doi:10.48130/abd-0026-0005

[1]

Gurib-Fakim A. 2006. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine 27(1):1−93

doi: 10.1016/j.mam.2005.07.008

[2]

Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. 2020. Worldwide research trends on medicinal plants. International Journal of Environmental Research and Public Health 17(10):3376

doi: 10.3390/ijerph17103376

[3]

Mosoh DA, Khandel AK, Verma SK, Vendram WA. 2024. Multi-explant and multiplex applications of plant growth regulators: a critical analysis of direct organogenesis in Gloriosa superba (L.). Tropical Plants 3:e039

doi: 10.48130/tp-0024-0038

[4]

Mosoh DA, Khandel AK, Verma SK, Vendrame WA. 2024. Overcoming dual seed dormancy and enhancing in vitro seedling development of Gloriosa superba (L.) with a targeted sterilization approach and plant growth regulator synergy. Tropical Plants 3:e031

doi: 10.48130/tp-0024-0033

[5]

Mosoh DA. 2024. Recent advances in phytochemical research for cancer treatment. In Recent Advances in Phytochemical Research, ed. Khan MK. London, UK: IntechOpen. doi: 10.5772/intechopen.1007200

[6]

Mosoh DA, Khandel AK, Verma SK, Vendrame WA. 2024. Standardizing in vitro callus induction and indirect organogenesis of Gloriosa superba L. leaf explants using exogenous phytohormones. Journal of Plant Biotechnology 51:237−252

doi: 10.5010/JPB.2024.51.023.237

[7]

Mirzoieva T, Heraimovych V, Humeniuk I, Tomashevska O, Cherednichenko O. 2020. Economical assessment of medicinal plants market concentration and monopolization level in Ukraine. E3S Web of Conferences 164:09025

doi: 10.1051/e3sconf/202016409025

[8]

Wallaart TE, Pras N, Beekman AC, Quax WJ. 2000. Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes. Planta Medica 66(1):57−62

doi: 10.1055/s-2000-11115

[9]

Grigorieva E, Livenets A, Stelmakh E. 2023. Adaptation of agriculture to climate change: a scoping review. Climate 11(10):202

doi: 10.3390/cli11100202

[10]

Li Y, Qin W, Liu H, Chen T, Yan X, et al. 2023. Increased artemisinin production by promoting glandular secretory trichome formation and reconstructing the artemisinin biosynthetic pathway in Artemisia annua. Horticulture Research 10(5):uhad055

doi: 10.1093/hr/uhad055

[11]

Li Y, Yang Y, Li L, Tang K, Hao X, et al. 2024. Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L. Horticulture Research 11(2):uhad292

doi: 10.1093/hr/uhad292

[12]

Mosoh DA. 2025. Plant growth regulator studies and emerging biotechnological approaches in Artemisia annua L.: a comprehensive overview. South African Journal of Botany 181:181−222

doi: 10.1016/j.sajb.2025.04.016

[13]

Shen Q, Yan T, Fu X, Tang K. 2016. Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L. Science Bulletin 61(1):18−25

doi: 10.1007/s11434-015-0983-9

[14]

Hassani D, Fu X, Shen Q, Khalid M, Rose JKC, et al. 2020. Parallel transcriptional regulation of artemisinin and flavonoid biosynthesis. Trends in Plant Science 25(5):466−476

doi: 10.1016/j.tplants.2020.01.001

[15]

Qamar F, Mishra A, Ashrafi K, Saifi M, Dash PK, et al. 2024. Increased artemisinin production in Artemisia annua L. by co-overexpression of six key biosynthetic enzymes. International Journal of Biological Macromolecules 281:136291

doi: 10.1016/j.ijbiomac.2024.136291

[16]

Tang Y, Xiang L, Zhang F, Tang K, Liao Z. 2023. Metabolic regulation and engineering of artemisinin biosynthesis in Artemisia annua. Medicinal Plant Biology 2:4

doi: 10.48130/MPB-2023-0004

[17]

Pulice G, Pelaz S, Matías-Hernández L. 2016. Molecular farming in Artemisia annua, a promising approach to improve anti-malarial drug production. Frontiers in Plant Science 7:329

doi: 10.3389/fpls.2016.00329

[18]

Tu Y. 2011. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature Medicine 17(10):1217−1220

doi: 10.1038/nm.2471

[19]

