[1]

Mao H, Jiang C, Tang C, Nie X, Du L, et al. 2023. Wheat adaptation to environmental stresses under climate change: molecular basis and genetic improvement. Molecular Plant 16:1564−1589

doi: 10.1016/j.molp.2023.09.001
[2]

Li Y, Li L, Zhao M, Guo L, Guo X, et al. 2021. Wheat FRIZZY PANICLE activates VERNALIZATION1-A and HOMEOBOX4-A to regulate spike development in wheat. Plant Biotechnology Journal 19:1141−1154

doi: 10.1111/pbi.13535
[3]

Finnegan EJ, Ford B, Wallace X, Pettolino F, Griffin PT, et al. 2018. Zebularine treatment is associated with deletion of FT-B1 leading to an increase in spikelet number in bread wheat. Plant, Cell & Environment 41:1346−1360

doi: 10.1111/pce.13164
[4]

Luo X, Yang Y, Lin X, Xiao J. 2023. Deciphering spike architecture formation towards yield improvement in wheat. Journal of Genetics and Genomics 50:835−845

doi: 10.1016/j.jgg.2023.02.015
[5]

Kerbler SM, Wigge PA. 2023. Temperature sensing in plants. Annual Review of Plant Biology 74:341−366

doi: 10.1146/annurev-arplant-102820-102235
[6]

Kidokoro S, Shinozaki K, Yamaguchi-Shinozaki K. 2022. Transcriptional regulatory network of plant cold-stress responses. Trends in Plant Science 27:922−935

doi: 10.1016/j.tplants.2022.01.008
[7]

Melino V, Tester M. 2023. Salt-tolerant crops: time to deliver. Annual Review of Plant Biology 74:671−696

doi: 10.1146/annurev-arplant-061422-104322
[8]

Zhang Z, Huang J, Gao Y, Liu Y, Li J, et al. 2020. Suppressed ABA signal transduction in the spike promotes sucrose use in the stem and reduces grain number in wheat under water stress. Journal of Experimental Botany 71:7241−7256

doi: 10.1093/jxb/eraa380
[9]

Asseng S, Ewert F, Martre P, Rötter RP, Lobell DB, et al. 2015. Rising temperatures reduce global wheat production. Nature Climate Change 5:143−147

doi: 10.1038/nclimate2470
[10]

Frederiks TM, Christopher JT, Sutherland MW, Borrell AK. 2015. Post-head-emergence frost in wheat and barley: defining the problem, assessing the damage, and identifying resistance. Journal of Experimental Botany 66:3487−3498

doi: 10.1093/jxb/erv088
[11]

Yuan Z, Persson S, Zhang D. 2020. Molecular and genetic pathways for optimizing spikelet development and grain yield. aBIOTECH 1:276−292

doi: 10.1007/s42994-020-00026-x
[12]

Zhang D, Yuan Z. 2014. Molecular control of grass inflorescence development. Annual Review of Plant Biology 65:553−578

doi: 10.1146/annurev-arplant-050213-040104
[13]

Huang Y, Schnurbusch T. 2024. The birth and death of floral organs in cereal crops. Annual Review of Plant Biology 75:427−458

doi: 10.1146/annurev-arplant-060223-041716
[14]

Bonnett OT. 1936. The development of the wheat spike. Journal of Agricultural Research 53:445−451
[15]

Guo Z, Chen D, Röder MS, Ganal MW, Schnurbusch T. 2018. Genetic dissection of pre-anthesis sub-phase durations during the reproductive spike development of wheat. The Plant Journal 95(5):909−918

doi: 10.1111/tpj.13998
[16]

Li JY, Yang C, Xu J, Lu HP, Liu JX. 2023. The hot science in rice research: how rice plants cope with heat stress. Plant, Cell & Environment 46:1087−1103

doi: 10.1111/pce.14509
[17]

Yang Z, Cao Y, Shi Y, Qin F, Jiang C, et al. 2023. Genetic and molecular exploration of maize environmental stress resilience: toward sustainable agriculture. Molecular Plant 16:1496−1517

doi: 10.1016/j.molp.2023.07.005
[18]

Zhang W, Wang J, Huang Z, Mi L, Xu K, et al. 2019. Effects of low temperature at booting stage on sucrose metabolism and endogenous hormone contents in winter wheat spikelet. Frontiers in Plant Science 10:498

doi: 10.3389/fpls.2019.00498
[19]

