| [1] |
Wang X, Pei Y, Wu J, Zhong X, Liu H, et al. 2025. Innovative mycelium-based food: advancing One Health through nutritional insights and environmental sustainability. |
| [2] |
Kominiarek MA, Rajan P. 2016. Nutrition recommendations in pregnancy and lactation. |
| [3] |
Goodnight W, Newman R, Society of Maternal–Fetal Medicine. 2009. Optimal nutrition for improved twin pregnancy outcome. |
| [4] |
Cal-Pereyra L, Dibarrat JA, Benech A, Da Silva S, Martin A, et al. 2012. Toxemia de la gestación en ovejas: revisión. Revista Mexicana de Ciencias Pecuarias 2:247−64 |
| [5] |
Hoang AN. 2019. Undernutrition during pregnancy. In Complications of Pregnancy. ed. Abduljabbar HS. London: IntechOpen doi: 10.5772/intechopen.82727 |
| [6] |
Rush D. 2000. Nutrition and maternal mortality in the developing world. |
| [7] |
Saeed Q, Shah N, Inam S, Shafique K. 2017. Maternal depressive symptoms and child nutritional status: a cross-sectional study in socially disadvantaged Pakistani community. |
| [8] |
Wu G, Bazer FW, Wallace JM, Spencer TE. 2006. Board-invited review: intrauterine growth retardation: implications for the animal sciences. |
| [9] |
Abu-Saad K, Fraser D. 2010. Maternal nutrition and birth outcomes. |
| [10] |
Stein AD, Zybert PA, van de Bor M, Lumey LH. 2004. Intrauterine famine exposure and body proportions at birth: the Dutch Hunger Winter. |
| [11] |
Bhutta ZA, Darmstadt GL, Hasan BS, Haws RA. 2005. Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence. |
| [12] |
Gao F, Hou X, Liu Y. 2007. Effect of hormonal status and metabolic changes of restricted ewes during late pregnancy on their fetal growth and development. |
| [13] |
Gluckman PD, Cutfield W, Hofman P, Hanson MA. 2005. The fetal, neonatal, and infant environments-the long-term consequences for disease risk. |
| [14] |
Cal L, Borteiro C, Benech A, Rodas E, Abreu MN, et al. 2009. Histological changes of the liver and metabolic correlates in ewes with pregnancy toxemia. |
| [15] |
Wang M, Li E, Wang G. 2014. Histopathological analysis of liver during pregnancy toxemia in small-tailed han sheep. Agricultural Science & Technology 3:470−73 |
| [16] |
Victora CG, Adair L, Fall C, Hallal PC, Martorell R, et al. 2008. Maternal and child undernutrition: consequences for adult health and human capital. |
| [17] |
Mikolajczak A, Sallam NA, Singh RD, Scheidl TB, Walsh EJ, et al. 2021. Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction. |
| [18] |
Bagchi DP, Nishii A, Li Z, DelProposto JB, Corsa CA, et al. 2020. Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells. |
| [19] |
Xue Y, Guo C, Hu F, Zhu W, Mao S. 2019. Maternal undernutrition induces fetal hepatic lipid metabolism disorder and affects the development of fetal liver in a sheep model. |
| [20] |
Rani V, Deep G, Singh RK, Palle K, Yadav UCS. 2016. Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. |
| [21] |
Xue YF, Guo CZ, Hu F, Sun DM, Liu JH, et al. 2019. Molecular mechanisms of lipid metabolism disorder in livers of ewes with pregnancy toxemia. |
| [22] |
Wesolowski SR, El Kasmi KC, Jonscher KR, Friedman JE. 2017. Developmental origins of NAFLD: a womb with a clue. |
| [23] |
Wells JC, Sawaya AL, Wibaek R, Mwangome M, Poullas MS, et al. 2020. The double burden of malnutrition: aetiological pathways and consequences for health. |
| [24] |
Lumey LH, Stein AD, Kahn HS, van der Pal-de Bruin KM, Blauw GJ, et al. 2007. Cohort profile: the Dutch Hunger Winter families study. |
| [25] |
Redmer DA, Wallace JM, Reynolds LP. 2004. Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development. |
| [26] |
