[1]

Mac Grory B, Schrag M, Biousse V, Furie KL, Gerhard-Herman M, et al. 2021. Management of central retinal artery occlusion: a scientific statement from the American heart association. Stroke 52:e282−e294

doi: 10.1161/STR.0000000000000366
[2]

Mathew B, Ravindran S, Liu X, Torres L, Chennakesavalu M, et al. 2019. Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion. Biomaterials 197:146−160

doi: 10.1016/j.biomaterials.2019.01.016
[3]

Li Y, Wen Y, Liu X, Li Z, Lin B, et al. 2022. Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury. Journal of Neuroinflammation 19:261

doi: 10.1186/s12974-022-02621-9
[4]

He S, Liu C, Ren C, Zhao H, Zhang X. 2024. Immunological landscape of retinal ischemia-reperfusion injury: insights into resident and peripheral immune cell responses. Aging and Disease 16:115−136

doi: 10.14336/ad.2024.0129
[5]

Chen D, Jiang H, Sun L, Nurzat Y, Qin H, et al. 2025. Neuron-targeted ROS-responsive liposomes for puerarin delivery remodel ischemic microenvironment via microglial modulation and neurovascular regeneration. Journal of Nanobiotechnology 23:677

doi: 10.1186/s12951-025-03730-2
[6]

Osborne NN, Casson RJ, Wood JPM, Chidlow G, Graham M, et al. 2004. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Progress in Retinal and Eye Research 23:91−147

doi: 10.1016/j.preteyeres.2003.12.001
[7]

Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, et al. 2015. Retinal microglia: just bystander or target for therapy? Progress in Retinal and Eye Research 45:30−57

doi: 10.1016/j.preteyeres.2014.11.004
[8]

Prinz M, Jung S, Priller J. 2019. Microglia biology: one century of evolving concepts. Cell 179:292−311

doi: 10.1016/j.cell.2019.08.053
[9]

Chen H, Deng Y, Gan X, Li Y, Huang W, et al. 2020. NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma. Molecular Neurodegeneration 15:26

doi: 10.1186/s13024-020-00372-w
[10]

Lähnemann D, Köster J, Szczurek E, McCarthy DJ, Hicks SC, et al. 2020. Eleven grand challenges in single-cell data science. Genome Biology 21:31

doi: 10.1186/s13059-020-1926-6
[11]

Tang F, Barbacioru C, Wang Y, Nordman E, Lee C, et al. 2009. mRNA-Seq whole-transcriptome analysis of a single cell. Nature Methods 6:377−382

doi: 10.1038/nmeth.1315
[12]

Burguillos MA, Svensson M, Schulte T, Boza-Serrano A, Garcia-Quintanilla A, et al. 2015. Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation. Cell Reports 10:1626−1638

doi: 10.1016/j.celrep.2015.02.012
[13]

Aubin JE, Gupta AK, Bhargava U, Turksen K. 1996. Expression and regulation of galectin 3 in rat osteoblastic cells. Journal of Cellular Physiology 169:468−480

doi: 10.1002/(SICI)1097-4652(199612)169:3<468::AID-JCP7>3.0.CO;2-M
[14]

Pavelka J, Voong CK, Schaal P, Lam MPY, Lau E. 2025. SALVE: prediction of interorgan communication with transcriptome latent space representation. American Journal of Physiology-Heart and Circulatory Physiology 329:H1621−H1632

doi: 10.1152/ajpheart.00637.2025
[15]

Bouffette S, Botez I, De Ceuninck F. 2023. Targeting galectin-3 in inflammatory and fibrotic diseases. Trends in Pharmacological Sciences 44:519−531

doi: 10.1016/j.tips.2023.06.001
[16]

Jiang Q, Zhao Q, Li P. 2025. Galectin-3 in metabolic disorders: mechanisms and therapeutic potential. Trends in Molecular Medicine 31:424−437

doi: 10.1016/j.molmed.2024.11.006
[17]

Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, et al. 2008. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 453:807−811

doi: 10.1038/nature06905
[18]

MacKinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, et al. 2012. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. American Journal of Respiratory and Critical Care Medicine 185:537−546

doi: 10.1164/rccm.201106-0965oc
[19]

Henderson NC, MacKinnon AC, Farnworth SL, Poirier F, Russo FP, et al. 2006. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proceedings of the National Academy of Sciences of the United States of America 103:5060−5065

doi: 10.1073/pnas.0511167103
[20]

Liu L, Chen F, Liu K, Xu F, Shen R, et al. 2025. The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury. International Journal of Biological Sciences 21:5802−5820

doi: 10.7150/ijbs.110790
[21]

Chi W, Li F, Chen H, Wang Y, Zhu Y, et al. 2014. Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma. Proceedings of the National Academy of Sciences of the United States of America 111:11181−11186

doi: 10.1073/pnas.1402819111
[22]

Lim HS, Qiu P. 2023. Quantifying cell-type-specific differences of single-cell datasets using uniform manifold approximation and projection for dimension reduction and shapley additive exPlanations. Journal of Computational Biology 30:738−750

doi: 10.1089/cmb.2022.0366
[23]

Griffith JW, Sokol CL, Luster AD. 2014. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annual Review of Immunology 32:659−702

doi: 10.1146/annurev-immunol-032713-120145
[24]

Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, et al. 2021. Inference and analysis of cell-cell communication using CellChat. Nature Communications 12:1088

doi: 10.1038/s41467-021-21246-9
[25]

Kermer P, Klöcker N, Labes M, Bähr M. 2000. Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo. The Journal of Neuroscience 20:722−728

doi: 10.1523/jneurosci.20-02-00722.2000
[26]

Ellezam B, Selles-Navarro I, Manitt C, Kennedy TE, McKerracher L. 2001. Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells. Experimental Neurology 168:105−115

doi: 10.1006/exnr.2000.7589
[27]

Calandra T, Roger T. 2003. Macrophage migration inhibitory factor: a regulator of innate immunity. Nature Reviews Immunology 3:791−800

doi: 10.1038/nri1200
[28]

Chidlow G, Wood JPM, Manavis J, Osborne NN, Casson RJ. 2008. Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries. Investigative Ophthalmology & Visual Science 49:762−771

doi: 10.1167/iovs.07-0726
[29]

Devanney NA, Stewart AN, Gensel JC. 2020. Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma. Experimental Neurology 329:113310

doi: 10.1016/j.expneurol.2020.113310
[30]

Orihuela R, McPherson CA, Harry GJ. 2016. Microglial M1/M2 polarization and metabolic states. British Journal of Pharmacology 173:649−665

doi: 10.1111/bph.13139
[31]

Mikawa T, Kameda M, Ikari S, Shibata E, Liu S, et al. 2025. Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions. Signal Transduction and Targeted Therapy 10:402

doi: 10.1038/s41392-025-02502-6
[32]

Jung HY, Kwon HJ, Kim W, Hahn KR, Moon SM, et al. 2020. Phosphoglycerate mutase 1 prevents neuronal death from ischemic damage by reducing neuroinflammation in the rabbit spinal cord. International Journal of Molecular Sciences 21:7425

doi: 10.3390/ijms21197425
[33]

Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, et al. 2012. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22:585−600

doi: 10.1016/j.ccr.2012.09.020
[34]

Zhou ZY, Chang TF, Lin ZB, Jing YT, Wen LS, et al. 2023. Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1. Cell Death & Disease 14:380

doi: 10.1038/s41419-023-05897-8
[35]

Manouchehrian O, Arnér K, Deierborg T, Taylor L. 2015. Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration. Journal of Neuroinflammation 12:92

doi: 10.1186/s12974-015-0312-x
[36]

Yu C, Lad EM, Mathew R, Shiraki N, Littleton S, et al. 2024. Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. Journal of Experimental Medicine 221:e20231011

doi: 10.1084/jem.20231011
[37]

