| [1] |
Durand D, Collin A, Merlot E, Baéza E, Guilloteau LA, et al. 2022. Review: Implication of redox imbalance in animal health and performance at critical periods, insights from different farm species. |
| [2] |
Villeneuve G, Roy C, Deschêne K, Matte JJ, Lapointe J, et al. 2025. Effects of increasing dietary zinc oxide levels on the hepatic mitochondrial energy metabolism, oxidative balance, and antioxidant system in weaned piglets. |
| [3] |
Li Q, Yang S, Chen F, Guan W, Zhang S. 2022. Nutritional strategies to alleviate oxidative stress in sows. |
| [4] |
Zheng P, Yu B, He J, Yu J, Mao X, et al. 2017. Arginine metabolism and its protective effects on intestinal health and functions in weaned piglets under oxidative stress induced by diquat. |
| [5] |
Cao S, Wu H, Wang C, Zhang Q, Jiao L, et al. 2018. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. |
| [6] |
Ghawi SK, Methven L, Niranjan K. 2013. The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var. italica) using mustard seeds (Sinapis alba). |
| [7] |
Suez J, Cohen Y, Valdés-Mas R, Mor U, Dori-Bachash M, et al. 2022. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. |
| [8] |
Cramer JM, Jeffery EH. 2011. Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men. |
| [9] |
Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, et al. 2015. Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase‐treated broccoli sprout extract. |
| [10] |
Mahn A, Castillo A. 2021. Potential of sulforaphane as a natural immune system enhancer: a review. |
| [11] |
Kensler TW, Wakabayashi N, Biswal S. 2007. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. |
| [12] |
Houghton CA. 2019. Sulforaphane: its "coming of age" as a clinically relevant nutraceutical in the prevention and treatment of chronic disease. |
| [13] |
Warwick E, Cassidy A, Hanley B, Jouni ZE, Bao Y. 2012. Effect of phytochemicals on phase II enzyme expression in infant human primary skin fibroblast cells. |
| [14] |
Bonnesen C, Eggleston IM, Hayes JD. 2001. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Research 61:6120−30 |
| [15] |
Georgikou C, Yin L, Gladkich J, Xiao X, Sticht C, et al. 2020. Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer. |
| [16] |
Xu Y, Han X, Li Y, Min H, Zhao X, et al. 2019. Sulforaphane mediates glutathione depletion via polymeric nanoparticles to restore cisplatin chemosensitivity. |
| [17] |
Hossain S, Liu Z, Wood RJ. 2020. Histone deacetylase activity and vitamin D‐dependent gene expressions in relation to sulforaphane in human breast cancer cells. |
| [18] |
Ishiura Y, Ishimaru H, Watanabe T, Fujimuro M. 2019. Sulforaphane exhibits cytotoxic effects against primary effusion lymphoma cells by suppressing p38MAPK and AKT phosphorylation. |
| [19] |
Wu DM, Zheng ZH, Fan SH, Zhang ZF, Chen GQ, et al. 2020. Sulforaphane administration alleviates diffuse axonal injury (DAI) via regulation signaling pathway of NRF2 and HO‐1. |
| [20] |
Carrasco-Pozo C, Tan KN, Rodriguez T, Avery VM. 2019. The molecular effects of sulforaphane and capsaicin on metabolism upon androgen and Tip60 activation of androgen receptor. |
| [21] |
Lin LC, Yeh CT, Kuo CC, Lee CM, Yen GC, et al. 2012. Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function. |
| [22] |
Santín-Márquez R, Alarcón-Aguilar A, López-Diazguerrero NE, Chondrogianni N, Königsberg M. 2019. Sulforaphane-role in aging and neurodegeneration. |
| [23] |
Zeren S, Bayhan Z, Kocak FE, Kocak C, Akcılar R, et al. 2016. Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid-induced gastric ulcer in rats. |
| [24] |