Jiang G, Hassan MA, Muhammad N, Arshad M, Chen X, et al. 2022. Comparative physiology and transcriptome analysis of young spikes in response to late spring coldness in wheat (Triticum aestivum L.). Frontiers in Plant Science 13:811884

doi: 10.3389/fpls.2022.811884
[20]

Liu YJ, Li D, Gong J, Wang YB, Chen ZB, et al. 2021. Comparative transcriptome and DNA methylation analysis in temperature-sensitive genic male sterile wheat BS366. BMC Genomics 22:911

doi: 10.1186/s12864-021-08163-3
[21]

Tang Z, Zhang L, Xu C, Yuan S, Zhang F, et al. 2012. Uncovering small RNA-mediated responses to cold stress in a wheat thermosensitive genic male-sterile line by deep sequencing. Plant Physiology 159:721−738

doi: 10.1104/pp.112.196048
[22]

Díaz ML, Soresi DS, Basualdo J, Cuppari SJ, Carrera A. 2019. Transcriptomic response of durum wheat to cold stress at reproductive stage. Molecular Biology Reports 46:2427−2445

doi: 10.1007/s11033-019-04704-y
[23]

Kobayashi F. 2005. Regulation by Vrn-1/Fr-1 chromosomal intervals of CBF-mediated Cor/Lea gene expression and freezing tolerance in common wheat. Journal of Experimental Botany 56:887−895

doi: 10.1093/jxb/eri081
[24]

Dixon LE, Karsai I, Kiss T, Adamski NM, Liu Z, et al. 2019. VERNALIZATION1 controls developmental responses of winter wheat under high ambient temperatures. Development 146(3):dev172684

doi: 10.1242/dev.172684
[25]

Serrano L, Vazquez BN, Tischfield J. 2013. Chromatin structure, pluripotency and differentiation. Experimental Biology and Medicine (Maywood) 238:259−270

doi: 10.1177/1535370213480718
[26]

Dhillon T, Pearce SP, Stockinger EJ, Distelfeld A, Li C, et al. 2010. Regulation of freezing tolerance and flowering in temperate cereals: the VRN-1 connection. Plant Physiology 153:1846−1858

doi: 10.1104/pp.110.159079
[27]

Snape JW, Sarma R, Quarrie SA, Fish L, Galiba G, et al. 2001. Mapping genes for flowering time and frost tolerance in cereals using precise genetic stocks. Euphytica 120:309−315

doi: 10.1023/A:1017541505152
[28]

Soltész A, Smedley M, Vashegyi I, Galiba G, Harwood W, et al. 2013. Transgenic barley lines prove the involvement of TaCBF14 and TaCBF15 in the cold acclimation process and in frost tolerance. Journal of Experimental Botany 64:1849−1862

doi: 10.1093/jxb/ert050
[29]

Sun X, Hu C, Tan Q, Liu J, Liu H. 2009. Effects of molybdenum on expression of cold-responsive genes in abscisic acid (ABA)-dependent and ABA-independent pathways in winter wheat under low-temperature stress. Annals of Botany 104:345−356

doi: 10.1093/aob/mcp133
[30]

Tian S, Mao X, Zhang H, Chen S, Zhai C, et al. 2013. Cloning and characterization of TaSnRK2.3, a novel SnRK2 gene in common wheat. Journal of Experimental Botany 64:2063−2080

doi: 10.1093/jxb/ert072
[31]

Peng Y, Yang J, Li X, Zhang Y. 2021. Salicylic acid: biosynthesis and signaling. Annual Review of Plant Biology 72:761−791

doi: 10.1146/annurev-arplant-081320-092855
[32]

Siboza XI, Bertling I, Odindo AO. 2014. Salicylic acid and methyl jasmonate improve chilling tolerance in cold-stored lemon fruit (Citrus limon). Journal of Plant Physiology 171:1722−1731

doi: 10.1016/j.jplph.2014.05.012
[33]

Chen F, D'Auria JC, Tholl D, Ross JR, Gershenzon J, et al. 2003. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. The Plant Journal 36:577−588

doi: 10.1046/j.1365-313X.2003.01902.x
[34]

Chu W, Chang S, Lin J, Zhang C, Li J, et al. 2024. Methyltransferase TaSAMT1 mediates wheat freezing tolerance by integrating brassinosteroid and salicylic acid signaling. The Plant Cell 36:2607−2628

doi: 10.1093/plcell/koae100
[35]