García-Revilla J, Boza-Serrano A, Espinosa-Oliva AM, Soto MS, Deierborg T, et al. 2022. Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration. Cell Death & Disease 13:628

doi: 10.1038/s41419-022-05058-3
[38]

Hu T, Meng S, Zhang Q, Song S, Tan C, et al. 2022. Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury. Cell & Bioscience 12:196

doi: 10.1186/s13578-022-00932-1
[39]

Wu J, Zhang D, Liu H, Li J, Li T, et al. 2024. Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models. Journal of Translational Medicine 22:447

doi: 10.1186/s12967-024-05260-1
[40]

Qin Q, Yu N, Gu Y, Ke W, Zhang Q, et al. 2022. Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury. Cell Death & Disease 13:507

doi: 10.1038/s41419-022-04911-9
[41]

Dvoriantchikova G, Degterev A, Ivanov D. 2014. Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia – reperfusion-induced retinal damage. Experimental Eye Research 123:1−7

doi: 10.1016/j.exer.2014.04.009
[42]

Humphries DC, Mills R, Boz C, McHugh BJ, Hirani N, et al. 2022. Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation. Frontiers in Pharmacology 13:949264

doi: 10.3389/fphar.2022.949264
[43]

Madeira MH, Boia R, Santos PF, Ambrósio AF, Santiago AR. 2015. Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases. Mediators of Inflammation 2015:673090

doi: 10.1155/2015/673090
[44]

Gao C, Jiang J, Tan Y, Chen S. 2023. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal Transduction and Targeted Therapy 8:359

doi: 10.1038/s41392-023-01588-0
[45]

Masuda T, Sankowski R, Staszewski O, Prinz M. 2020. Microglia heterogeneity in the single-cell era. Cell Reports 30:1271−1281

doi: 10.1016/j.celrep.2020.01.010
[46]

Siew JJ, Chen HM, Chiu FL, Lee CW, Chang YM, et al. 2024. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. Journal of Clinical Investigation 134:e165523

doi: 10.1172/JCI165523
[47]

Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, et al. 2022. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity 55:1627−1644.e7

doi: 10.1016/j.immuni.2022.07.014
[48]

Silverman SM, Wong WT. 2018. Microglia in the retina: roles in development, maturity, and disease. Annual Review of Vision Science 4:45−77

doi: 10.1146/annurev-vision-091517-034425
[49]

Zhong X, Gong S, Meng L, Yao W, Du K, et al. 2024. Cordycepin modulates microglial M2 polarization coupled with mitochondrial metabolic reprogramming by targeting HKII and PDK2. Advanced Science 11:2304687

doi: 10.1002/advs.202304687
[50]

Wang S, Wang J, Hu Z, Wu L, Huang L. 2026. Role of glycolysis-mediated histone lactylation in microglial activation and progression of neurodegenerative diseases. Experimental Neurology 399:115663

doi: 10.1016/j.expneurol.2026.115663
[51]

Zhang Y, Wang X, Li D, Lu X, Gong Z, et al. 2026. TFAM-associated mitochondrial dynamics and metabolic reprogramming regulate microglial polarization: temporal and causal perspectives. The FASEB Journal 40:e71467

doi: 10.1096/fj.202503182RR
[52]

Zhou L, Xu Z, Lu H, Cho H, Xie Y, et al. 2024. Suppression of inner blood-retinal barrier breakdown and pathogenic Müller glia activation in ischemia retinopathy by myeloid cell depletion. Journal of Neuroinflammation 21:210

doi: 10.1186/s12974-024-03190-9
[53]

Kaur C, Foulds WS, Ling EA. 2008. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Progress in Retinal and Eye Research 27:622−647

doi: 10.1016/j.preteyeres.2008.09.003
[54]

Liu Y, Zhao C, Meng J, Li N, Xu Z, et al. 2022. Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-κB in experimental autoimmune uveitis. Clinical Immunology 236:108939

doi: 10.1016/j.clim.2022.108939