Jiang LL, Zhou SJ, Zhang XM, Chen HQ, Liu W. 2016. Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity. |
| [25] |
Atwell LL, Beaver LM, Shannon J, Williams DE, Dashwood RH, et al. 2015. Epigenetic regulation by sulforaphane: opportunities for breast and prostate cancer chemoprevention. |
| [26] |
Clarke JD, Riedl K, Bella D, Schwartz SJ, Stevens JF, et al. 2011. Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. |
| [27] |
Hussain S, Gupta G, Shahwan M, Bansal P, Kaur H, et al. 2024. Non-coding RNA: a key regulator in the Glutathione-GPX4 pathway of ferroptosis. |
| [28] |
Kang KA, Piao MJ, Fernando PDSM, Herath HMUL, Boo HJ, et al. 2024. Oxidative stress-mediated RUNX3 mislocalization occurs via Jun activation domain-binding protein 1 and histone modification. |
| [29] |
Greer EL, Shi Y. 2012. Histone methylation: a dynamic mark in health, disease and inheritance. |
| [30] |
Barnes CE, English DM, Cowley SM. 2019. Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription. |
| [31] |
Hyun K, Jeon J, Park K, Kim J. 2017. Writing, erasing and reading histone lysine methylations. |
| [32] |
Ito K, Hanazawa T, Tomita K, Barnes PJ, Adcock IM. 2004. Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. |
| [33] |
Niu Y, DesMarais TL, Tong Z, Yao Y, Costa M. 2015. Oxidative stress alters global histone modification and DNA methylation. |
| [34] |
Wang S, Peng X, Zhu Q, Lu S, Hu P, et al. 2025. Lithocholic acid attenuates DON-induced inflammatory responses via epigenetic regulation of DUSP5 and TRAF5 in porcine intestinal epithelial cells. |
| [35] |
Sivandzade F, Prasad S, Bhalerao A, Cucullo L. 2019. NRF2 and NF-κB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches. |
| [36] |
Cascajosa-Lira A, Prieto AI, Pichardo S, Jos A, Cameán AM. 2024. Protective effects of sulforaphane against toxic substances and contaminants: a systematic review. |
| [37] |
Shang Q, Liu H, Wu D, Mahfuz S, Piao X. 2021. Source of fiber influences growth, immune responses, gut barrier function and microbiota in weaned piglets fed antibiotic-free diets. |
| [38] |
Farahat M, Ibrahim D, Kishawy ATY, Abdallah HM, Hernandez-Santana A, et al. 2021. Effect of cereal type and plant extract addition on the growth performance, intestinal morphology, caecal microflora, and gut barriers gene expression of broiler chickens. |
| [39] |
Walton KD, Freddo AM, Wang S, Gumucio DL. 2016. Generation of intestinal surface: an absorbing tale. |
| [40] |
Modina SC, Polito U, Rossi R, Corino C, Di Giancamillo A. 2019. Nutritional regulation of gut barrier integrity in weaning piglets. |
| [41] |
Wang M, Huang H, Hu Y, Liu Y, Zeng X, et al. 2020. Effects of dietary supplementation with herbal extract mixture on growth performance, organ weight and intestinal morphology in weaning piglets. |
| [42] |
Su G, Zhou X, Wang Y, Chen D, Chen G, et al. 2020. Dietary supplementation of plant essential oil improves growth performance, intestinal morphology and health in weaned pigs. |
| [43] |
Lu H, Zhao W, Zhang B, Xie Y, He J, et al. 2024. Construction and validation of an oxidative phosphorylation signature in high‐grade glioma and potential inhibitors screening. |
| [44] |
Zhang R, Neuhoff C, Yang Q, Cinar MU, Uddin MJ, et al. 2022. Sulforaphane enhanced proliferation of porcine satellite cells via epigenetic augmentation of SMAD7. |
| [45] |
Fleishman JS, Kumar S. 2024. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets. |
| [46] |
Nakayama N, Yamaguchi S, Sasaki Y, Chikuma T. 2016. Hydrogen peroxide-induced oxidative stress activates proteasomal trypsin-like activity in human U373 glioma cells. |