Wallace JM, Luther JS, Milne JS, Aitken RP, Redmer DA, et al. 2006. Nutritional modulation of adolescent pregnancy outcome − a review. |
| [27] |
Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D. 2016. Diet before and during pregnancy and offspring health: the importance of animal models and what can be learned from them. |
| [28] |
Stevens CE, Hume ID. 1998. Contributions of microbes in vertebrate gastrointestinal tract to production and conservation of nutrients. |
| [29] |
Levenson SM, Crowley LV, Horowitz RE, Malm OJ. 1959. The metabolism of carbon-labeled urea in the germfree rat. |
| [30] |
von Engelhardt W, Hinderer S, Rechkemmer G, Becker G. 1984. Urea secretion into the colon of sheep and goat. |
| [31] |
McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JL, et al. 2008. Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition. |
| [32] |
Ye J, DeBose-Boyd RA. 2011. Regulation of cholesterol and fatty acid synthesis. |
| [33] |
Postic C, Dentin R, Denechaud PD, Girard J. 2007. ChREBP, a transcriptional regulator of glucose and lipid metabolism. |
| [34] |
Brickner AE, Pires JAA, Gressley TF, Grummer RR. 2009. Effects of abomasal lipid infusion on liver triglyceride accumulation and adipose lipolysis during fatty liver induction in dairy cows. |
| [35] |
Syed-Abdul MM, Moore MP, Wheeler AA, Ganga RR, Diaz-Arias A, et al. 2023. Isotope labeling and biochemical assessment of liver-triacylglycerol in patients with different levels of histologically-graded liver disease. |
| [36] |
Bansal SK, Bansal MB. 2024. Pathogenesis of MASLD and MASH − role of insulin resistance and lipotoxicity. |
| [37] |
Kawano Y, Cohen DE. 2013. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. |
| [38] |
Simard JR, Kamp F, Hamilton JA. 2008. Measuring the adsorption of fatty acids to phospholipid vesicles by multiple fluorescence probes. |
| [39] |
Thompson BR, Lobo S, Bernlohr DA. 2010. Fatty acid flux in adipocytes: the in's and out's of fat cell lipid trafficking. |
| [40] |
Lavoie JM, Gauthier MS. 2006. Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. |
| [41] |
Zakaria Z, Othman ZA, Nna VU, Mohamed M. 2023. The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets. |
| [42] |
Shiozaki M, Kanno K, Yonezawa S, Otani Y, Shigenobu Y, et al. 2024. Integrator complex subunit 6 promotes hepatocellular steatosis via β-catenin-PPARγ axis. |
| [43] |
Wernig F, Born S, Boles E, Grininger M, Oreb M. 2020. Fusing α and β subunits of the fungal fatty acid synthase leads to improved production of fatty acids. |
| [44] |
Tan H, Mi N, Tong F, Zhang R, Abudurexiti A, et al. 2024. Lactucopicrin promotes fatty acid β-oxidation and attenuates lipid accumulation through adenosine monophosphate-activated protein kinase activation in free fatty acid-induced human hepatoblastoma cancer cells. |
| [45] |
Wei H, Weaver YM, Yang C, Zhang Y, Hu G, et al. 2024. Proteolytic activation of fatty acid synthase signals pan-stress resolution. |
| [46] |
Adewuyi AA, Gruys E, van Eerdenburg FM. 2005. Non esterified fatty acids (NEFA) in dairy cattle. A review. |
| [47] |
Zhang G, Deighan A, Raj A, Robinson L, Donato HJ, et al. 2022. Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice. |
| [48] |
Loor JJ, Everts RE, Bionaz M, Dann HM, Morin DE, et al. 2007. Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. |
| [49] |
Lkhagvadorj S, Qu L, Cai W, Couture OP, Barb CR, et al. 2010. Gene expression profiling of the short-term adaptive response to acute caloric restriction in liver and adipose tissues of pigs differing in feed efficiency. |
| [50] |
