[1]

Lin D, Du S, Zhao Z, Zhang T, Wang L, et al. 2025. Climate warming fuels the global antibiotic resistome by altering soil bacterial traits. Nature Ecology & Evolution 9(8):1512−1526

doi: 10.1038/s41559-025-02740-5
[2]

Lin D, Xu J-Y, Wang L, Du S, Zhu D. 2024. Long-term application of organic fertilizer prompting the dispersal of antibiotic resistance genes and their health risks in the soil plastisphere. Environment International 183:108431

doi: 10.1016/j.envint.2024.108431
[3]

Pärnänen K, Ruuskanen MO, Sommeria-Klein G, Laitinen V, Kantanen P, et al. 2025. Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort. Nature Communications 16:5963

doi: 10.1038/s41467-025-61137-x
[4]

Li R, Zhu L, Yang K, Li H, Zhu YG, et al. 2021. Impact of urbanization on antibiotic resistome in different microplastics: evidence from a large-scale whole river analysis. Environmental Science & Technology 55(13):8760−8770

doi: 10.1021/acs.est.1c01395
[5]

Ni N, Ding Q, Zhang T, Liu C, Guo X, et al. 2026. Fragmented microplastics synergize with biological treatment to potentiate antibiotic resistance dissemination during sewage treatment. Environmental Science & Technology 60(12):9554−9564

doi: 10.1021/acs.est.5c18221
[6]

Tian L, Zhao S, Zhang R, Lv S, Chen D, et al. 2024. Tire wear chemicals in the urban atmosphere: significant contributions of tire wear particles to PM2.5. Environmental Science & Technology 58:16952−16961

doi: 10.1021/acs.est.4c04378
[7]

Ren Y, Li W, Zhou P, Wu H, Yu L, et al. 2024. Occurrence, emission, and transport of tire and road wear particles across four environmental compartments along ring road networks in Beijing. Environmental Science & Technology 58(52):23160−23168

doi: 10.1021/acs.est.4c08466
[8]

Song W, Lin L, Oh S, Grossart HP, Yang Y. 2025. Tire wear particles in aquatic environments: From biota to ecosystem impacts. Journal of Environmental Management 388:126059

doi: 10.1016/j.jenvman.2025.126059
[9]

Khan FR, Rødland ES, Kole PJ, Van Belleghem FGAJ, Jaén-Gil A, et al. 2024. An overview of the key topics related to the study of tire particles and their chemical leachates: from problems to solutions. TrAC Trends in Analytical Chemistry 172:117563

doi: 10.1016/j.trac.2024.117563
[10]

Müller K, Hübner D, Huppertsberg S, Knepper TP, Zahn D. 2022. Probing the chemical complexity of tires: Identification of potential tire-borne water contaminants with high-resolution mass spectrometry. Science of The Total Environment 802:149799

doi: 10.1016/j.scitotenv.2021.149799
[11]

Feltracco M, Mazzi G, Barbaro E, Rosso B, Sambo F, et al. 2023. Occurrence and phase distribution of benzothiazoles in untreated highway stormwater runoff and road dust. Environmental Science and Pollution Research 30(49):107878−107886

doi: 10.1007/s11356-023-30019-4
[12]

Zhang R, Zhao S, Liu X, Tian L, Mo Y, et al. 2023. Aquatic environmental fates and risks of benzotriazoles, benzothiazoles, and p-phenylenediamines in a catchment providing water to a megacity of China. Environmental Research 216:114721

doi: 10.1016/j.envres.2022.114721
[13]

Jaeger A, Monaghan J, Tomlin H, Atkinson J, Gill CG, et al. 2024. Intensive spatiotemporal characterization of the tire wear toxin 6PPD quinone in urban waters. ACS ES&T Water 4(12):5566−5574

doi: 10.1021/acsestwater.4c00614
[14]

Geng J, Zhang W, Christie-Oleza JA, Abdolahpur Monikh F, Yang Q, et al. 2025. Succession-driven potential functional shifts in microbial communities in the tire-plastisphere: comparison of pristine and scrap tire. Environmental Pollution 385:127074

doi: 10.1016/j.envpol.2025.127074
[15]