| [47] |
Zhao H, Tian M, Xiong L, Lin T, Zhang S, et al. 2023. Maternal supplementation with glycerol monolaurate improves the intestinal health of suckling piglets by inhibiting the NF-κB/MAPK pathways and improving oxidative stability. |
| [48] |
Nissanka N, Moraes CT. 2018. Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. |
| [49] |
Olufunmilayo EO, Gerke-Duncan MB, Holsinger RM. 2023. Oxidative stress and antioxidants in neurodegenerative disorders. |
| [50] |
Enayati AA, Ranson H, Hemingway J. 2005. Insect glutathione transferases and insecticide resistance. |
| [51] |
Li X, Tang L, Deng J, Qi X, Zhang J, et al. 2022. Identifying metabolic reprogramming phenotypes with glycolysis-lipid metabolism discoordination and intercellular communication for lung adenocarcinoma metastasis. |
| [52] |
Ma Y, Temkin SM, Hawkridge AM, Guo C, Wang W, et al. 2018. Fatty acid oxidation: an emerging facet of metabolic transformation in cancer. |
| [53] |
Wang C, Shao L, Pan C, Ye J, Ding Z, et al. 2019. Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition. |
| [54] |
Chandimali N, Bak SG, Park EH, Lim HJ, Won YS, et al. 2025. Free radicals and their impact on health and antioxidant defenses: a review. |
| [55] |
Schieber M, Chandel NS. 2014. ROS function in redox signaling and oxidative stress. |
| [56] |
Liu HY, Gu H, Li Y, Hu P, Yang Y, et al. 2021. Dietary conjugated linoleic acid modulates the hepatic circadian clock program via PPARα/REV-ERBα-mediated chromatin modification in mice. |
| [57] |
Bougarne N, Weyers B, Desmet SJ, Deckers J, Ray DW, et al. 2018. Molecular actions of PPARα in lipid metabolism and inflammation. |
| [58] |
Kong S, Zhang YH, Zhang W. 2018. Regulation of intestinal epithelial cells properties and functions by amino acids. |
| [59] |
Parmar G, Fong-McMaster C, Pileggi CA, Patten DA, Cuillerier A, et al. 2024. Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation. |
| [60] |
Whitaker HC, Patel D, Howat WJ, Warren AY, Kay JD, et al. 2013. Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress. |
| [61] |
Wang SF, Tseng LM, Lee HC. 2023. Role of mitochondrial alterations in human cancer progression and cancer immunity. |
| [62] |
Bano D, Prehn JHM. 2018. Apoptosis-inducing factor (AIF) in physiology and disease: the tale of a repented natural born killer. |
| [63] |
Morton SU, Prabhu SP, Lidov HGW, Shi J, Anselm I, et al. 2017. AIFM1 mutation presenting with fatal encephalomyopathy and mitochondrial disease in an infant. |
| [64] |
Zhou W, Ji L, Liu X, Tu D, Shi N, et al. 2022. AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury. |
| [65] |
Gu H, Liu Y, Zhao Y, Qu H, Li Y, et al. 2023. Hepatic anti-oxidative genes CAT and GPX4 are epigenetically modulated by RORγ/NRF2 in alphacoronavirus-exposed piglets. |
| [66] |
Tang W, Zhong Y, Wei Y, Deng Z, Mao J, et al. 2022. Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets. |
| [67] |
Murugan AK, Alzahrani AS. 2022. Isocitrate dehydrogenase IDH1 and IDH2 mutations in human cancer: prognostic implications for gliomas. |
| [68] |
Robert McMaster W, Morrison CJ, Kobor MS. 2016. Epigenetics: a new model for intracellular parasite–host cell regulation. |
| [69] |
Barnes BM, Shyne A, Gunn DA, Griffiths CEM, Watson REB. 2024. Epigenetics and ultraviolet radiation: Implications for skin ageing and carcinogenesis. |
| [70] |
Li K, Li H, Zhang K, Zhang J, Hu P, et al. 2021. Orphan nuclear receptor RORγ modulates the genome-wide binding of the cholesterol metabolic genes during mycotoxin-induced liver injury. |