Patidar A, Yadav MC, Kumari J, Tiwari S, Chawla G, et al. 2023. Identification of climate-smart bread wheat germplasm lines with enhanced adaptation to global warming. Plants 12(15):2851

doi: 10.3390/plants12152851
[36]

Pradhan S, Ali Babar M, Robbins K, Bai G, Mason RE, et al. 2019. Understanding the genetic basis of spike fertility to improve grain number, harvest index, and grain yield in wheat under high temperature stress environments. Frontiers in Plant Science 10:1481

doi: 10.3389/fpls.2019.01481
[37]

Touzy G, Lafarge S, Redondo E, Lievin V, Decoopman X, et al. 2022. Identification of QTLs affecting post-anthesis heat stress responses in European bread wheat. Theoretical and Applied Genetics 135:947−964

doi: 10.1007/s00122-021-04008-5
[38]

Draeger T, Moore G. 2017. Short periods of high temperature during meiosis prevent normal meiotic progression and reduce grain number in hexaploid wheat (Triticum aestivum L.). Theoretical and Applied Genetics 130:1785−1800

doi: 10.1007/s00122-017-2925-1
[39]

Ko CS, Kim JB, Hong MJ, Seo YW. 2021. Wheat (Triticum aestivum L.) TaHMW1D transcript variants are highly expressed in response to heat stress and in grains located in distal part of the spike. Plants 10(4):687

doi: 10.3390/plants10040687
[40]

Li D, Xiao Y, Guo L, Shan B, Liu X, et al. 2024. Effect of high nighttime temperatures on growth, yield, and quality of two wheat cultivars during the whole growth period. Plants 13(21):3071

doi: 10.3390/plants13213071
[41]

García GA, Dreccer MF, Miralles DJ, Serrago RA. 2015. High night temperatures during grain number determination reduce wheat and barley grain yield: a field study. Global Change Biology 21:4153−4164

doi: 10.1111/gcb.13009
[42]

Kumar Saini D, Hein NT, Somayanda I, Bheemanahalli R, Ostmeyer T, et al. 2025. Genetic mapping and haplotype analysis identify novel candidate genes for high night temperature tolerance in winter wheat. The Plant Genome 18:e70075

doi: 10.1002/tpg2.70075
[43]

Thomelin P, Bonneau J, Brien C, Suchecki R, Baumann U, et al. 2021. The wheat Seven in absentia gene is associated with increases in biomass and yield in hot climates. Journal of Experimental Botany 72:3774−3791

doi: 10.1093/jxb/erab044
[44]

Zhai H, Jiang C, Zhao Y, Yang S, Li Y, et al. 2021. Wheat heat tolerance is impaired by heightened deletions in the distal end of 4AL chromosomal arm. Plant Biotechnology Journal 19:1038−1051

doi: 10.1111/pbi.13529
[45]

Zhang R, Liu G, Xu H, Lou H, Zhai S, et al. 2022. Heat Stress Tolerance 2 confers basal heat stress tolerance in allohexaploid wheat (Triticum aestivum L.). Journal of Experimental Botany 73:6600−6614

doi: 10.1093/jxb/erac297
[46]

Tian X, Qin Z, Zhao Y, Wen J, Lan T, et al. 2022. Stress granule-associated TaMBF1c confers thermotolerance through regulating specific mRNA translation in wheat (Triticum aestivum). New Phytologist 233:1719−1731

doi: 10.1111/nph.17865
[47]

Suneja Y, Gupta AK, Chhuneja P, Bains NS. 2019. Molecular evolution and structural variations in nuclear encoded chloroplast localized heat shock protein 26 (sHSP26) from genetically diverse wheat species. Computational Biology and Chemistry 83:107144

doi: 10.1016/j.compbiolchem.2019.107144
[48]

Cao J, Qin Z, Cui G, Chen Z, Cheng X, et al. 2024. Natural variation of STKc_GSK3 kinase TaSG-D1 contributes to heat stress tolerance in Indian dwarf wheat. Nature Communications 15:2097

doi: 10.1038/s41467-024-46419-0
[49]

Hao XY, Yu TF, Peng CJ, Fu YH, Fang YH, et al. 2025. Somatic embryogenetic receptor kinase TaSERL2 regulates heat stress tolerance in wheat by influencing TaBZR2 protein stability and transcriptional activity. Plant Biotechnology Journal 23:2537−2553

doi: 10.1111/pbi.70045
[50]

