doi:10.48130/mpb-0026-0005

[1]

Wei WL, Zeng R, Gu CM, Qu Y, Huang LF. 2016. Angelica sinensis in China − a review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. Journal of Ethnopharmacology 190:116−141

doi: 10.1016/j.jep.2016.05.023

[2]

Ma JP, Guo ZB, Jin L, Li YD. 2015. Phytochemical progress made in investigations of Angelica sinensis (Oliv.) Diels. Chinese Journal of Natural Medicines 13:241−249

doi: 10.1016/S1875-5364(15)30010-8

[3]

Su KH, Su SY, Ko CY, Cheng YC, Huang SS, et al. 2021. Ethnopharmacological survey of traditional Chinese medicine pharmacy prescriptions for dysmenorrhea. Frontiers in Pharmacology 12:746777

doi: 10.3389/fphar.2021.746777

[4]

Zhang HY, Bi WG, Yu Y, Liao WB. 2012. Angelica sinensis (Oliv.) Diels in China: distribution, cultivation, utilization and variation. Genetic Resources and Crop Evolution 59:607−613

doi: 10.1007/s10722-012-9795-9

[5]

Han X, Li M, Yuan Q, Lee S, Li C, et al. 2023. Advances in molecular biological research of Angelica sinensis. Medicinal Plant Biology 2:16

doi: 10.48130/MPB-2023-0016

[6]

Liu X, Luo M, Li M, Wei J. 2022. Depicting precise temperature and duration of vernalization and inhibiting early bolting and flowering of Angelica sinensis by freezing storage. Frontiers in Plant Science 13:853444

doi: 10.3389/fpls.2022.853444

[7]

Zhao Y, Liu G, Yang F, Liang Y, Gao Q, et al. 2023. Multilayered regulation of secondary metabolism in medicinal plants. Molecular Horticulture 3:11

doi: 10.1186/s43897-023-00059-y

[8]

Xiao J, Sui X, Xu Z, Liang L, Tang W, et al. 2025. CaNAC76 enhances lignin content and cold resistance in pepper by regulating CaCAD1. International Journal of Biological Macromolecules 285:138271

doi: 10.1016/j.ijbiomac.2024.138271

[9]

Yuan DP, Yang S, Feng L, Chu J, Dong H, et al. 2023. Red-light receptor phytochrome B inhibits BZR1-NAC028-CAD8B signaling to negatively regulate rice resistance to sheath blight. Plant, Cell & Environment 46:1249−1263

doi: 10.1111/pce.14502

[10]

Bang SW, Choi S, Jin X, Jung SE, Choi JW, et al. 2022. Transcriptional activation of rice CINNAMOYL-CoA REDUCTASE 10 by OsNAC5, contributes to drought tolerance by modulating lignin accumulation in roots. Plant Biotechnology Journal 20:736−747

doi: 10.1111/pbi.13752

[11]

Qu W, Huang W, Chen C, Chen J, Zhao L, et al. 2024. AdNAC20 regulates lignin and coumarin biosynthesis in the roots of Angelica Dahurica var. formosana. International Journal of Molecular Sciences 25:7998

doi: 10.3390/ijms25147998

[12]

Han K, Zhao Y, Sun Y, Li Y. 2023. NACs, generalist in plant life. Plant Biotechnology Journal 21:2433−2457

doi: 10.1111/pbi.14161

[13]

Gao Q, Zhang J, Cao J, Xiang C, Yuan C, et al. 2024. MetaDb: a database for metabolites and their regulation in plants with an emphasis on medicinal plants. Molecular Horticulture 4:17

doi: 10.1186/s43897-024-00095-2

[14]

Xu P, Ma W, Feng H, Cai W. 2024. The NAC056 transcription factor confers freezing tolerance by positively regulating expression of CBFs and NIA1 in Arabidopsis. Plant Communications 5:100923

doi: 10.1016/j.xplc.2024.100923

[15]

Han K, Zhao Y, Liu J, Tian Y, El-Kassaby YA, et al. 2024. Genome-wide investigation and analysis of NAC transcription factor family in Populus tomentosa and expression analysis under salt stress. Plant Biology 26:764−776

doi: 10.1111/plb.13657

[16]