Antoine T, Fisher N, Amewu R, O'Neill PM, Ward SA, et al. 2014. Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. Journal of Antimicrobial Chemotherapy 69(4):1005−1016

doi: 10.1093/jac/dkt486

[20]

Eastman RT, Fidock DA. 2009. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nature Reviews Microbiology 7(12):864−874

doi: 10.1038/nrmicro2239

[21]

Lyu HN, Ma N, Meng Y, Zhang X, Wong YK, et al. 2021. Study towards improving artemisinin-based combination therapies. Natural Product Reports 38(7):1243−1250

doi: 10.1039/D0NP00079E

[22]

World Health Organization. 2024. Global malaria programme operational strategy 2024–2030. Geneva, Switzerland: World Health Organization. www.who.int/publications/i/item/9789240090149

[23]

Altieri MA, Nicholls CI, Henao A, Lana MA. 2015. Agroecology and the design of climate change-resilient farming systems. Agronomy for Sustainable Development 35(3):869−890

doi: 10.1007/s13593-015-0285-2

[24]

Langridge P, Braun H, Hulke B, Ober E, Prasanna BM. 2021. Breeding crops for climate resilience. Theoretical and Applied Genetics 134(6):1607−1611

doi: 10.1007/s00122-021-03854-7

[25]

Delabays N, Simonnet X, Gaudin M. 2001. The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars. Current Medicinal Chemistry 8(15):1795−1801

doi: 10.2174/0929867013371635

[26]

Soni R, Shankar G, Mukhopadhyay P, Gupta V. 2022. A concise review on Artemisia annua L.: a major source of diverse medicinal compounds. Industrial Crops and Products 184:115072

doi: 10.1016/j.indcrop.2022.115072

[27]

Weathers PJ. 2023. Artemisinin as a therapeutic vs. its more complex Artemisia source material. Natural Product Reports 40(7):1158−1169

doi: 10.1039/D2NP00072E

[28]

Ferreira JFS, Janick J. 1995. Floral morphology of Artemisia annua with special reference to trichomes. International Journal of Plant Sciences 156(6):807−815

doi: 10.1086/297304

[29]

Weston LA, Duke SO. 2003. Weed and crop allelopathy. Critical Reviews in Plant Sciences 22(3-4):367−389

doi: 10.1080/713610861

[30]

Li L, Josef BA, Liu B, Zheng S, Huang L, et al. 2017. Three-dimensional evaluation on ecotypic diversity of traditional Chinese medicine: a case study of Artemisia annua L. Frontiers in Plant Science 8:1225

doi: 10.3389/fpls.2017.01225

[31]

Unitaid. 2022. Global malaria diagnostic and artemisinin treatment commodities demand forecast (phase 2). Unitaid, Geneva, Switzerland. https://unitaid.org/uploads/Global_malaria_diagnostic_and_artemisinin_treatment_commodities_demand_forecast_policy_brief-1.pdf

[32]

Scarcella M, Grassi F, Mastrorilli M. 2011. Artemisia annua L.: agro-techniques for semi-arid environments. Italian Journal of Agronomy 6(3):e26

doi: 10.4081/ija.2011.e26

[33]

Marchese JA, Ferreira JFS, Rehder VLG, Rodrigues O. 2010. Water deficit effect on the accumulation of biomass and artemisinin in annual wormwood (Artemisia annua L., Asteraceae). Brazilian Journal of Plant Physiology 22:1−9

doi: 10.1590/s1677-04202010000100001

[34]

Marchese JA, Ferreira JFS, Moraes RM, Dayan FE, Rodrigues MFF, et al. 2023. Crop phenology and floral induction in different Artemisia annua L. genotypes. Industrial Crops and Products 192:116118

doi: 10.1016/j.indcrop.2022.116118

[35]

Ellman A. 2010. Cultivation of Artemisia annua in Africa and Asia. Outlooks on Pest Management 21(2):84−88

doi: 10.1564/21apr08

[36]

Simonnet X, Quennoz M, Jacquemettaz P, Piantini U, Carlen C. 2009. Incidence of the phenological stage on the yield and quality of floral stems of white genepi (Artemisia umbelliformis Lam.). Acta Horticulturae 826:31−34

doi: 10.17660/actahortic.2009.826.3

[37]

Weathers PJ. 2025. Medicinal plants as more sustainable therapeutic solutions: Artemisia annua and Artemisia afra as case studies. Global Health Economics and Sustainability 3(3):1−17

doi: 10.36922/ghes.4927

[38]

