[1]

Malik SC, Sozmen EG, Baeza-Raja B, Le Moan N, Akassoglou K, et al. 2021. In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. Trends in Pharmacological Sciences 42:772−788

doi: 10.1016/j.tips.2021.06.006
[2]

Mirzahosseini G, Adam JM, Nasoohi S, El-Remessy AB, Ishrat T. 2023. Lost in translation: neurotrophins biology and function in the neurovascular unit. The Neuroscientist 29:694−714

doi: 10.1177/10738584221104982
[3]

Garcia TB, Hollborn M, Bringmann A. 2017. Expression and signaling of NGF in the healthy and injured retina. Cytokine & Growth Factor Reviews 34:43−57

doi: 10.1016/j.cytogfr.2016.11.005
[4]

Lebrun-Julien F, Bertrand MJ, De Backer O, Stellwagen D, Morales CR, et al. 2010. ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proceedings of the National Academy of Sciences of the United States of America 107:3817−3822

doi: 10.1073/pnas.0909276107
[5]

Barcelona PF, Sitaras N, Galan A, Esquiva G, Jmaeff S, et al. 2016. p75NTR and its ligand ProNGF activate paracrine mechanisms etiological to the vascular, inflammatory, and neurodegenerative pathologies of diabetic retinopathy. The Journal of Neuroscience 36:8826−8841

doi: 10.1523/jneurosci.4278-15.2016
[6]

Mesentier-Louro LA, De Nicolò S, Rosso P, De Vitis LA, Castoldi V, et al. 2017. Time-dependent nerve growth factor signaling changes in the rat retina during optic nerve crush-induced degeneration of retinal ganglion cells. International Journal of Molecular Sciences 18:98

doi: 10.3390/ijms18010098
[7]

Lebrun-Julien F, Morquette B, Douillette A, Saragovi HU, Di Polo A. 2009. Inhibition of p75NTR in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Molecular and Cellular Neurosciences 40:410−420

doi: 10.1016/j.mcn.2008.12.005
[8]

Bai Y, Dergham P, Nedev H, Xu J, Galan A, et al. 2010. Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism. Journal of Biological Chemistry 285:39392−39400

doi: 10.1074/jbc.M110.147801
[9]

Fujita Y, Takashima R, Endo S, Takai T, Yamashita T. 2011. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death & Disease 2:e198−e198

doi: 10.1038/cddis.2011.85
[10]

Shi Z, Birman E, Saragovi HU. 2007. Neurotrophic rationale in glaucoma: a TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo. Developmental Neurobiology 67:884−894

doi: 10.1002/dneu.20360
[11]

Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, et al. 2004. Sortilin is essential for proNGF-induced neuronal cell death. Nature 427:843−848

doi: 10.1038/nature02319
[12]

Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, et al. 2010. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, Progranulin. Neuron 68:654−667

doi: 10.1016/j.neuron.2010.09.034
[13]

Nykjaer A, Willnow TE. 2012. Sortilin: a receptor to regulate neuronal viability and function. Trends in Neurosciences 35:261−270

doi: 10.1016/j.tins.2012.01.003
[14]

Goettsch C, Kjolby M, Aikawa E. 2018. Sortilin and its multiple roles in cardiovascular and metabolic diseases. Arteriosclerosis, Thrombosis, and Vascular Biology 38:19−25

doi: 10.1161/ATVBAHA.117.310292
[15]

Møller PL, Rohde PD, Winther S, Breining P, Nissen L, et al. 2021. Sortilin as a biomarker for cardiovascular disease revisited. Frontiers in Cardiovascular Medicine 8:652584

doi: 10.3389/fcvm.2021.652584
[16]

Rhost S, Hughes É, Harrison H, Rafnsdottir S, Jacobsson H, et al. 2018. Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion. Breast Cancer Research 20:137

doi: 10.1186/s13058-018-1060-5
[17]

Yang W, Wu PF, Ma JX, Liao MJ, Wang XH, et al. 2019. Sortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3β/β-catenin/twist pathway. Cell Death & Disease 10:208

doi: 10.1038/s41419-019-1449-9
[18]

Salasova A, Monti G, Andersen OM, Nykjaer A. 2022. Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer's disease. Molecular Neurodegeneration 17:74

doi: 10.1186/s13024-022-00576-2
[19]

Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, et al. 2007. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience 10:1449−1457

doi: 10.1038/nn2000
[20]

