[1]

Kongor JE, Owusu M, Oduro-Yeboah C. 2024. Cocoa production in the 2020s: challenges and solutions. CABI Agriculture and Bioscience 5:102

doi: 10.1186/s43170-024-00310-6
[2]

Rojo-Poveda O, Barbosa-Pereira L, Zeppa G, Stévigny C. 2020. Cocoa bean shell—a by-product with nutritional properties and biofunctional potential. Nutrients 12:1123

doi: 10.3390/nu12041123
[3]

Younes A, Karboune S, Liu L, Andreani ES, Dahman S. 2023. Extraction and characterization of cocoa bean shell cell wall polysaccharides. Polymers 15:745

doi: 10.3390/polym15030745
[4]

Hashimoto JC, Lima JC, Celeghini RMS, Nogueira AB, Efraim P, et al. 2018. Quality control of commercial cocoa beans (Theobroma cacao L.) by near-infrared spectroscopy. Food Analytical Methods 11:1510−1517

doi: 10.1007/s12161-017-1137-2
[5]

Slorach PC, Jeswani HK, Cuéllar-Franca R, Azapagic A. 2019. Environmental and economic implications of recovering resources from food waste in a circular economy. Science of the Total Environment 693:133516

doi: 10.1016/j.scitotenv.2019.07.322
[6]

Porto de Souza Vandenberghe L, Kley Valladares-Diestra K, Amaro Bittencourt G, Fátima Murawski de Mello A, Sarmiento Vásquez Z, et al. 2022. Added-value biomolecules' production from cocoa pod husks: a review. Bioresource Technology 344:126252

doi: 10.1016/j.biortech.2021.126252
[7]

Alvarez-Yanamango E, Obregon D, Ibañez A. 2025. A comprehensive review of the development of green extraction methods and encapsulation of theobromine from cocoa bean shells for nutraceutical applications. Food Engineering Reviews 17:1083−1104

doi: 10.1007/s12393-025-09425-6
[8]

Hernández-Hernández C, Morales-Sillero A, Fernández-Bolaños J, Bermúdez-Oria A, Morales AA, et al. 2019. Cocoa bean husk: industrial source of antioxidant phenolic extract. Journal of the Science of Food and Agriculture 99:325−333

doi: 10.1002/jsfa.9191
[9]

Aron PM, Kennedy JA. 2008. Flavan-3-ols: nature, occurrence and biological activity. Molecular Nutrition & Food Research 52:79−104

doi: 10.1002/mnfr.200700137
[10]

Barbosa-Pereira L, Belviso S, Ferrocino I, Rojo-Poveda O, Zeppa G. 2021. Characterization and classification of cocoa bean shells from different regions of Venezuela using HPLC-PDA-MS/MS and spectrophotometric techniques coupled to chemometric analysis. Foods 10:1791

doi: 10.3390/foods10081791
[11]

Nsor-Atindana J, Zhong F, Mothibe KJ, Bangoura ML, Lagnika C. 2012. Quantification of total polyphenolic content and antimicrobial activity of cocoa (Theobroma cacao L.) bean shells. Pakistan Journal of Nutrition 11:672−677

doi: 10.3923/pjn.2012.672.677
[12]

Osorio-Tobón JF. 2020. Recent advances and comparisons of conventional and alternative extraction techniques of phenolic compounds. Journal of Food Science and Technology 57:4299−4315

doi: 10.1007/s13197-020-04433-2
[13]

Joshi DR, Adhikari N. 2019. An overview on common organic solvents and their toxicity. Journal of Pharmaceutical Research International 28:1−18

doi: 10.9734/jpri/2019/v28i330203
[14]

Saini A, Kumar A, Panesar PS, Thakur A. 2022. Potential of deep eutectic solvents in the extraction of value‐added compounds from agro‐industrial by‐products. Applied Food Research 2:100211

doi: 10.1016/j.afres.2022.100211
[15]

Vanda H, Dai Y, Wilson EG, Verpoorte R, Choi YH. 2018. Green solvents from ionic liquids and deep eutectic solvents to natural deep eutectic solvents. Comptes Rendus Chimie 21:628−638

doi: 10.1016/j.crci.2018.04.002
[16]