Hafeez A, Ali S, Javed MA, Iqbal R, Khan MN, et al. 2024. Breeding for water-use efficiency in wheat: progress, challenges and prospects. Molecular Biology Reports 51:429

doi: 10.1007/s11033-024-09345-4
[51]

Zheng X, Qiao L, Liu Y, Wei N, Zhao J, et al. 2022. Genome-wide association study of grain number in common wheat from Shanxi under different water regimes. Frontiers in Plant Science 12:806295

doi: 10.3389/fpls.2021.806295
[52]

Bennani S, Birouk A, Jlibene M, Sanchez-Garcia M, Nsarellah N, et al. 2022. Drought-tolerance QTLs associated with grain yield and related traits in spring bread wheat. Plants 11(7):986

doi: 10.3390/plants11070986
[53]

Khalid MA, Ali Z, Tahir MHN, Ghaffar A, Ahmad J. 2023. Genetic effects of GA-responsive dwarfing gene Rht13 on plant height, peduncle length, internodal length and grain yield of wheat under drought stress. Genes 14(3):699

doi: 10.3390/genes14030699
[54]

Abdollahi Sisi N, Stein N, Himmelbach A, Mohammadi SA. 2022. High-density linkage mapping of agronomic trait QTLs in wheat under water deficit condition using genotyping by sequencing (GBS). Plants 11(19):2533

doi: 10.3390/plants11192533
[55]

Tarawneh RA, Szira F, Monostori I, Behrens A, Alqudah AM, et al. 2019. Genetic analysis of drought response of wheat following either chemical desiccation or the use of a rain-out shelter. Journal of Applied Genetics 60:137−146

doi: 10.1007/s13353-019-00494-y
[56]

Devate NB, Krishna H, Parmeshwarappa SKV, Manjunath KK, Chauhan D, et al. 2022. Genome-wide association mapping for component traits of drought and heat tolerance in wheat. Frontiers in Plant Science 13:943033

doi: 10.3389/fpls.2022.943033
[57]

Ma J, Li R, Wang H, Li D, Wang X, et al. 2017. Transcriptomics analyses reveal wheat responses to drought stress during reproductive stages under field conditions. Frontiers in Plant Science 8:592

doi: 10.3389/fpls.2017.00592
[58]

Kuromori T, Seo M, Shinozaki K. 2018. ABA transport and plant water stress responses. Trends in Plant Science 23:513−522

doi: 10.1016/j.tplants.2018.04.001
[59]

Zhang J, Shao W, Xu Y, Tian FA, Chen J, et al. 2025. Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation. Nature Communications 16:3947

doi: 10.1038/s41467-025-59329-6
[60]

Wang X, Lin G, Wang H, Zhang Z, Wang Y, et al. 2025. Rice B2 and B3 subgroup RAF kinases play central roles in both ABA and osmotic stress signaling. Cell Reports 44:115894

doi: 10.1016/j.celrep.2025.115894
[61]

Feng Z, Li H, Sun Z, Cheng J, Hua D, et al. 2025. ZmGCT1/2 negatively regulate drought tolerance in maize by inhibiting ZmSLAC1 to maintain guard cell turgor. Proceedings of the National Academy of Sciences of the United States of America 122:e2423037122

doi: 10.1073/pnas.2423037122
[62]

Zhang T, Zhang Y, Ding Y, Yang Y, Zhao D, et al. 2025. Research on the regulation mechanism of drought tolerance in wheat. Plant Cell Reports 44(4):77

doi: 10.1007/s00299-025-03465-2
[63]

Borràs-Gelonch G, Rebetzke GJ, Richards RA, Romagosa I. 2012. Genetic control of duration of pre-anthesis phases in wheat (Triticum aestivum L.) and relationships to leaf appearance, tillering, and dry matter accumulation. Journal of Experimental Botany 63:69−89

doi: 10.1093/jxb/err230
[64]

Ferrante A, Savin R, Slafer GA. 2013. Is floret primordia death triggered by floret development in durum wheat? Journal of Experimental Botany 64:2859−2869

doi: 10.1093/jxb/ert129
[65]