Qin YF, Pang JY, Li Y, Liu FY, Shen LQ, et al. 2026. Tire wear particle microbiome-derived extracellular vesicles function as potent vectors amplifying antimicrobial resistance risk in soil ecosystems. Environmental Science & Technology Letters 13:684−690

doi: 10.1021/acs.estlett.6c00328
[16]

Tian Z, Zhao H, Peter KT, Gonzalez M, Wetzel J, et al. 2021. A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon. Science 371:185−189

doi: 10.1126/science.abd6951
[17]

Liu G, Bao Y, Li Y, Khan J, Xing B. 2025. A commonly used tire rubber antioxidant and its quinone derivative facilitate the conjugative transfer of plasmid-mediated antibiotic resistance genes in Escherichia coli. Environmental Science & Technology 59(47):25402−25414

doi: 10.1021/acs.est.5c10086
[18]

Jaffer YD, Monikh FA, Uli K, Grossart HP. 2024. Tire wear particles enhance horizontal gene transfer of antibiotic resistance genes in aquatic ecosystems. Environmental Research 263:120187

doi: 10.1016/j.envres.2024.120187
[19]

Ding J, Zhu D, Wang Y, Wang H, Liang A, et al. 2021. Exposure to heavy metal and antibiotic enriches antibiotic resistant genes on the tire particles in soil. Science of The Total Environment 792:148417

doi: 10.1016/j.scitotenv.2021.148417
[20]

Pu Y, Hao Y, Zeng Q, Yang Q, Yang B, et al. 2025. Effects of UV-aged tire wear particles (TWPs) on soil microorganisms: microbial community, microbial metabolism, cell defense and repair, and transmission of ARGs. Journal of Environmental Chemical Engineering 13:115624

doi: 10.1016/j.jece.2025.115624
[21]

Xu JY, Ding J, Du S, Zhu D. 2024. Tire particles and its leachates: impact on antibiotic resistance genes in coastal sediments. Journal of Hazardous Materials 465:133333

doi: 10.1016/j.jhazmat.2023.133333
[22]

Zhang Q, Jiang P, Tan C, Yu J, Wang W, et al. 2025. Similar prophage induction but divergent antibiotic resistance gene occurrence: leachates and free radicals drive differential activation mechanisms in aged tire crumb rubber. Environmental Science & Technology 59(24):11974−11984

doi: 10.1021/acs.est.4c12499
[23]

Song J, Jongmans-Hochschulz E, Mauder N, Imirzalioglu C, Wichels A, et al. 2020. The Travelling Particles: investigating microplastics as possible transport vectors for multidrug resistant E. coli in the Weser estuary (Germany). Science of The Total Environment 720:137603

doi: 10.1016/j.scitotenv.2020.137603
[24]

Zhang Z, Zhao J, Li K, Wang X, Xu H, et al. 2025. "Tire plastisphere" in aquatic ecosystems: biofilms colonizing on tire particles exhibiting a distinct community structure and assembly compared to conventional plastisphere. Journal of Hazardous Materials 483:136660

doi: 10.1016/j.jhazmat.2024.136660
[25]

Chyan JM, Senoro DB, Lin CJ, Chen PJ, Chen IM. 2013. A novel biofilm carrier for pollutant removal in a constructed wetland based on waste rubber tire chips. International Biodeterioration & Biodegradation 85:638−645

doi: 10.1016/j.ibiod.2013.04.010
[26]

Naz I, Khatoon N, Ali MI, Saroj DP, Ain-ul Batool S, et al. 2014. Appraisal of the tire derived rubber (TDR) medium for wastewater treatment under aerobic and anaerobic conditions. Journal of Chemical Technology & Biotechnology 89(4):587−596

doi: 10.1002/jctb.4161
[27]

Naz I, Rehman A, Sehar S, Perveen I, Ahmed S. 2017. Assessment of an integrated tire-derived rubber media-fixed biofilm reactor (TDR-FBR) and sand column filter (SCF) for wastewater treatment at low temperature. Desalination and Water Treatment 99:185−195

doi: 10.5004/dwt.2017.21701
[28]