Qiu S, Shao C, Xu R, Luo Y, Hu Q, et al. 2025. Identification of the NAC gene family in Camellia sinensis and expression analysis of CsNAC65 under shading treatment. Beverage Plant Research 5:e024

doi: 10.48130/bpr-0025-0010

[17]

Mao H, Li S, Chen B, Jian C, Mei F, et al. 2022. Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat. Molecular Plant 15:276−292

doi: 10.1016/j.molp.2021.11.007

[18]

Kim Y, Kim B, Kang J, Bae SI, Yoon H, et al. 2025. ONAC005 enhances salt stress tolerance by promoting suberin deposition in root endodermis. The Plant Journal 123:e70469

doi: 10.1111/tpj.70469

[19]

Zhang X, Huang Y, Shi Y, Wang X, Chen W, et al. 2025. PnNAC03 from Panax notoginseng functions in positively regulating saponins and lignin biosynthesis during cell wall formation. Plant Cell Reports 44:63

doi: 10.1007/s00299-025-03452-7

[20]

Dong J, Zhao X, Song X, Wang S, Zhao X, et al. 2024. Identification of Eleutherococcus senticosus NAC transcription factors and their mechanisms in mediating DNA methylation of EsFPS, EsSS, and EsSE promoters to regulate saponin synthesis. BMC Genomics 25:536

doi: 10.1186/s12864-024-10442-8

[21]

Jiang T, Zhang Y, Zuo G, Luo T, Wang H, et al. 2024. Transcription factor PgNAC72 activates DAMMARENEDIOL SYNTHASE expression to promote ginseng saponin biosynthesis. Plant Physiology 195:2952−2969

doi: 10.1093/plphys/kiae202

[22]

Han X, Li C, Sun S, Ji J, Nie B, et al. 2022. The chromosome-level genome of female ginseng (Angelica sinensis) provides insights into molecular mechanisms and evolution of coumarin biosynthesis. The Plant Journal 112:1224−1237

doi: 10.1111/tpj.16007

[23]

Chen C, Wu Y, Li J, Wang X, Zeng Z, et al. 2023. TBtools-II: a 'one for all, all for one' bioinformatics platform for biological big-data mining. Molecular Plant 16:1733−1742

doi: 10.1016/j.molp.2023.09.010

[24]

Arshad KT, Li C, Li L, Wang J, Chen J, et al. 2025. Genome-wide identification and expression profiling of bHLH transcription factors associated with ferulic acid biosynthesis in Angelica sinensis. Frontiers in Plant Science 16:1718585

doi: 10.3389/fpls.2025.1718585

[25]

Zhang G, Jiao Y, Zhao Z, Chen Q, Wang Z, et al. 2024. Genome-wide and expression pattern analysis of the HIT4 gene family uncovers the involvement of GHHIT4_4 in response to Verticillium Wilt in Gossypium hirsutum. Genes 15:348

doi: 10.3390/genes15030348

[26]

Zhao Y, Zhang G, Tang Q, Song W, Gao Q, et al. 2022. EbMYBP1, a R2R3-MYB transcription factor, promotes flavonoid biosynthesis in Erigeron breviscapus. Frontiers in Plant Science 13:946827

doi: 10.3389/fpls.2022.946827

[27]

Arshad KT, Xiang C, Yuan C, Li L, Wang J, et al. 2024. Elucidation of AsANS controlling pigment biosynthesis in Angelica sinensis through hormonal and transcriptomic analysis. Physiologia Plantarum 176:e14500

doi: 10.1111/ppl.14500

[28]

Wang J, Zhou PH, Li CH, Liang YL, Liu GZ, et al. 2024. Progress on medicinal plant regeneration and the road ahead. Medicinal Plant Biology 3:e030

doi: 10.48130/mpb-0024-0026

[29]

Peng DQ, Luo MM, Guo XW, Li MF, Wei JH. 2024. Selection of reference genes for quantitative real-time PCR analysis in Angelica sinensis. Chinese Traditional and Herbal Drugs 55:269−278

[30]

Luan Y, Chen Z, Meng J, Tao J, Zhao D. 2023. PoWRKY17 promotes drought tolerance in Paeonia ostii by modulating lignin accumulation. Industrial Crops and Products 204:117228

doi: 10.1016/j.indcrop.2023.117228

[31]