Stringer LC, Fraser EDG, Harris D, Lyon C, Pereira L, et al. 2020. Adaptation and development pathways for different types of farmers. Environmental Science & Policy 104:174−189

doi: 10.1016/j.envsci.2019.10.007

[39]

Ferreira JFS, Laughlin JC, Delabays N, de Magalhães PM. 2005. Cultivation and genetics of Artemisia annua L. for increased production of the antimalarial artemisinin. Plant Genetic Resources 3(2):206−229

doi: 10.1079/pgr200585

[40]

Jelodar NB, Bhatt A, Mohamed K, Keng CL. 2014. New cultivation approaches of Artemisia annua L. for a sustainable production of the antimalarial drug artemisinin. Journal of Medicinal Plants Research 8(10):441−447

doi: 10.5897/jmpr11.1053

[41]

Javaid M, Haleem A, Khan IH, Suman R. 2023. Understanding the potential applications of artificial intelligence in agriculture sector. Advanced Agrochem 2(1):15−30

doi: 10.1016/j.aac.2022.10.001

[42]

Graham IA, Besser K, Blumer S, Branigan CA, Czechowski T, et al. 2010. The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin. Science 327(5963):328−331

doi: 10.1126/science.1182612

[43]

Li D, Song J, Tang Y, Zhang Z, Yang C, et al. 2025. AaMYB121, a novel R2-MYB-like transcription factor, regulates artemisinin biosynthesis in Artemisia annua. International Journal of Molecular Sciences 26(6):2441

doi: 10.3390/ijms26062441

[44]

Ayoobi A, Saboora A, Asgarani E, Efferth T. 2024. Iron oxide nanoparticles (Fe₃O₄-NPs) elicited Artemisia annua L. in vitro toward enhancing artemisinin production through overexpression of key genes in the terpenoids biosynthetic pathway and induction of oxidative stress. Plant Cell, Tissue and Organ Culture (PCTOC) 156(3):85

doi: 10.1007/s11240-024-02705-9

[45]

Cao J, Chen Z, Wang L, Yan N, Lin J, et al. 2024. Graphene enhances artemisinin production in the traditional medicinal plant Artemisia annua via dynamic physiological processes and miRNA regulation. Plant Communications 5(3):100742

doi: 10.1016/j.xplc.2023.100742

[46]

Shu G, Tang Y, Yuan M, Wei N, Zhang F, et al. 2022. Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua. Acta Pharmaceutica Sinica B 12(3):1500−1513

doi: 10.1016/j.apsb.2021.09.026

[47]

Ghatas Y, Ali M, Elsadek M, Mohamed Y. 2021. Enhancing growth, productivity and artemisinin content of Artemisia annua L. plant using seaweed extract and micronutrients. Industrial Crops and Products 161:113202

doi: 10.1016/j.indcrop.2020.113202

[48]

Wani KI, Choudhary S, Zehra A, Naeem M, Weathers P, et al. 2021. Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches. Planta 254(2):29

doi: 10.1007/s00425-021-03676-3

[49]

Wani KI, Zehra A, Choudhary S, Naeem M, Khan MMA, et al. 2023. Exogenous strigolactone (GR24) positively regulates growth, photosynthesis, and improves glandular trichome attributes for enhanced artemisinin production in Artemisia annua. Journal of Plant Growth Regulation 42(8):4606−4615

doi: 10.1007/s00344-022-10654-w

[50]

Zhai T, Wang Y, Liu C, Liu Z, Zhao M, et al. 2019. Trichoderma asperellum ACCC30536 inoculation improves soil nutrition and leaf artemisinin production in Artemisia annua. Acta Physiologiae Plantarum 41(4):46

doi: 10.1007/s11738-019-2836-7

[51]

Zheng LP, Li XP, Zhou LL, Wang JW. 2021. Endophytes in Artemisia annua L.: new potential regulators for plant growth and artemisinin biosynthesis. Plant Growth Regulation 95(3):293−313

doi: 10.1007/s10725-021-00751-3

[52]

Dietrich JA, Yoshikuni Y, Fisher KJ, Woolard FX, Ockey D, et al. 2009. A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450_BM3. ACS Chemical Biology 4(4):261−267

doi: 10.1021/cb900006h

[53]

Martin VJJ, Pitera DJ, Withers ST, Newman JD, Keasling JD. 2003. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nature Biotechnology 21(7):796−802

doi: 10.1038/nbt833

[54]

Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, et al. 2013. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496(7446):528−532

doi: 10.1038/nature12051

[55]

Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, et al. 2006. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440(7086):940−943

doi: 10.1038/nature04640

[56]

Tsuruta H, Paddon CJ, Eng D, Lenihan JR, Horning T, et al. 2009. High-level production of amorpha-4, 11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PLoS One 4(2):e4489

doi: 10.1371/journal.pone.0004489

[57]

Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, et al. 2012. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proceedings of the National Academy of Sciences of the United States of America 109(3):E111−E118

doi: 10.1073/pnas.1110740109

[58]

Malhotra K, Subramaniyan M, Rawat K, Kalamuddin M, Qureshi MI, et al. 2016. Compartmentalized metabolic engineering for artemisinin biosynthesis and effective malaria treatment by oral delivery of plant cells. Molecular Plant 9(11):1464−1477

doi: 10.1016/j.molp.2016.09.013

[59]

Polito F, Denora M, Casiello D, Casiero P, Cardone L, et al. 2025. Effect of plant density on Artemisia annua L. biomass and essential oil yield and its weed seed germination suppression. Agriculture 15(13):1330

doi: 10.3390/agriculture15131330

[60]

Siswanto U, Subositi D, Isnawati A, Widiyastuti Y. 2025. Yield and artemisinin content of six polyploid accessions of Artemisia annua grown at medium altitude in Indonesia. International Journal of Agricultural Technology 21(2):673−684

doi: 10.63369/ijat.2025.21.2.673-684

[61]

Anyinkeng N, Bechem EET, Bizama FM. 2023. Evaluation of the artemisinin content of Artemisia annua L. grown in different agro-ecological zones of Cameroon. World Journal of Advanced Research and Reviews 20(1):681−689

doi: 10.30574/wjarr.2023.20.1.2037

[62]

Nyoni J, Madanzi T, Midzi J, Muziri T, Kapenzi A. 2020. Response of sweet wormwood (Artemisia annua L. ) to different rates of inorganic nitrogen fertilizer in semi-arid Zimbabwe. American Journal of Plant Sciences 11(4):529−537

doi: 10.4236/ajps.2020.114037

[63]

Das M, Rana VS, Abirami K. 2017. Seed germination and seedling growth of Artemisia annua L. Medicinal Plants − International Journal of Phytomedicines and Related Industries 9(1):29−35

doi: 10.5958/0975-6892.2017.00004.1

[64]

Bilkova I, Kjaer A, van der Kooy F, Lommen WJM. 2016. Effects of N fertilization on trichome density, leaf size and artemisinin production in Artemisia annua leaves. Acta Horticulturae 1125:369−375

doi: 10.17660/ActaHortic.2016.1125.48

[65]

Brisibe EA, Udensi O, Chukwurah PN, de Magalhäes PM, Figueira GM, et al. 2012. Adaptation and agronomic performance of Artemisia annua L. under lowland humid tropical conditions. Industrial Crops and Products 39:190−197

doi: 10.1016/j.indcrop.2012.02.018

[66]

Davies MJ, Atkinson CJ, Burns C, Woolley JG, Hipps NA, et al. 2009. Enhancement of artemisinin concentration and yield in response to optimization of nitrogen and potassium supply to Artemisia annua. Annals of Botany 104(2):315−323

doi: 10.1093/aob/mcp126

[67]

Basu A, Narayan A. 2025. The role of machine learning in transforming agricultural practices: insights into crop yield optimization and disease detection. Iran Journal of Computer Science. 8(4):1199−1217

doi: 10.1007/s42044-025-00280-6

[68]

Mishra H, Supriya, Dwivedi S. 2025. Remote sensing for sustainable agriculture: a machine learning approach to optimizing farm yield and economic returns. In Artificial Intelligence and Computer Vision for Ecological Informatics, eds. Chouhan SS, Singh UP, Saxena A, Tiwari A, Jain S. Boca Raton, FL: CRC Press. doi: 10.1201/9781003518778-7

[69]

Adinarayana S, Raju MG, Srirangam DP, Prasad DS, Kumar MR, et al. 2024. Enhancing resource management in precision farming through AI-based irrigation optimization. In How Machine Learning is Innovating Today's World: A Concise Technical Guide, eds. Dey A, Nayak S, Kumar R, Mohanty SN. USA: Wiley. pp. 221–251 doi: 10.1002/9781394214167.ch15

