |
| [150] |
Bradley P. 2023. Structure-based prediction of T cell receptor: peptide-MHC interactions. |
| [151] |
Householder KD, Xiang X, Jude KM, Deng A, Obenaus M, et al. 2025. De novo design and structure of a peptide-centric TCR mimic binding module. |
| [152] |
Johansen KH, Wolff DS, Scapolo B, Fernández-Quintero ML, Risager Christensen C, et al. 2025. De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells. |
| [153] |
Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. 2015. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. |
| [154] |
Li HS, Israni DV, Gagnon KA, Gan KA, Raymond MH, et al. 2022. Multidimensional control of therapeutic human cell function with synthetic gene circuits. |
| [155] |
Teixeira AP, Fussenegger M. 2024. Synthetic gene circuits for regulation of next-generation cell-based therapeutics. |
| [156] |
Theodoris CV, Xiao L, Chopra A, Chaffin MD, Al Sayed ZR, et al. 2023. Transfer learning enables predictions in network biology. |
| [157] |
Tsahouridis O, Xu M, Song F, Savoldo B, Dotti G. 2025. The landscape of CAR-engineered innate immune cells for cancer immunotherapy. |
| [158] |
Liu E, Marin D, Banerjee P, Macapinlac HA, Thompson P, et al. 2020. Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors. |
| [159] |
Heczey A, Xu X, Courtney AN, Tian G, Barragan GA, et al. 2023. Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results. |
| [160] |
Liu X, Xu Y, Xiong W, Yin B, Huang Y, et al. 2022. Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy. |
| [161] |
Kantarjian H, Stein A, Gökbuget N, Fielding AK, Schuh AC, et al. 2017. Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia. |
| [162] |
Moreau P, Garfall AL, van de Donk NWCJ, Nahi H, San-Miguel JF, et al. 2022. Teclistamab in relapsed or refractory multiple myeloma. |
| [163] |
Chari A, Minnema Mc, Berdeja JG, Oriol A, van de Donk NWCJ, et al. 2022. Talquetamab, a T-cell–redirecting GPRC5D bispecific antibody for multiple myeloma. |
| [164] |
Shah NN, Johnson BD, Schneider D, Zhu F, Szabo A, et al. 2020. Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial. |
| [165] |
Ramos CA, Grover NS, Beaven AW, Lulla PD, Wu MF, et al. 2020. Anti-CD30 CAR-T cell therapy in relapsed and refractory Hodgkin lymphoma. |
| [166] |
Majzner RG, Ramakrishna S, Yeom KW, Patel S, Chinnasamy H, et al. 2022. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. |
| [167] |
Monje M, Mahdi J, Majzner R, Yeom KW, Schultz LM, et al. 2025. Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas. |
| [168] |
Majzner RG, Theruvath JL, Nellan A, Heitzeneder S, Cui Y, et al. 2019. CAR T cells targeting B7-H3, a pan-cancer antigen, demonstrate potent preclinical activity against pediatric solid tumors and brain tumors. |
| [169] |
Vitanza NA, Ronsley R, Choe M, Seidel K, Huang W, et al. 2025. Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial. |
| [170] |
Zhu H, Fang X, Tuhin IJ, Tan J, Ye J, et al. 2022. CAR T cells equipped with a fully human scFv targeting Trop2 can be used to treat pancreatic cancer. |
| [171] |
Feng Z, He X, Zhang X, Wu Y, Xing B, et al. 2022. Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues. |
| [172] |
Pal SK, Tran B, Haanen JBAG, Hurwitz ME, Sacher A, et al. 2024. CD70-targeted allogeneic CAR T-cell therapy for advanced clear cell renal cell carcinoma. |
| [173] |
Baumeister SH, Murad J, Werner L, Daley H, Trebeden-Negre H, et al. 2019. Phase I trial of autologous CAR T cells targeting NKG2D ligands in patients with AML/MDS and multiple myeloma. |
| [174] |
Wang Y, Chen M, Wu Z, Tong C, Dai H, et al. 2018. CD133-directed CAR T cells for advanced metastasis malignancies: a phase I trial. |
| [175] |
Heslop HE, Sharma S, Rooney CM. 2021. Adoptive T-cell therapy for Epstein-Barr virus-related lymphomas. |
| [176] |
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, et al. 2018. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. |
| [177] |
Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, et al. 2017. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. |
| [178] |
Wang M, Munoz J, Goy A, Locke FL, Jacobson CA, et al. 2020. KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma. |
| [179] |
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, et al. 2020. Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. |
| [180] |
Britton K, Mahat U, Richardson NC, Tegenge M, Gao Q, et al. 2025. FDA approval summary: lisocabtagene maraleucel for relapsed or refractory follicular lymphoma. |
| [181] |
Schmitz F, Schumacher M, Heine A, Busch A, Heine M, et al. 2024. Sequential dosing of next-generation IMA203CD8 TCR-T-cell therapy targeting PRAME in combination with BRAF-/MEK-inhibition in a melanoma patient with progressive disease - a case report. |