Sharafat I, Saeed DK, Yasmin S, Imran A, Zafar Z, et al. 2018. Interactive effect of trivalent iron on activated sludge digestion and biofilm structure in attached growth reactor of waste tire rubber. Environmental Technology 39(2):130−143

doi: 10.1080/09593330.2017.1296894
[29]

Wang L, Luo Z, Zhen Z, Yan Y, Yan C, et al. 2020. Bacterial community colonization on tire microplastics in typical urban water environments and associated impacting factors. Environmental Pollution 265:114922

doi: 10.1016/j.envpol.2020.114922
[30]

Bludau D, Volkenandt S, Wagenhofer J, Nitsche F, Boenigk J. 2025. Tire wear particles drive size-dependent loss of freshwater bacterial biofilm diversity. Environmental Pollution 384:127004

doi: 10.1016/j.envpol.2025.127004
[31]

Deng Y, Mao C, Lin Z, Su W, Cheng C, et al. 2022. Nutrients, temperature, and oxygen mediate microbial antibiotic resistance in sea bass (Lateolabrax maculatus) ponds. Science of The Total Environment 819:153120

doi: 10.1016/j.scitotenv.2022.153120
[32]

Yan Q, Xu Y, Zhong Z, Xu Y, Lin X, et al. 2023. Insights into antibiotic resistance-related changes in microbial communities, resistome and mobilome in paddy irrigated with reclaimed wastewater. Science of The Total Environment 900:165672

doi: 10.1016/j.scitotenv.2023.165672
[33]

Li W, Mao F, Te SH, He Y, Gin KY. 2021. Impacts of Microcystis on the dissemination of the antibiotic resistome in cyanobacterial blooms. ACS ES&T Water 1(5):1263−1273

doi: 10.1021/acsestwater.1c00006
[34]

Zheng Z, Huang Y, Wang L, Tang J. 2024. Ferrihydrite regulated tire-wear microplastics biofilm for enhanced nitrogen transformation in surface water. Chemical Engineering Journal 499:156206

doi: 10.1016/j.cej.2024.156206
[35]

Budiyanto F, Ghandourah MA, Orif MI, El-Maradny AA, Shaban YA, et al. 2025. Tire wear particles and leachable compounds: occurrence and fate in the aquatic environment. Regional Studies in Marine Science 89:104291

doi: 10.1016/j.rsma.2025.104291
[36]

Du Z, Refaei A, Liu Z, Schlenk D, Gan J. 2025. Tire additives and transformation products (TATPs) in roadside soils along Southern California highways. Environmental Science & Technology 59(40):21691−21699

doi: 10.1021/acs.est.5c10556
[37]

Liu YH, Mei YX, Huang Z, Zheng XM, Huang M, et al. 2025. Hydrophilicity and material type govern the aqueous release of rubber-derived chemicals: insights from extractables and leachables of road-related materials. Environmental Science & Technology 59(39):21332−21342

doi: 10.1021/acs.est.5c09371
[38]

Capolupo M, Sørensen L, Jayasena KDR, Booth AM, Fabbri E. 2020. Chemical composition and ecotoxicity of plastic and car tire rubber leachates to aquatic organisms. Water Research 169:115270

doi: 10.1016/j.watres.2019.115270
[39]

Lv M, Meng F, Man M, Lu S, Ren S, et al. 2024. Aging increases the particulate- and leachate-induced toxicity of tire wear particles to microalgae. Water Research 256:121653

doi: 10.1016/j.watres.2024.121653
[40]

Yi L, Zhang W, Li H, Lu Y, Liu J, et al. 2024. Microbial dissimilatory iron reduction facilitates release and horizontal transfer of plasmid-borne antibiotic resistance genes adsorbed on hematite. Geochimica et Cosmochimica Acta 383:70−80

doi: 10.1016/j.gca.2024.08.005
[41]

Ekhlas D, Soro AB, Leonard FC, Manzanilla EG, Burgess CM. 2022. Examining the impact of zinc on horizontal gene transfer in Enterobacterales. Scientific Reports 12:20503

doi: 10.1038/s41598-022-23690-z
[42]