Carmo-Silva E, Andralojc PJ, Scales JC, Driever SM, Mead A, et al. 2017. Phenotyping of field-grown wheat in the UK highlights contribution of light response of photosynthesis and flag leaf longevity to grain yield. Journal of Experimental Botany 68:3473−3486

doi: 10.1093/jxb/erx169
[66]

González FG, Miralles DJ, Slafer GA. 2011. Wheat floret survival as related to pre-anthesis spike growth. Journal of Experimental Botany 62:4889−4901

doi: 10.1093/jxb/err182
[67]

Mega R, Abe F, Kim JS, Tsuboi Y, Tanaka K, et al. 2019. Tuning water-use efficiency and drought tolerance in wheat using abscisic acid receptors. Nature Plants 5:153−159

doi: 10.1038/s41477-019-0361-8
[68]

Liu Y, Yu TF, Li YT, Zheng L, Lu ZW, et al. 2022. Mitogen-activated protein kinase TaMPK3 suppresses ABA response by destabilising TaPYL4 receptor in wheat. New Phytologist 236:114−131

doi: 10.1111/nph.18326
[69]

Zhang Y, Wang J, Li Y, Zhang Z, Yang L, et al. 2023. Wheat TaSnRK2.10 phosphorylates TaERD15 and TaENO1 and confers drought tolerance when overexpressed in rice. Plant Physiology 191:1344−1364

doi: 10.1093/plphys/kiac523
[70]

Du L, Yu M, Wang Q, Ma Z, Li S, et al. 2024. The ABF transcription factor TaABF2 interacts with TaSnRK2s to ameliorate drought tolerance in wheat. Journal of Genetics and Genomics 51:1521−1524

doi: 10.1016/j.jgg.2024.09.022
[71]

Santner A, Estelle M. 2010. The ubiquitin-proteasome system regulates plant hormone signaling. The Plant Journal 61:1029−1040

doi: 10.1111/j.1365-313X.2010.04112.x
[72]

Ding S, Zhang B, Qin F. 2015. Arabidopsis RZFP34/CHYR1, a ubiquitin E3 ligase, regulates stomatal movement and drought tolerance via SnRK2.6-mediated phosphorylation. The Plant Cell 27:3228−3244

doi: 10.1105/tpc.15.00321
[73]

Liu Q, Ning Y, Zhang Y, Yu N, Zhao C, et al. 2017. OsCUL3a negatively regulates cell death and immunity by degrading OsNPR1 in rice. The Plant Cell 29:345−359

doi: 10.1105/tpc.16.00650
[74]

Yang W, Wu K, Wang B, Liu H, Guo S, et al. 2021. The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice. Molecular Plant 14:1699−1713

doi: 10.1016/j.molp.2021.06.027
[75]

Li S, Zhang Y, Liu Y, Zhang P, Wang X, et al. 2024. The E3 ligase TaGW2 mediates transcription factor TaARR12 degradation to promote drought resistance in wheat. The Plant Cell 36:605−625

doi: 10.1093/plcell/koad307
[76]

Zhang N, Yin Y, Liu X, Tong S, Xing J, et al. 2017. The E3 ligase TaSAP5 alters drought stress responses by promoting the degradation of DRIP proteins. Plant Physiology 175:1878−1892

doi: 10.3410/f.732062630.793541132
[77]

Wu X, Gong F, Cao D, Hu X, Wang W. 2016. Advances in crop proteomics: PTMs of proteins under abiotic stress. Proteomics 16:847−865

doi: 10.1002/pmic.201500301
[78]

Liu Z, Yang Q, Liu X, Li J, Zhang L, et al. 2025. Suppression of TaHDA8-mediated lysine deacetylation of TaAREB3 acts as a drought-adaptive mechanism in wheat root development. Molecular Plant 18:1222−1240

doi: 10.1016/j.molp.2025.06.012
[79]

Tardieu F. 2022. Different avenues for progress apply to drought tolerance, water use efficiency and yield in dry areas. Current Opinion in Biotechnology 73:128−134

doi: 10.1016/j.copbio.2021.07.019
[80]

Zhou Y, Wang D, Wang H, Qiao Y, Zhao P, et al. 2025. Integrative omics of the genetic basis for wheat WUE and drought resilience reveal the function of TaMYB7-A1. Nature Communications 16:8622

doi: 10.1038/s41467-025-63642-5
[81]

