[1]

do Valle IF, Roweth HG, Malloy MW, Moco S, Barron D, et al. 2021. Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols. Nature Food 2:143−155

doi: 10.1038/s43016-021-00243-7
[2]

Wang Y, Wang C, Shi J, Zhang Y. 2024. Effects of derivatization and probiotic transformation on the antioxidative activity of fruit polyphenols. Food Chemistry: X 23:101776

doi: 10.1016/j.fochx.2024.101776
[3]

Jiang K, Bai Y, Hou R, Chen G, Liu L, et al. 2025. Advances in dietary polyphenols: regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis. Food Chemistry 472:142932

doi: 10.1016/j.foodchem.2025.142932
[4]

Tang X, Peng X. 2025. The gut microbiota-polyphenol interplay and its role in gut-organ axes: from mechanisms to functional outcomes. Trends in Food Science & Technology 163:105192

doi: 10.1016/j.tifs.2025.105192
[5]

Dai J, Tang W, Zhang J, Kang X, Dai W, et al. 2024. Determination and quality evaluation of active ingredients in areca nut using near-infrared rapid detection technology. Microchemical Journal 196:109586

doi: 10.1016/j.microc.2023.109586
[6]

Sari LM, Hakim RF, Mubarak Z, Andriyanto A. 2020. Analysis of phenolic compounds and immunomodulatory activity of areca nut extract from Aceh, Indonesia, against Staphylococcus aureus infection in Sprague-Dawley rats. Veterinary World 13:134−140

doi: 10.14202/vetworld.2020.134-140
[7]

Cheng F, Chen W, Huang Y, Zhang C, Shen Y, et al. 2011. Protective effect of areca inflorescence extract on hydrogen peroxide-induced oxidative damage to human serum albumin. Food Research International 44:98−102

doi: 10.1016/j.foodres.2010.11.005
[8]

Sartinah A, Nugrahani I, Ibrahim S, Anggadiredja K. 2022. Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: a review. Heliyon 8:e12039

doi: 10.1016/j.heliyon.2022.e12039
[9]

Mei F, Meng K, Gu Z, Yun Y, Zhang W, et al. 2021. Arecanut (Areca catechu L.) seed polyphenol-ameliorated osteoporosis by altering gut microbiome via LYZ and the immune system in estrogen-deficient rats. Journal of Agricultural and Food Chemistry 69:246−258

doi: 10.1021/acs.jafc.0c06671
[10]

Dolgikh OV, Dianova DG, Shirinkina AS, Bombela TV. 2024. Immunomodulatory properties of plant polyphenols shown in an in vitro experimental model. Medical Immunology (Russia) 26:143−150

doi: 10.15789/1563-0625-IPO-2655
[11]

Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. 2024. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Molecular Medicine 30:170

doi: 10.1186/s10020-024-00929-1
[12]

Cao Z, Rao H, Yang W, Hu X, Kang X, et al. 2025. Luteolin mitigates acute lung injury through immune modulation and antinecroptosis effects by targeting the BTK and FLT3 signaling pathways. Journal of Agricultural and Food Chemistry 73:5180−5193

doi: 10.1021/acs.jafc.4c06704
[13]

Cao Q, Ding S, Zheng X, Li H, Yu L, et al. 2025. Luteolin induces GPX4-dependent ferroptosis and enhances immune activation in colon cancer. Phytomedicine 146:157117

doi: 10.1016/j.phymed.2025.157117
[14]

Chou WW, Guh JY, Tsai JF, Hwang CC, Chen HC, et al. 2008. Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes. Toxicology 243:1−10

doi: 10.1016/j.tox.2007.09.003
[15]

Huang Z, He Z, Dong L, Li D, Chen F, et al. 2025. Microbial signatures of areca nut chewing: bridging the gap between oral dysbiosis and submucous fibrosis. Phytomedicine 147:157227

doi: 10.1016/j.phymed.2025.157227
[16]

Zhao J, Shi J, Chen X, Lei Y, Tian T, et al. 2024. Development and application of mass spectrometric molecular networking for analyzing the ingredients of areca nut. Molecular Omics 20:192−202

doi: 10.1039/d3mo00232b
[17]

Zhang Y, He Y, Yuan L, Shi J, Zhao J, et al. 2024. Multi-omics revealed anti-fatigue property of polyphenol from areca nut. Phytomedicine 132:155838

doi: 10.1016/j.phymed.2024.155838
[18]

Sari EF, Prayogo GP, Loo YT, Zhang P, McCullough MJ, et al. 2020. Distinct phenolic, alkaloid and antioxidant profile in betel quids from four regions of Indonesia. Scientific Reports 10:16254

doi: 10.1038/s41598-020-73337-0
[19]

Wu Q, Yang Y, Simon JE. 2007. Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). Chemistry & Biodiversity 4:2817−2826

doi: 10.1002/cbdv.200790231
[20]

Xu JY, Zhang C, Wang X, Zhai L, Ma Y, et al. 2020. Integrative proteomic characterization of human lung adenocarcinoma. Cell 182:245−261.e17

doi: 10.1016/j.cell.2020.05.043
[21]

Santosuosso M, Divangahi M, Zganiacz A, Xing Z. 2002. Reduced tissue macrophage population in the lung by anticancer agent cyclophosphamide: restoration by local granulocyte macrophage-colony-stimulating factor gene transfer. Blood 99:1246−1252

doi: 10.1182/blood.v99.4.1246
[22]