Yuan C, Li L, Zhou P, Xiang C, Huang C, et al. 2025. Decoding the root lignification mechanism of Angelica sinensis through genome-wide DNA methylation analysis. Journal of Experimental Botany 76:2573−2589

doi: 10.1093/jxb/erae392

[32]

Chen S, Zhou Y, Chen Y, Gu J. 2018. Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34:i884−i890

doi: 10.1093/bioinformatics/bty560

[33]

Kim D, Langmead B, Salzberg SL. 2015. HISAT: a fast spliced aligner with low memory requirements. Nature Methods 12:357−360

doi: 10.1038/nmeth.3317

[34]

Wang J, Li CH, Xiang CF, Zhou PH, Li LS, et al. 2024. Establishment and application of highly efficient regeneration, genetic transformation and genome editing system for cucurbitacins biosynthesis in Hemsleya chinensis. BMC Plant Biology 24:1052

doi: 10.1186/s12870-024-05717-x

[35]

Zhang Q, Wang L, Wang Z, Zhang R, Liu P, et al. 2021. The regulation of cell wall lignification and lignin biosynthesis during pigmentation of winter jujube. Horticulture Research 8:238

doi: 10.1038/s41438-021-00670-4

[36]

Li M, Cheng C, Zhang X, Zhou S, Wang C, et al. 2019. PpNAC187 enhances lignin synthesis in 'Whangkeumbae' pear (Pyrus pyrifolia) 'Hard-End' fruit. Molecules 24:4338

doi: 10.3390/molecules24234338

[37]

Jung SE, Kim TH, Shim JS, Bang SW, Bin Yoon H, et al. 2022. Rice NAC17 transcription factor enhances drought tolerance by modulating lignin accumulation. Plant Science 323:111404

doi: 10.1016/j.plantsci.2022.111404

[38]

Sun Y, Jiang C, Jiang R, Wang F, Zhang Z, et al. 2021. A novel NAC transcription factor from Eucalyptus, EgNAC141, positively regulates lignin biosynthesis and increases lignin deposition. Frontiers in Plant Science 12:642090

doi: 10.3389/fpls.2021.642090

[39]

Duan AQ, Tao JP, Jia LL, Tan GF, Liu JX, et al. 2020. AgNAC1, a celery transcription factor, related to regulation on lignin biosynthesis and salt tolerance. Genomics 112:5254−5264

doi: 10.1016/j.ygeno.2020.09.049

[40]

Nie G, Yang Z, He J, Liu A, Chen J, et al. 2021. Genome-wide investigation of the NAC transcription factor family in Miscanthus sinensis and expression analysis under various abiotic stresses. Frontiers in Plant Science 12:766550

doi: 10.3389/fpls.2021.766550

[41]

Ma M, Hao T, Ren X, Liu C, Gela A, et al. 2025. NAC family gene CmNAC34 positively regulates fruit ripening through interaction with CmNAC-NOR in Cucumis melo. Journal of Integrative Agriculture 24:2601−2618

doi: 10.1016/j.jia.2024.11.041

[42]

Xu Y, Zou S, Zeng H, Wang W, Wang B, et al. 2022. A NAC transcription factor TuNAC69 contributes to ANK-NLR-WRKY NLR-mediated stripe rust resistance in the diploid wheat Triticum urartu. International Journal of Molecular Sciences 23:564

doi: 10.3390/ijms23010564

[43]

Li X, Wang N, She W, Guo Z, Pan H, et al. 2022. Identification and functional analysis of the CgNAC043 gene involved in lignin synthesis from Citrusgrandis 'San Hong'. Plants 11:403

doi: 10.3390/plants11030403

[44]

Cheng C, Zhang C, Jin X, Wang T, Zhang Y, et al. 2025. Calcium disrupts CML38/WRKY46-NAC187-CCR cascade to inhibit the formation of lignin-related physiological disorders in pear fruit. Plant Biotechnology Journal 23:3478−3494

doi: 10.1111/pbi.70158

[45]

Gong X, Qi K, Zhao L, Xie Z, Pan J, et al. 2024. PbAGL7–PbNAC47–PbMYB73 complex coordinately regulates PbC3H1 and PbHCT17 to promote the lignin biosynthesis in stone cells of pear fruit. The Plant Journal 120:1933−1953

doi: 10.1111/tpj.17090