Zheng J, Yang Z, Madgwick PJ, Carmo-Silva E, Parry MAJ, et al. 2015. TaER expression is associated with transpiration efficiency traits and yield in bread wheat. PLoS One 10:e0128415

doi: 10.1371/journal.pone.0128415
[82]

Wang D, Zhang X, Cao Y, Batool A, Xu Y, et al. 2024. TabHLH27 orchestrates root growth and drought tolerance to enhance water use efficiency in wheat. Journal of Integrative Plant Biology 66:1295−1312

doi: 10.1111/jipb.13670
[83]

Wang M, Cheng J, Wu J, Chen J, Liu D, et al. 2024. Variation in TaSPL6-D confers salinity tolerance in bread wheat by activating TaHKT1;5-D while preserving yield-related traits. Nature Genetics 56:1257−1269

doi: 10.1038/s41588-024-01762-2
[84]

Liang X, Li J, Yang Y, Jiang C, Guo Y. 2024. Designing salt stress-resilient crops: current progress and future challenges. Journal of Integrative Plant Biology 66:303−329

doi: 10.1111/jipb.13599
[85]

Bi C, Yu Y, Dong C, Yang Y, Zhai Y, et al. 2021. The bZIP transcription factor TabZIP15 improves salt stress tolerance in wheat. Plant Biotechnology Journal 19:209−211

doi: 10.1111/pbi.13453
[86]

Qiu D, Hu W, Zhou Y, Xiao J, Hu R, et al. 2021. TaASR1-D confers abiotic stress resistance by affecting ROS accumulation and ABA signalling in transgenic wheat. Plant Biotechnology Journal 19:1588−1601

doi: 10.1111/pbi.13572
[87]

Du L, Ding L, Huang X, Tang D, Chen B, et al. 2024. Natural variation in a K+-preferring HKT transporter contributes to wheat shoot K+ accumulation and salt tolerance. Plant, Cell & Environment 47:540−556

doi: 10.1111/pce.14746
[88]

Xu H, Dong J, Meng X, Jiang H, Ding G, et al. 2025. TaHAL3-7A increases grain yield by enhancing photosynthetic pigment content in wheat (Triticum aestivum L.). The Plant Journal 122:e70274

doi: 10.1111/tpj.70274
[89]

Wang M, Yuan J, Qin L, Shi W, Xia G, et al. 2020. TaCYP81D5, one member in a wheat cytochrome P450 gene cluster, confers salinity tolerance via reactive oxygen species scavenging. Plant Biotechnology Journal 18:791−804

doi: 10.1111/pbi.13247
[90]

Yang R, Yang Z, Xing M, Jing Y, Zhang Y, et al. 2023. TaBZR1 enhances wheat salt tolerance via promoting ABA biosynthesis and ROS scavenging. Journal of Genetics and Genomics 50:861−871

doi: 10.1016/j.jgg.2023.09.006
[91]

Xiao G, Wang M, Li X, Jiang Z, Zhang H, et al. 2024. TaCHP encoding C1-domain protein stably enhances wheat yield in saline-alkaline fields. Journal of Integrative Plant Biology 66:169−171

doi: 10.1111/jipb.13605
[92]

Xiao G, Jiang Z, Xing T, Chen Y, Zhang H, et al. 2025. Small ubiquitin-like modifier protease gene TaDSU enhances salt tolerance of wheat. New Phytologist 245:2540−2552

doi: 10.1111/nph.20171
[93]

Cui M, Li Y, Li J, Yin F, Chen X, et al. 2023. Ca2+-dependent TaCCD1 cooperates with TaSAUR215 to enhance plasma membrane H+-ATPase activity and alkali stress tolerance by inhibiting PP2C-mediated dephosphorylation of TaHA2 in wheat. Molecular Plant 16:571−587

doi: 10.1016/j.molp.2023.01.010
[94]

Danquah A, de Zelicourt A, Colcombet J, Hirt H. 2014. The role of ABA and MAPK signaling pathways in plant abiotic stress responses. Biotechnology Advances 32:40−52

doi: 10.1016/j.biotechadv.2013.09.006
[95]

Kumar V, Thakur JK, Prasad M. 2021. Histone acetylation dynamics regulating plant development and stress responses. Cellular and Molecular Life Sciences 78:4467−4486

doi: 10.1007/s00018-021-03794-x
[96]

Park J, Lim CJ, Shen M, Park HJ, Cha JY, et al. 2018. Epigenetic switch from repressive to permissive chromatin in response to cold stress. Proceedings of the National Academy of Sciences of the United States of America 115:E5400−E5409

doi: 10.1073/pnas.1721241115
[97]