Wang Q, Wang C, Abdullah, Tian W, Qiu Z, et al. 2022. Hydroxytyrosol alleviates dextran sulfate sodium-induced colitis by modulating inflammatory responses, intestinal barrier, and microbiome. Journal of Agricultural and Food Chemistry 70:2241−2252

doi: 10.1021/acs.jafc.1c07568
[23]

Webb CR, den Bakker H, Koboziev I, Jones-Hall Y, Kottapalli KR, et al. 2018. Differential susceptibility to T cell-induced colitis in mice: role of the intestinal microbiota. Inflammatory Bowel Diseases 24:361−379

doi: 10.1093/ibd/izx014
[24]

Li Y, Zheng J, Wang Y, Yang H, Cao L, et al. 2023. Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota. International Journal of Biological Macromolecules 242:124789

doi: 10.1016/j.ijbiomac.2023.124789
[25]

Zhang YW, Liu S, Zhang X, Li WB, Chen Y, et al. 2009. A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron 64:328−340

doi: 10.1016/j.neuron.2009.08.036
[26]

Wang Q, Chen G, Liu L, Peng X, Yang X, et al. 2024. MRPS23 is a novel prognostic biomarker and promotes glioma progression. Aging (Albany NY) 16:2457−2474

doi: 10.18632/aging.205493
[27]

Tran DH, Kim D, Kesavan R, Brown H, Dey T, et al. 2024. De novo and salvage purine synthesis pathways across tissues and tumors. Cell 187:3602−3618.e20

doi: 10.1016/j.cell.2024.05.011
[28]

Zhang Y, Chen Y, Zhang Y, Zhang Q, Wang L, et al. 2026. Natural polyphenols in the treatment of IBD: pathological intervention activities and delivery system constructions. Food Research International 232:118760

doi: 10.1016/j.foodres.2026.118760
[29]

Davydov DR, Prasad B. 2021. Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism. Trends in Pharmacological Sciences 42:988−997

doi: 10.1016/j.tips.2021.09.004
[30]

Uduwana S, Abeynayake N, Wickramasinghe I. 2023. Synergistic, antagonistic, and additive effects on the resultant antioxidant activity in infusions of green tea with bee honey and Citrus limonum extract as additives. Journal of Agriculture and Food Research 12:100571

doi: 10.1016/j.jafr.2023.100571
[31]

Peter Ebokaiwe A, Olachi Obasi D, Kalu WO. 2022. Abatement of cyclophosphamide-induced splenic immunosuppressive indoleamine 2, 3-dioxygenase and altered hematological indices in Wister rats by dietary quercetin. Immunobiology 227:152218

doi: 10.1016/j.imbio.2022.152218
[32]

Zheng X, Li H, Zhang M, Qiu Z, Yang X, et al. 2026. Discovery and mutasynthetic optimization of ansatrienin B: a new broad-spectrum inhibitor against RNA viruses. Acta Pharmaceutica Sinica B 16(6):3963−3984

doi: 10.1016/j.apsb.2026.02.021
[33]

Li Y, Xia H, Wu M, Wang J, Lu X, et al. 2017. Evaluation of the antibacterial effects of flavonoid combination from the leaves of Dracontomelon dao by microcalorimetry and the quadratic rotary combination design. Frontiers in Pharmacology 8:70

doi: 10.3389/fphar.2017.00070
[34]

Ozdal T, Sela DA, Xiao J, Boyacioglu D, Chen F, et al. 2016. The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients 8:78

doi: 10.3390/nu8020078
[35]

Dong YJ, Lin MQ, Fang X, Xie ZY, Luo R, et al. 2022. Modulating effects of a functional food containing Dendrobium officinale on immune response and gut microbiota in mice treated with cyclophosphamide. Journal of Functional Foods 94:105102

doi: 10.1016/j.jff.2022.105102
[36]

Han K, Ahn Y, Hong KB, Suh HJ, Yu KW, et al. 2022. Ameliorating the efficacy of galacto-oligosaccharides on ovalumin-induced allergic dermatitis symptoms in Balb/c mice by regulating Th2 immune response and the ecosystem of gut microbiota. Food & Function 13:6271−6281

doi: 10.1039/d2fo00157h
[37]

Bang S, Shin YH, Ma X, Park SM, Graham DB, et al. 2023. A cardiolipin from Muribaculum intestinale induces antigen-specific cytokine responses. Journal of the American Chemical Society 145:23422−23426

doi: 10.1021/jacs.3c09734
[38]

Zhang J, Zhou HC, He SB, Zhang XF, Ling YH, et al. 2021. The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice. Food & Function 12:7954−7963

doi: 10.1039/d1fo01257f
[39]

Song Y, Cai Q, Wang S, Li L, Wang Y, et al. 2022. The ameliorative effect and mechanisms of Ruditapes philippinarum bioactive peptides on obesity and hyperlipidemia induced by a high-fat diet in mice. Nutrients 14:5066

doi: 10.3390/nu14235066
[40]

Sharma S, Gibbons A, Saphire EO. 2025. Sex differences in tissue-specific immunity and immunology. Science 389:599−603

doi: 10.1126/science.adx4381