[70]

Sharma K, Shivandu SK. 2024. Integrating artificial intelligence and internet of things (IoT) for enhanced crop monitoring and management in precision agriculture. Sensors International 5:100292

doi: 10.1016/j.sintl.2024.100292

[71]

Fuentes-Peñailillo F, Gutter K, Vega R, Silva GC. 2024. Transformative technologies in digital agriculture: leveraging internet of things, remote sensing, and artificial intelligence for smart crop management. Journal of Sensor and Actuator Networks 13(4):39

doi: 10.3390/jsan13040039

[72]

Wang J, Wang Y, Li G, Qi Z. 2024. Integration of remote sensing and machine learning for precision agriculture: a comprehensive perspective on applications. Agronomy 14(9):1975

doi: 10.3390/agronomy14091975

[73]

Maghdid S, Askar S, Khoshaba FS, Hamad S. 2024. Deep learning algorithms for IoT based crop yield optimization. Indonesian Journal of Computer Science 13(2):2418−2425

doi: 10.33022/ijcs.v13i2.3846

[74]

Alahmad T, Neményi M, Nyéki A. 2023. Applying IoT sensors and big data to improve precision crop production: a review. Agronomy 13(10):2603

doi: 10.3390/agronomy13102603

[75]

Ali A, Hussain T, Tantashutikun N, Hussain N, Cocetta G. 2023. Application of smart techniques, internet of things and data mining for resource use efficient and sustainable crop production. Agriculture 13(2):397

doi: 10.3390/agriculture13020397

[76]

Balanay RM, Guinancias AR. 2025. Streamlining a short supply chain for increased agricultural resilience and global market opportunities: the case of lemongrass (Cymbopogon citratus) in Caraga region, Philippines. Agricultural and Food Economics 13(1):41

doi: 10.1186/s40100-025-00385-3

[77]

Ngansop MT, Forbi Funwi P, Tchoupou MCV, Zekeng JC, Djomo Chimi C, et al. 2024. Assessment of Garcinia kola Heckl value chain and its contribution to the livelihoods of local populations in eastern Cameroon. Heliyon 10(21):e39568

doi: 10.1016/j.heliyon.2024.e39568

[78]

Lokko Y, Heijde M, Schebesta K, Scholtès P, Van Montagu M, et al. 2018. Biotechnology and the bioeconomy − towards inclusive and sustainable industrial development. New Biotechnology 40:5−10

doi: 10.1016/j.nbt.2017.06.005

[79]

Kazaz B, Webster S, Yadav P. 2016. Interventions for an artemisinin-based malaria medicine supply chain. Production and Operations Management 25(9):1576−1600

doi: 10.1111/poms.12574

[80]

Shretta R, Yadav P. 2012. Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up. Malaria Journal 11(1):399

doi: 10.1186/1475-2875-11-399

[81]

Asamoah D, Abor P, Opare M. 2011. An examination of pharmaceutical supply chain for artemisinin-based combination therapies in Ghana. Management Research Review 34(7):790−809

doi: 10.1108/01409171111146689

[82]

Consultative Group on International Agricultural Research (CGIAR). 2024. Balancing food security with environmental sustainability: CGIAR approach to nutrient management, food security, and environmental sustainability. (Accessed on May 19, 2026)

[83]

Gibbon D. 2012. Save and grow: a policymaker's guide to the sustainable intensification of smallholder crop production. Experimental Agriculture 48(1):154

doi: 10.1017/S0014479711001049

[84]

Milliken W. 1997. Traditional anti-malarial medicine in Roraima, Brazil. Economic Botany 51(3):212−237

doi: 10.1007/BF02862091

[85]

Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. 2000. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. Journal of Ethnopharmacology 73(3):487−493

doi: 10.1016/s0378-8741(00)00289-0

[86]

Al-Khayri JM, Sudheer WN, Lakshmaiah VV, Mukherjee E, Nizam A, et al. 2022. Biotechnological approaches for production of artemisinin, an anti-malarial drug from Artemisia annua L. Molecules 27(9):3040

doi: 10.3390/molecules27093040

[87]

Li Q, Yuan L, Huang J. 2014. Allelopathic effects of artemisinin on ectomycorrhizal fungal isolates in vitro. Pedobiologia 57(4–6):271−276

doi: 10.1016/j.pedobi.2014.07.002

[88]