Bertolesi GE, Chilije MFJ, Li V, Thompson CC, López-Villalobos A, et al. 2023. Differential eye expression of xenopus acyltransferase gnpat and its biochemical characterization shed light on lipid-associated ocular pathologies. |
| [51] |
Kamemoto Y, Hikage R, Han Y, Sekiya Y, Sawasato K, et al. 2023. Coordinated upregulation of two CDP-diacylglycerol synthases, YnbB and CdsA, is essential for cell growth and membrane protein export in the cold. |
| [52] |
Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, et al. 2007. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. International Journal of Molecular Medicine 20:351−58 |
| [53] |
Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, et al. 2000. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. |
| [54] |
Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, et al. 2024. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. |
| [55] |
Hikage R, Sekiya Y, Sawasato K, Nishiyama KI. 2024. CdsA, a CDP-diacylglycerol synthase involved in phospholipid and glycolipid MPIase biosynthesis, possesses multiple initiation codons. |
| [56] |
Santoshi M, Bansia H, Hussain M, Jha AK, Nagaraja V. 2024. Identification of a 1-acyl-glycerol-3-phosphate acyltransferase from Mycobacterium tuberculosis, a key enzyme involved in triacylglycerol biosynthesis. |
| [57] |
Ghaderi S, Levkau B. 2023. An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter. |
| [58] |
Blades F, Yazici AT, Cater RJ, Mancia F. 2025. MFSD2A in focus: the molecular mechanism of omega-3 fatty acid transport. |
| [59] |
Desvergne B, Michalik L, Wahli W. 2006. Transcriptional regulation of metabolism. |
| [60] |
Langley-Evans SC. 2006. Developmental programming of health and disease. |
| [61] |
Salter AM, Tarling EJ, Langley-Evans SC. 2009. Influence of maternal nutrition on the metabolic syndrome and cardiovascular risk in the offspring. |
| [62] |
Krebs N, Bagby S, Bhutta ZA, Dewey K, Fall C, et al. 2017. International summit on the nutrition of adolescent girls and young women: consensus statement. |
| [63] |
Gao F, Liu Y, Li L, Li M, Zhang C, et al. 2014. Effects of maternal undernutrition during late pregnancy on the development and function of ovine fetal liver. |
| [64] |
Liu X, Wang J, Gao L, Jiao Y, Liu C. 2018. Maternal protein restriction induces alterations in hepatic unfolded protein response-related molecules in adult rat offspring. |
| [65] |
Parimi PS, Cripe-Mamie C, Kalhan SC. 2004. Metabolic responses to protein restriction during pregnancy in rat and translation initiation factors in the mother and fetus. |
| [66] |
Martínez-Botas J, Suárez Y, Ferruelo AJ, Gómez-Coronado D, Lasuncion MA. 1999. Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2. |
| [67] |
Suárez Y, Fernández C, Ledo B, Ferruelo AJ, Martín M, et al. 2002. Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription. |
| [68] |
Herrera E, Amusquivar E, López-Soldado I, Ortega H. 2006. Maternal lipid metabolism and placental lipid transfer. |
| [69] |
Vance DE, Vance JE. 1996. Biochemistry of Lipids, Lipoproteins and Membranes. 3rd Edition. Amsterdam: Elsevier. www.sciencedirect.com/bookseries/new-comprehensive-biochemistry/vol/31/suppl/C |
| [70] |
Wellner N, Diep TA, Janfelt C, Hansen HS. 2013. N-acylation of phosphatidylethanolamine and its biological functions in mammals. |
| [71] |
Pizer ES, Chrest FJ, DiGiuseppe JA, Han WF. 1998. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Research 58:4611−15 |
| [72] |
Bandyopadhyay S, Zhan R, Wang Y, Pai SK, Hirota S, et al. 2006. Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. |
| [73] |
Nelson ME, Lahiri S, Chow JDY, Byrne FL, Hargett SR, et al. 2017. Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. |