Santos AM, López-Sánchez N, Martín-Oliva D, de la Villa P, Cuadros MA, et al. 2012. Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS One 7:e36243

doi: 10.1371/journal.pone.0036243
[21]

Jakobsen TS, Østergaard JA, Kjolby M, Birch EL, Bek T, et al. 2023. Sortilin inhibition protects neurons from degeneration in the diabetic retina. Investigative Ophthalmology & Visual Science 64:8

doi: 10.1167/iovs.64.7.8
[22]

Staib-Lasarzik I, Gölz C, Bobkiewiecz W, Somnuke P, Sebastiani A, et al. 2024. Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice. Heliyon 10:e35198

doi: 10.1016/j.heliyon.2024.e35198
[23]

Gürgör P, Pallesen LT, Johnsen L, Ulrichsen M, de Jong IEM, et al. 2016. Neuronal death in the dorsal root ganglion after sciatic nerve injury does not depend on sortilin. Neuroscience 319:1−8

doi: 10.1016/j.neuroscience.2016.01.036
[24]

Suter TACS, Wang J, Meng H, He Z. 2021. Utilizing mouse optic nerve crush to examine CNS remyelination. STAR Protocols 2:100796

doi: 10.1016/j.xpro.2021.100796
[25]

Cameron EG, Xia X, Galvao J, Ashouri M, Kapiloff MS, et al. 2020. Optic nerve crush in mice to study retinal ganglion cell survival and regeneration. Bio-protocol 10:e3559

doi: 10.21769/BioProtoc.3559
[26]

Pang IH, Clark AF. 2020. Inducible rodent models of glaucoma. Progress in Retinal and Eye Research 75:100799

doi: 10.1016/j.preteyeres.2019.100799
[27]

Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, et al. 2017. QuPath: open source software for digital pathology image analysis. Scientific Reports 7:16878

doi: 10.1038/s41598-017-17204-5
[28]

Kalous A, Nangle MR, Anastasia A, Hempstead BL, Keast JR. 2012. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. Journal of Neurochemistry 122:523−536

doi: 10.1111/j.1471-4159.2012.07799.x
[29]

Richner M, Pallesen LT, Ulrichsen M, Poulsen ET, Holm TH, et al. 2019. Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Science Advances 5:eaav9946

doi: 10.1126/sciadv.aav9946
[30]

Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, et al. 2014. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorganic & Medicinal Chemistry Letters 24:177−180

doi: 10.1016/j.bmcl.2013.11.046
[31]

Malik I, Christensen S, Stavenhagen JB, Dietz GPH. 2018. Development of a cell-based assay to assess binding of the proNGF prodomain to sortilin. Cellular and Molecular Neurobiology 38:827−840

doi: 10.1007/s10571-017-0558-1
[32]

Harada C, Harada T, Nakamura K, Sakai Y, Tanaka K, et al. 2006. Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye. Developmental Biology 290:57−65

doi: 10.1016/j.ydbio.2005.08.051
[33]

Teng HK, Teng KK, Lee R, Wright S, Tevar S, et al. 2005. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of Neuroscience 25:5455−5463

doi: 10.1523/JNEUROSCI.5123-04.2005
[34]

Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. 2012. The molecular basis of retinal ganglion cell death in glaucoma. Progress in Retinal and Eye Research 31:152−181

doi: 10.1016/j.preteyeres.2011.11.002
[35]

Liu Y, McDowell CM, Zhang Z, Tebow HE, Wordinger RJ, et al. 2014. Monitoring retinal morphologic and functional changes in mice following optic nerve crush. Investigative Ophthalmology & Visual Science 55:3766−3774

doi: 10.1167/iovs.14-13895
[36]

Mysona BA, Zhao J, Bollinger KE. 2017. Role of BDNF/TrkB pathway in the visual system: therapeutic implications for glaucoma. Expert Review of Ophthalmology 12:69−81

doi: 10.1080/17469899.2017.1259566
[37]

Evans SF, Irmady K, Ostrow K, Kim T, Nykjaer A, et al. 2011. Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. Journal of Biological Chemistry 286:29556−29567

doi: 10.1074/jbc.M111.219675
[38]

Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, et al. 2005. Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. The Journal of Neuroscience 25:6156−6166

doi: 10.1523/JNEUROSCI.1017-05.2005
[39]

Yang M, Lim Y, Li X, Zhong JH, Zhou XF. 2011. Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. Journal of Biological Chemistry 286:16272−16284

doi: 10.1074/jbc.M110.195347
[40]

Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, et al. 2011. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nature Neuroscience 14:54−61

doi: 10.1038/nn.2689