Bai Z, Huang Y, Huang J. 2013. Allelopathic effects of artemisinin on seed germination and seedling growth of vegetables. Acta Ecologica Sinica 33(23):7576−7582

doi: 10.5846/stxb201208221188

[89]

Vollmann J, Škrabišová M. 2023. Going north: adaptation of soybean to long-day environments. Journal of Experimental Botany 74(10):2933−2936

doi: 10.1093/jxb/erad105

[90]

Czechowski T, Larson TR, Catania TM, Harvey D, Wei C, et al. 2018. Detailed phytochemical analysis of high- and low artemisinin-producing chemotypes of Artemisia annua. Frontiers in Plant Science 9:641

doi: 10.3389/fpls.2018.00641

[91]

Wang X, Zhou P, Huang R, Zhang J, Ouyang X. 2021. A daylength recognition model of photoperiodic flowering. Frontiers in Plant Science 12:778515

doi: 10.3389/fpls.2021.778515

[92]

Wang X, Huang H, Lu M, Cui Y, Huang R, et al. 2023. Expanding crop adaptability to increase planting area: a promising strategy for enhancing agricultural production. Seed Biology 2:20

doi: 10.48130/seedbio-2023-0020

[93]

Qiu L, Zhou P, Wang H, Zhang C, Du C, et al. 2023. Photoperiod genes contribute to daylength-sensing and breeding in rice. Plants 12(4):899

doi: 10.3390/plants12040899

[94]

Wang X, Han J, Li R, Qiu L, Zhang C, et al. 2023. Gradual daylength sensing coupled with optimum cropping modes enhances multi-latitude adaptation of rice and maize. Plant Communications 4(1):100433

doi: 10.1016/j.xplc.2022.100433

[95]

Waha K, Dietrich JP, Portmann FT, Siebert S, Thornton PK, et al. 2020. Multiple cropping systems of the world and the potential for increasing cropping intensity. Global Environmental Change 64:102131

doi: 10.1016/j.gloenvcha.2020.102131

[96]

Kumar S, Gupta SK, Singh P, Bajpai P, Gupta MM, et al. 2004. High yields of artemisinin by multi-harvest of Artemisia annua crops. Industrial Crops and Products 19(1):77−90

doi: 10.1016/j.indcrop.2003.07.003

[97]

de Magalhães PM, Pereira B, Sartoratto A, de Oliveira J, Debrunner N. 1999. New hybrid lines of the antimalarial species Artemisia annua L. Acta Horticulturae 502:377−382

doi: 10.17660/actahortic.1999.502.62

[98]

Hackfort S. 2021. Patterns of inequalities in digital agriculture: a systematic literature review. Sustainability 13(22):12345

doi: 10.3390/su132212345

[99]

Lyu Z, Jing Z, Yang X. 2025. Bridging the digital divide for sustainable agriculture: how digital adoption strengthens farmer livelihood resilience. Frontiers in Sustainable Food Systems 9:1628588

doi: 10.3389/fsufs.2025.1628588

[100]

Xie L, Luo B, Zhong W. 2021. How are smallholder farmers involved in digital agriculture in developing countries: a case study from China. Land 10(3):245

doi: 10.3390/land10030245

[101]

Choruma D, Dirwai TL, Mutenje MJ, Mustafa M, Chimonyo VGP, et al. 2024. Digitalisation in agriculture: a scoping review of technologies in practice, challenges, and opportunities for smallholder farmers in sub-Saharan Africa. Journal of Agriculture and Food Research 18:101286

doi: 10.1016/j.jafr.2024.101286

[102]

Ngulube P. 2025. Leveraging information and communication technologies for sustainable agriculture and environmental protection among smallholder farmers in tropical Africa. Discover Environment 3(1):9

doi: 10.1007/s44274-025-00190-1

[103]

Abdulai AR, Tetteh Quarshie P, Duncan E, Fraser E. 2023. Is agricultural digitization a reality among smallholder farmers in Africa? Unpacking farmers' lived realities of engagement with digital tools and services in rural Northern Ghana. Agriculture & Food Security 12(1):11

doi: 10.1186/s40066-023-00416-6

[104]

Asenso-Okyere K, Mekonnen DA. 2012. The importance of ICTs in the provision of information for improving agricultural productivity and rural incomes in Africa. United Nations Development Programme, USA https://files.acquia.undp.org/public/migration/africa/ICT-Productivity.pdf

[105]