Ma W, Tang M, Li S, Ma Y, Ling M, et al. 2025. The effect of hydrogen bonding strength in natural deep eutectic solvents on the extraction efficiency of polyphenols. Microchemical Journal 208:112379

doi: 10.1016/j.microc.2024.112379
[17]

Cabrera L, Xavier L, Zecchi B. 2024. Extraction of phenolic compounds with antioxidant activity from olive pomace using natural deep eutectic solvents: modelling and optimization by response surface methodology. Discover Food 4:29

doi: 10.1007/s44187-024-00100-z
[18]

Bagherian H, Zokaee Ashtiani F, Fouladitajar A, Mohtashamy M. 2011. Comparisons between conventional, microwave- and ultrasound-assisted methods for extraction of pectin from grapefruit. Chemical Engineering and Processing: Process Intensification 50:1237−1243

doi: 10.1016/j.cep.2011.08.002
[19]

Panzella L, Moccia F, Nasti R, Marzorati S, Verotta L, et al. 2020. Bioactive phenolic compounds from agri-food wastes: an update on green and sustainable extraction methodologies. Frontiers in Nutrition 7:60

doi: 10.3389/fnut.2020.00060
[20]

Lavilla I, Bendicho C. 2017. Fundamentals of ultrasound-assisted extraction. In Water Extraction of Bioactive Compounds, eds. González HD, Muñoz MJG. Amsterdam: Elsevier. pp. 291−316 doi: 10.1016/b978-0-12-809380-1.00011-5
[21]

Saini A, Panesar PS, Bera MB. 2019. Valorization of fruits and vegetables waste through green extraction of bioactive compounds and their nanoemulsions-based delivery system. Bioresources and Bioprocessing 6:26

doi: 10.1186/s40643-019-0261-9
[22]

Luo Y, Wu W, Chen D, Lin Y, Ma Y, et al. 2017. Optimization of simultaneous microwave/ultrasonic-assisted extraction of phenolic compounds from walnut flour using response surface methodology. Pharmaceutical Biology 55:1999−2004

doi: 10.1080/13880209.2017.1347189
[23]

Rebollo-Hernanz M, Cañas S, Taladrid D, Segovia Á, Bartolomé B, et al. 2021. Extraction of phenolic compounds from cocoa shell: Modeling using response surface methodology and artificial neural networks. Separation and Purification Technology 270:118779

doi: 10.1016/j.seppur.2021.118779
[24]

Mashuni, Hamid FH, Muzuni, Kadidae LO, Jahiding M, et al. 2020. The determination of total phenolic content of cocoa pod husk based on microwave-assisted extraction method. AIP Conference Proceedings 2243:030013

doi: 10.1063/5.0001364
[25]

Md Yusof AH, Abd Gani SS, Zaidan UH, Halmi MIE, Zainudin BH. 2019. Optimization of an ultrasound-assisted extraction condition for flavonoid compounds from cocoa shells (Theobroma cacao) using response surface methodology. Molecules 24:711

doi: 10.3390/molecules24040711
[26]

de Almeida Pontes PV, Ayumi Shiwaku I, Maximo GJ, Caldas Batista EA. 2021. Choline chloride-based deep eutectic solvents as potential solvent for extraction of phenolic compounds from olive leaves: extraction optimization and solvent characterization. Food Chemistry 352:129346

doi: 10.1016/j.foodchem.2021.129346
[27]

Kalompatsios D, Athanasiadis V, Palaiogiannis D, Lalas SI, Makris DP. 2022. Valorization of waste orange peels: aqueous antioxidant polyphenol extraction as affected by organic acid addition. Beverages 8:71

doi: 10.3390/beverages8040071
[28]

Tien NNT, Le NL, Khoi TT, Richel A. 2022. Optimization of microwave-ultrasound-assisted extraction (MUAE) of pectin from dragon fruit peels using natural deep eutectic solvents (NADES). Journal of Food Processing and Preservation 46:e16117

doi: 10.1111/jfpp.16117
[29]

Dai Y, Witkamp GJ, Verpoorte R, Choi YH. 2015. Tailoring properties of natural deep eutectic solvents with water to facilitate their applications. Food Chemistry 187:14−19

doi: 10.1016/j.foodchem.2015.03.123
[30]