| [74] |
Artwohl M, Roden M, Waldhäusl W, Freudenthaler A, Baumgartner-Parzer SM. 2004. Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. |
| [75] |
Liu Y, Ma C, Li H, Li L, Gao F, et al. 2017. Effects of intrauterine growth restriction during late pregnancy on the cell apoptosis and related gene expression in ovine fetal liver. |
| [76] |
Zi Y, Ma C, He S, Yang H, Zhang M, et al. 2022. Effects of intrauterine growth restriction during late pregnancy on the cell growth, proliferation, and differentiation in ovine fetal thymuses. |
| [77] |
Hancock ML, Meyer RC, Mistry M, Khetani RS, Wagschal A, et al. 2019. Insulin receptor associates with promoters genome-wide and regulates gene expression. |
| [78] |
Montaigne D, Butruille L, Staels B. 2021. PPAR control of metabolism and cardiovascular functions. |
| [79] |
Zhang Z, Liang X, Tong L, Lv Y, Yi H, et al. 2021. Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice. |
| [80] |
Li X, Yeh V, Molteni V. 2010. Liver X receptor modulators: a review of recently patented compounds (2007−2009). |
| [81] |
Xue Y, Guo C, Hu F, Zhu W, Mao S. 2020. Undernutrition-induced lipid metabolism disorder triggers oxidative stress in maternal and fetal livers using a model of pregnant sheep. |
| [82] |
Kersten S, Stienstra R. 2017. The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. |
| [83] |
Pyper SR, Viswakarma N, Yu S, Reddy JK. 2010. PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. |
| [84] |
la Cour Poulsen L, Siersbæk M, Mandrup S. 2012. PPARs: fatty acid sensors controlling metabolism. |
| [85] |
Hertz R, Bar-Tana J. 1992. Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes. |
| [86] |
Issemann I, Prince RA, Tugwood JD, Green S. 1993. The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor. |
| [87] |
Reddy JK, Hashimoto T. 2001. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. |
| [88] |
Kuhla B, Görs S, Metges CC. 2011. Hypothalamic orexin A expression and the involvement of AMPK and PPAR-gamma signalling in energy restricted dairy cows. |
| [89] |
Li P, Liu M, Long M, Guo Y, Wang Z, et al. 2013. Effect of β-hydroxybutyrate on expression of 3-hydroxy-3-methylglutaryl-CoA synthase in bovine hepatocytes cultured in vitro. Feed Industry 34(21):54−56 |
| [90] |
Ness GC, Chambers CM. 2000. Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity. |
| [91] |
Forbes JM, Coughlan MT, Cooper ME. 2008. Oxidative stress as a major culprit in kidney disease in diabetes. |
| [92] |
Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. 2009. The c-Jun N-terminal kinase mediates the induction of oxidative stress and insulin resistance by palmitate and toll-like receptor 2 and 4 ligands in 3T3-L1 adipocytes. |
| [93] |
Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, et al. 2006. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. |
| [94] |
Zhang Y, Cui Y, Wang XL, Shang X, Qi ZG, et al. 2015. PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats. |
| [95] |
Kurahashi T, Hamashima S, Shirato T, Lee J, Homma T, et al. 2015. An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy. |
| [96] |
Fernández-Miranda C, Pérez-Carreras M, Colina F, López-Alonso G, Vargas C, et al. 2008. A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease. |
| [97] |
Kumar DP, Caffrey R, Marioneaux J, Santhekadur PK, Bhat M, et al. 2020. The PPAR α/γ Agonist saroglitazar improves insulin resistance and steatohepatitis in a diet induced animal model of nonalcoholic fatty liver disease. |
| [98] |
Ratziu V, Harrison SA, Francque S, Bedossa P, Lehert P, et al. 2016. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. |