Kos D, Kloppenburg S. 2019. Digital technologies, hyper-transparency and smallholder farmer inclusion in global value chains. Current Opinion in Environmental Sustainability 41:56−63

doi: 10.1016/j.cosust.2019.10.011

[106]

McCarthy C, Nyoni Y, Kachamba DJ, Banda LB, Moyo B, et al. 2023. Can drones help smallholder farmers improve agriculture efficiencies and reduce food insecurity in Sub-Saharan Africa? Local perceptions from Malawi. Agriculture 13(5):1075

doi: 10.3390/agriculture13051075

[107]

Agyekumhene C, de Vries JR, van Paassen A, Macnaghten P, Schut M, et al. 2018. Digital platforms for smallholder credit access: the mediation of trust for cooperation in maize value chain financing. NJAS – Wageningen Journal of Life Sciences 86–87:77−88

doi: 10.1016/j.njas.2018.06.001

[108]

Gumbi N, Gumbi L, Twinomurinzi H. 2023. Towards sustainable digital agriculture for smallholder farmers: a systematic literature review. Sustainability 15(16):12530

doi: 10.3390/su151612530

[109]

Kaur S, Bedi M, Singh S, Kour N, Bhatti SS, et al. 2024. Monoculture of crops: a challenge in attaining food security. In Advances in Food Security and Sustainability, eds. Sharma A, Kumar M, Sharma P. Amsterdam: Elsevier. pp. 197–213 doi: 10.1016/bs.af2s.2024.07.008

[110]

Mirzaei M, Holl D, Ben Hassine M, Borgatti D, Radicetti E, et al. 2025. Soil health and nitrogen dynamics as affected by organic amendments in monocropping and intercropping of maize and mung bean systems. Soil Use and Management 41(3):e70122

doi: 10.1111/sum.70122

[111]

Yu T, Hou X, Fang X, Razavi B, Zang H, et al. 2024. Short-term continuous monocropping reduces peanut yield mainly via altering soil enzyme activity and fungal community. Environmental Research 245:117977

doi: 10.1016/j.envres.2023.117977

[112]

Udawatta RP, Rankoth L, Jose S. 2019. Agroforestry and biodiversity. Sustainability 11(10):2879

doi: 10.3390/su11102879

[113]

Pandian K, Abu Firnass Mustaffa MR, Mahalingam G, Paramasivam A, John Prince A, et al. 2024. Synergistic conservation approaches for nurturing soil, food security and human health towards sustainable development goals. Journal of Hazardous Materials Advances 16:100479

doi: 10.1016/j.hazadv.2024.100479

[114]

Shrivastava G, Rogers M, Wszelaki A, Panthee DR, Chen F. 2010. Plant volatiles-based insect pest management in organic farming. Critical Reviews in Plant Sciences 29(2):123−133

doi: 10.1080/07352681003617483

[115]

Li Q, Yang SP, Cui GL, Huang JG, Li LY, et al. 2017. Microbial biomass, enzyme activity and composition of the fungal community in rhizospheric soil cropped with Artemisia annua for several years. Acta Prataculturae Sinica 26(1):34−42

doi: 10.11686/cyxb2016091

[116]

Liu H, Huang J, Yuan L. 2018. In vitro effect of artemisinin on microbial biomasses, enzyme activities and composition of bacterial community. Applied Soil Ecology 124:1−6

doi: 10.1016/j.apsoil.2017.10.022

[117]

Jessing KK, Cedergreen N, Jensen J, Hansen HCB. 2009. Degradation and ecotoxicity of the biomedical drug artemisinin in soil. Environmental Toxicology and Chemistry 28(4):701−710

doi: 10.1897/08-153R.1

[118]

Mosoh DA, Vendrame WA. 2025. Engineered elicitation in Artemisia annua L. callus cultures alters artemisinin biosynthesis, antioxidant responses, and bioactivity. npj Science of Plants 1(1):10

doi: 10.1038/s44383-025-00009-1

[119]

Crews TE, Carton W, Olsson L. 2018. Is the future of agriculture perennial? Imperatives and opportunities to reinvent agriculture by shifting from annual monocultures to perennial polycultures. Global Sustainability 1:e11

doi: 10.1017/sus.2018.11

[120]

Lenardis AE, Morvillo CM, Gil A, de la Fuente EB. 2011. Arthropod communities related to different mixtures of oil (Glycine max L. Merr.) and essential oil (Artemisia annua L.) crops. Industrial Crops and Products 34(2):1340−1347

doi: 10.1016/j.indcrop.2010.12.001

[121]