Pal CBT, Jadeja GC. 2020. Microwave-assisted extraction for recovery of polyphenolic antioxidants from ripe mango (Mangifera indica L.) peel using lactic acid/sodium acetate deep eutectic mixtures. Food Science and Technology International 26:78−92

doi: 10.1177/1082013219870010
[31]

Tien NNT, Ha TH, Khuong BH, Thuan CM, Anh MNT, et al. 2026. Eco-compatible valorization of Arabica coffee pulp for total phenolic content: synergistic effect of microwave irradiation and sonication using a ternary acetate-based solvent. Journal of Food Measurement and Characterization 20:1998−2010

doi: 10.1007/s11694-025-03821-6
[32]

Razmavar S, Abdulla MA, Ismail SB, Hassandarvish P. 2014. Antibacterial activity of leaf extracts of Baeckea frutescens against methicillin-resistant Staphylococcus aureus. BioMed Research International 2014:521287

doi: 10.1155/2014/521287
[33]

Mellinas AC, Jiménez A, Garrigós MC. 2020. Optimization of microwave-assisted extraction of cocoa bean shell waste and evaluation of its antioxidant, physicochemical and functional properties. LWT 127:109361

doi: 10.1016/j.lwt.2020.109361
[34]

Marić M, Grassino AN, Zhu Z, Barba FJ, Brnčić M, et al. 2018. An overview of the traditional and innovative approaches for pectin extraction from plant food wastes and by-products: ultrasound-, microwaves-, and enzyme-assisted extraction. Trends in Food Science & Technology 76:28−37

doi: 10.1016/j.tifs.2018.03.022
[35]

Wang L, Weller CL. 2006. Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology 17:300−312

doi: 10.1016/j.tifs.2005.12.004
[36]

Nayak A, Shah A, Bhatt S, Bhushan B, Kumar A, et al. 2026. Ultrasound and microwave assisted extraction of bioactives from food wastes: an overview on their comparative analysis towards commercialization. Ultrasonics Sonochemistry 124:107712

doi: 10.1016/j.ultsonch.2025.107712
[37]

Zhang Q, De Oliveira Vigier K, Royer S, Jérôme F. 2012. Deep eutectic solvents: syntheses, properties and applications. Chemical Society Reviews 41:7108−7146

doi: 10.1039/C2CS35178A
[38]

Miguel Aguilera J. 2003. Solid-liquid extraction. In Extraction Optimization in Food Engineering, eds. Tzia C, Liadakis G. Boca Raton: CRC Press. pp. 51−70 doi: 10.1201/9780824756185.ch2
[39]

Maran JP, Swathi K, Jeevitha P, Jayalakshmi J, Ashvini G. 2015. Microwave-assisted extraction of pectic polysaccharide from waste mango peel. Carbohydrate Polymers 123:67−71

doi: 10.1016/j.carbpol.2014.11.072
[40]

Pasandide B, Khodaiyan F, Mousavi ZE, Hosseini SS. 2017. Optimization of aqueous pectin extraction from Citrus medica peel. Carbohydrate Polymers 178:27−33

doi: 10.1016/j.carbpol.2017.08.098
[41]

Maran JP, Priya B. 2014. Ultrasound-assisted extraction of polysaccharide from Nephelium lappaceum L. fruit peel. International Journal of Biological Macromolecules 70:530−536

doi: 10.1016/j.ijbiomac.2014.07.032
[42]

Vergara-Salinas JR, Pérez-Jiménez J, Torres JL, Agosin E, Pérez-Correa JR. 2012. Effects of temperature and time on polyphenolic content and antioxidant activity in the pressurized hot water extraction of deodorized thyme (Thymus vulgaris). Journal of Agricultural and Food Chemistry 60:10920−10929

doi: 10.1021/jf3027759
[43]

Biswas R, Sarkar A, Alam M, Roy M, Mahdi Hasan MM. 2023. Microwave and ultrasound-assisted extraction of bioactive compounds from Papaya: a sustainable green process. Ultrasonics Sonochemistry 101:106677

doi: 10.1016/j.ultsonch.2023.106677
[44]