Liu X, Zhao Y, Zhang J, Tang G, Zhu W, et al. 2025. Wheat source-sink metabolic network dynamics during grain filling under drought-heat combined stress. Journal of Agricultural and Food Chemistry 73:7003−7018

doi: 10.1021/acs.jafc.5c00721
[98]

Shen K, Ye B, Yu X, Shen P, Yu R, et al. 2025. Dissection of genomic drivers of spike morphology changes in wheat by high-throughput phenotyping. Cell Reports 44:116120

doi: 10.1016/j.celrep.2025.116120
[99]

Wang C, Yang X, Li G. 2021. Molecular insights into inflorescence meristem specification for yield potential in cereal crops. International Journal of Molecular Sciences 22:3508

doi: 10.3390/ijms22073508
[100]

Feng N, Song G, Guan J, Chen K, Jia M, et al. 2017. Transcriptome profiling of wheat inflorescence development from spikelet initiation to floral patterning identified stage-specific regulatory genes. Plant Physiology 174:1779−1794

doi: 10.1104/pp.17.00310
[101]

Kong X, Wang F, Wang Z, Gao X, Geng S, et al. 2023. Grain yield improvement by genome editing of TaARF12 that decoupled peduncle and rachis development trajectories via differential regulation of gibberellin signalling in wheat. Plant Biotechnology Journal 21:1990−2001

doi: 10.1111/pbi.14107
[102]

Backhaus AE, Lister A, Tomkins M, Adamski NM, Simmonds J, et al. 2022. High expression of the MADS-box gene VRT2 increases the number of rudimentary basal spikelets in wheat. Plant Physiology 189:1536−1552

doi: 10.1093/plphys/kiac156
[103]

Liu Y, Chen J, Yin C, Wang Z, Wu H, et al. 2023. A high-resolution genotype – phenotype map identifies the TaSPL17 controlling grain number and size in wheat. Genome Biology 24:196

doi: 10.1186/s13059-023-03044-2
[104]

Xu X, Lin H, Zhang J, Burguener G, Paraiso F, et al. 2025. Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development. Genome Biology 26:352

doi: 10.1186/s13059-025-03811-3
[105]

Millsteed T, Kainer D, Sullivan R, Sun X, Li KL, et al. 2025. Spatial transcriptomics of developing wheat seed reveals concentric gene expression zones and subgenome biased expression of key genes. Plant Biotechnology Journal 23:5934−5949

doi: 10.1111/pbi.70351
[106]

Zhu M, Hsu CW, Peralta Ogorek LL, Taylor IW, La Cavera S, et al. 2025. Single-cell transcriptomics reveal how root tissues adapt to soil stress. Nature 642:721−729

doi: 10.1038/s41586-025-08941-z
[107]

Cui Y, Cao Q, Li Y, He M, Liu X. 2023. Advances in cis-element- and natural variation-mediated transcriptional regulation and applications in gene editing of major crops. Journal of Experimental Botany 74:5441−5457

doi: 10.1093/jxb/erad248
[108]

Yamaguchi-Shinozaki K, Shinozaki K. 2006. Transcriptional regulatory networks in cellular responses and tolerance to dehydration and cold stresses. Annual Review of Plant Biology 57:781−803

doi: 10.1146/annurev.arplant.57.032905.105444
[109]

Liu Q, Kasuga M, Sakuma Y, Abe H, Miura S, et al. 1998. Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis. The Plant Cell 10:1391−1406

doi: 10.2307/3870648
[110]

Rodríguez-Leal D, Lemmon ZH, Man J, Bartlett ME, Lippman ZB. 2017. Engineering quantitative trait variation for crop improvement by genome editing. Cell 171:470−480.e8

doi: 10.1016/j.cell.2017.08.030
[111]

Hendelman A, Zebell S, Rodriguez-Leal D, Dukler N, Robitaille G, et al. 2021. Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection. Cell 184:1724−1739.e16

doi: 10.1016/j.cell.2021.02.001
[112]

Song X, Meng X, Guo H, Cheng Q, Jing Y, et al. 2022. Targeting a gene regulatory element enhances rice grain yield by decoupling panicle number and size. Nature Biotechnology 40:1403−1411

doi: 10.1038/s41587-022-01281-7