Misra P, Maji D, Awasthi A, Pandey SS, Yadav A, et al. 2019. Vulnerability of soil microbiome to monocropping of medicinal and aromatic plants and its restoration through intercropping and organic amendments. Frontiers in Microbiology 10:2604

doi: 10.3389/fmicb.2019.02604

[122]

Limenie AD. 2025. Advancement of genetic engineering applications for enhancing legume crop improvement in agriculture. Cogent Food & Agriculture 11:2446652

doi: 10.1080/23311932.2024.2446652

[123]

Civáň P, Fricano A, Russell J, Pont C, Özkan H, et al. 2024. Genetic erosion in domesticated barley and a hypothesis of a North African centre of diversity. Ecology and Evolution 14(8):e70068

doi: 10.1002/ece3.70068

[124]

Fan PZ, Zhu GF, Wambulwa MC, Milne RI, Wu ZY, et al. 2026. Genetic origins and climate-induced erosion in economically important Asian walnuts. Conservation Biology 40:e70125

doi: 10.1111/cobi.70125

[125]

Kumari A, Sharma L, Yadav Y, Karma A, Singh J, et al. 2025. Biotechnological strategies for seed germplasm maintenance and plant genetic resource conservation. In Advances in Seed Quality Evaluation and Improvement, eds. Roy B, Shukla G, Dunna V, Sharma P, Shukla PS. Singapore: Springer Nature. pp. 379–403 doi 10.1007/978-981-96-5178-8_15

[126]

King KC, Lively CM. 2012. Does genetic diversity limit disease spread in natural host populations? Heredity 109(4):199−203

doi: 10.1038/hdy.2012.33

[127]

Mihrete TB, Mihretu FB. 2025. Crop diversification for ensuring sustainable agriculture, risk management and food security. Global Challenges 9(2):2400267

doi: 10.1002/gch2.202400267

[128]

Khoury CK, Brush S, Costich DE, Curry HA, de Haan S, et al. 2022. Crop genetic erosion: understanding and responding to loss of crop diversity. New Phytologist 233(1):84−118

doi: 10.1111/nph.17733

[129]

Fantini A, Samoggia A, Bonfigli L, Quiñones-Ruiz XF. 2025. Fairness in coffee value chains: organizational solutions for the self-governance of small producers. Frontiers in Sustainable Food Systems 9:1661027

doi: 10.3389/fsufs.2025.1661027

[130]

Garwe EC, Arpaci S, Moss AJ, Bailey K, Suchith A, et al. 2025. Ethical crossroads in agricultural data: perspectives on trust, equity and sustainability. Outlook on Agriculture 54(4):323−331

doi: 10.1177/00307270251391436

[131]

Marion P, Lwamba E, Floridi A, Pande S, Bhattacharyya M, et al. 2024. The effects of agricultural output market access interventions on agricultural, socio-economic, food security, and nutrition outcomes in low- and middle-income countries: a systematic review. Campbell Systematic Reviews 20(2):e1411

doi: 10.1002/cl2.1411

[132]

Bennett EA, Grabs J. 2025. How can sustainable business models distribute value more equitably in global value chains? Introducing 'value chain profit sharing' as an emerging alternative to fair trade, direct trade, or solidarity trade. Business Ethics, the Environment & Responsibility 34(2):581−601

doi: 10.1111/beer.12666

[133]

Jennings S, Sahan E, Maitland A. 2018. Fair value: case studies of business structures for a more equitable distribution of value in food supply chains. Oxfam, Oxford. doi: 10.21201/2017.2234

[134]

Hernandez-Martinez N, Mutlu N, Fransoo JC. 2021. Social equity in supplier–buyer relationships in smallholder agri-food supply chains. Flexible Services and Manufacturing Journal 33(4):1027−1089

doi: 10.1007/s10696-020-09397-1

[135]

Christian M, Obi A, Zantsi S, Mdoda L, Jiba P. 2024. The role of cooperatives in improving smallholder participation in agri-food value chains: a case study of one local municipality in eastern cape, South Africa. Sustainability 16(6):2241

doi: 10.3390/su16062241

[136]

Ma M, Sexton RJ. 2021. Modern agricultural value chains and the future of smallholder farming systems. Agricultural Economics 52(4):591−606

doi: 10.1111/agec.12637