Zheng X, Yin F, Liu C, Xu X. 2011. Effect of process parameters of microwave assisted extraction (MAE) on polysaccharides yield from pumpkin. Journal of Northeast Agricultural University (English Edition) 18:79−86

doi: 10.1016/S1006-8104(12)60014-2
[45]

Kashima M. 1999. Effects of catechins on superoxide and hydroxyl radical. Chemical And Pharmaceutical Bulletin 47:279−283

doi: 10.1248/cpb.47.279
[46]

Disca V, Travaglia F, Carini C, Coïsson JD, Cravotto G, et al. 2024. Improving the extraction of polyphenols from cocoa bean shells by ultrasound and microwaves: a comparative study. Antioxidants 13:1097

doi: 10.3390/antiox13091097
[47]

Choi D, Kang W, Park T. 2020. Anti-allergic and anti-inflammatory effects of undecane on mast cells and keratinocytes. Molecules 25:1554

doi: 10.3390/molecules25071554
[48]

Ben Taarit M, Msaada K, Hosni K, Chahed T, Marzouk B. 2010. Essential oil composition of Salvia verbenaca L. growing wild in Tunisia. Journal of Food Biochemistry 34:142−151

doi: 10.1111/j.1745-4514.2009.00270.x
[49]

Das J, Jha DK, Policegoudra RS, Mazumder AH, Das M, et al. 2012. Isolation and characterization of antidermatophytic bioactive molecules from Piper longum L. leaves. Indian Journal of Microbiology 52:624−629

doi: 10.1007/s12088-012-0303-x
[50]

He A, Chadha S, Saruchi, Kumar V. 2024. Phytocompound profiling and GC-MS analysis of Lantana camara leaf extract. Journal of the Indian Chemical Society 101:101379

doi: 10.1016/j.jics.2024.101379
[51]

Belwal T, Cravotto C, Ramola S, Thakur M, Chemat F, et al. 2022. Bioactive compounds from cocoa husk: extraction, analysis and applications in food production chain. Foods 11:798

doi: 10.3390/foods11060798
[52]

Ruesgas-Ramón M, Suárez-Quiroz ML, González-Ríos O, Baréa B, Cazals G, et al. 2020. Biomolecules extraction from coffee and cocoa by- and co-products using deep eutectic solvents. Journal of the Science of Food and Agriculture 100:81−91

doi: 10.1002/jsfa.9996
[53]

Vj D, Sivakumar SR, George M, Francis S. 2019. GC–MS analysis of bioactive compounds present in different extracts of rhizome of Curcuma aeruginosa Roxb. Journal of Drug Delivery and Therapeutics 9:13−19

doi: 10.22270/jddt.v9i2-s.2589
[54]

Kayaputri IL, Djali M, Sukri N, Fazaryasti RH. 2020. The antimicrobial effectiveness of cacao shell and cacao husk combination on inhibition of pathogenic bacteria in food products. IOP Conference Series: Earth and Environmental Science 443:012077

doi: 10.1088/1755-1315/443/1/012077
[55]

Rojo-Poveda O, Ribeiro SO, Anton-Sales C, Keymeulen F, Barbosa-Pereira L, et al. 2021. Evaluation of cocoa bean shell antimicrobial activity: a tentative assay using a metabolomic approach for active compound identification. Planta Medica 87:841−849

doi: 10.1055/a-1499-7829
[56]

Álvarez-Martínez FJ, Barrajón-Catalán E, Encinar JA, Rodríguez-Díaz JC, Micol V. 2020. Antimicrobial capacity of plant polyphenols against gram-positive bacteria: a comprehensive review. Current Medicinal Chemistry 27:2576−2606

doi: 10.2174/0929867325666181008115650
[57]

Sinsinwar S, Vadivel V. 2020. Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress. Applied Microbiology and Biotechnology 104:8279−8297

doi: 10.1007/s00253-020-10853-z
[58]

Yang X, Lan W, Sun X. 2023. Antibacterial and antioxidant properties of phenolic acid grafted chitosan and its application in food preservation: a review. Food Chemistry 428:136788

doi: 10.1016/j.foodchem.2023.136788