Zou H, Li J, Li J, Shangguan X, Wu T, et al. 2025. Bilateral transmission of plasmid-mediated antibiotic resistance genes under polycyclic aromatic hydrocarbons pressure. Journal of Hazardous Materials 496:139401

doi: 10.1016/j.jhazmat.2025.139401
[43]

Wang J, Wang J, Zhao Z, Chen J, Lu H, et al. 2017. PAHs accelerate the propagation of antibiotic resistance genes in coastal water microbial community. Environmental Pollution 231:1145−1152

doi: 10.1016/j.envpol.2017.07.067
[44]

Murray LM, Hayes A, Snape J, Kasprzyk-Hordern B, Gaze WH, et al. 2024. Co-selection for antibiotic resistance by environmental contaminants. npj Antimicrobials and Resistance 2:9

doi: 10.1038/s44259-024-00026-7
[45]

Gillieatt BF, Coleman NV. 2024. Unravelling the mechanisms of antibiotic and heavy metal resistance co-selection in environmental bacteria. FEMS Microbiology Reviews 48(4):fuae017

doi: 10.1093/femsre/fuae017
[46]

Yu MF, Chen L, Liu G, Liu W, Yang Y, et al. 2025. Metagenomic deciphers the mobility and bacterial hosts of antibiotic resistance genes under antibiotics and heavy metals co-selection pressures in constructed wetlands. Environmental Research 269:120921

doi: 10.1016/j.envres.2025.120921
[47]

Lin L, Sun M, Pan X, Zhang W, Yang Y, et al. 2024. Absence of synergistic effects between microplastics and copper ions on the spread of antibiotic resistance genes within aquatic bacteria at the community level. Science of The Total Environment 954:176591

doi: 10.1016/j.scitotenv.2024.176591
[48]

Wang Q, Mao D, Luo Y. 2015. Ionic liquid facilitates the conjugative transfer of antibiotic resistance genes mediated by plasmid RP4. Environmental Science & Technology 49(14):8731−8740

doi: 10.1021/acs.est.5b01129
[49]

Yang K, Jing S, Liu Y, Zhou H, Liu Y, et al. 2022. Acute toxicity of tire wear particles, leachates and toxicity identification evaluation of leachates to the marine copepod, Tigriopus japonicus. Chemosphere 297:134099

doi: 10.1016/j.chemosphere.2022.134099
[50]

Li K, Hao W, Chen Z, Ye Z. 2024. Acute inhibitory effects of tire wear particles on the removal of biological phosphorus: the critical role of aging in improving environmentally persistent free radicals. Environmental Pollution 360:124638

doi: 10.1016/j.envpol.2024.124638
[51]

Li K, Hao W, Su H, Liu C, Chen Z, et al. 2024. Ecotoxicity of three typical tire wear particles to periphytic biofilms: the potentiating role after natural water-incubation-aging. Environmental Pollution 345:123561

doi: 10.1016/j.envpol.2024.123561
[52]

Li K, Chen Z, Ye Z, Hao W. 2025. Formation and potential mechanisms of transient free radicals and environmentally persistent free radicals on the surface of typical tire wear particles: role of aging modes. Chemical Engineering Journal 525:169860

doi: 10.1016/j.cej.2025.169860
[53]

Xia W, Geng Z, Meng Z, Li Z, Lian F, et al. 2026. Photoaging-driven transformation of tire wear particles: unraveling the spatiotemporal dynamics of persistent free radicals and their phytotoxic impact. Environmental Science & Technology 60(1):996−1006

doi: 10.1021/acs.est.5c03767
[54]

Li C, He Y, Zhang Q, Zhao L, Zhou Z, et al. 2026. The unexpected role of aged microplastics in inhibiting antibiotic resistance gene spread. Water Research X 30:100464

doi: 10.1016/j.wroa.2025.100464
[55]

Zhai K, Yin K, Lin Y, Chen S, Bi Y, et al. 2025. Free radicals on aging microplastics regulated the prevalence of antibiotic resistance genes in the aquatic environment: new insight into the effect of microplastics on the spreading of biofilm resistomes. Environmental Science & Technology 59(23):11735−11744

doi: 10.1021/acs.est.4c12699