| [1] |
Feigin VL, Norrving B, Mensah GA. 2017. Global burden of stroke. |
| [2] |
Ding Q, Liu S, Yao Y, Liu H, Cai T, et al. 2022. Global, regional, and national burden of ischemic stroke, 1990–2019. |
| [3] |
Saini V, Guada L, Yavagal DR. 2021. Global epidemiology of stroke and access to acute ischemic stroke interventions. |
| [4] |
Brewer L, Horgan F, Hickey A, Williams D. 2013. Stroke rehabilitation: recent advances and future therapies. |
| [5] |
Dong X, Zhang T, Zhang C, Shang W, Zhang Y, et al. 2025. Traditional Chinese herbal medicines for the treatment of ischemic stroke in China. |
| [6] |
Law SK, Au DCT. 2026. A review of medicine and food homology on traditional Chinese medicine as functional food. |
| [7] |
Zhai X, Wang X, Wang L, Xiu L, Wang W, et al. 2020. Treating different diseases with the same method—a traditional Chinese medicine concept analyzed for its biological basis. |
| [8] |
Gao Y, Xie YM, Wang GQ, Cai YF, Shen XM, et al. 2022. Onset and recurrence characteristics of chinese patients with noncardiogenic ischemic stroke in Chinese medicine hospital. |
| [9] |
Zeng R, Zhang Y, Shi S, Long X, Zhang H, et al. 2024. Study on the mechanism of Panax notoginseng-Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin. |
| [10] |
Xiong Y, Chen L, Man J, Hu Y, Cui X. 2019. Chemical and bioactive comparison of Panax notoginseng root and rhizome in raw and steamed forms. |
| [11] |
Liu M, Cai Y, Li F, Wu Y, Zhang M, et al. 2022. Metabolomics and network pharmacological analysis to explore the mechanism of ginseng treatment for spleen-qi deficiency. |
| [12] |
Chen Y, Gao T, Bai J, Zhang W, Zhou Y, et al. 2024. Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice. |
| [13] |
Wang X, Wang S, Hu L. 2014. Neuroprotective effect of Panax notoginseng saponins and its main components. |
| [14] |
Kim KH, Lee D, Lee HL, Kim CE, Jung K, et al. 2018. Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions. |
| [15] |
Shi X, Yu W, Liu L, Liu W, Zhang X, et al. 2017. Panax notoginseng saponins administration modulates pro-/anti-inflammatory factor expression and improves neurologic outcome following permanent MCAO in rats. |
| [16] |
Jang KJ, Choi SH, Yu GJ, Hong SH, Chung YH, et al. 2016. Anti-inflammatory potential of total saponins derived from the roots of Panax ginseng in lipopolysaccharide-activated RAW 264.7 macrophages. |
| [17] |
Zhou L, Huang PP, Chen LL, Wang P. 2019. Panax notoginseng saponins ameliorate Aβ-mediated neurotoxicity in C. elegans through antioxidant activities. |
| [18] |
Houng NTT, Matsumoto K, Kasai R, Yamasaki K, Watanabe H. 1998. In vitro antioxidant activity of Vietnamese ginseng saponin and its components. |
| [19] |
Chen S, Liu J, Liu X, Fu Y, Zhang M, et al. 2011. Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes. |
| [20] |
Jang WY, Hwang JY, Cho JY. 2023. Ginsenosides from Panax ginseng as key modulators of NF-κB signaling are powerful anti-inflammatory and anticancer agents. |
| [21] |
Noll JM, Augello CJ, Kürüm E, Pan L, Pavenko A, et al. 2022. Spatial analysis of neural cell proteomic profiles following ischemic stroke in mice using high-plex digital spatial profiling. |
| [22] |
Liao J, Qian J, Fang Y, Chen Z, Zhuang X, et al. 2022. De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution. |
| [23] |
Xu J, Wang A, Meng X, Yalkun G, Xu A, et al. 2021. Edaravone dexborneol versus edaravone alone for the treatment of acute ischemic stroke: a phase III, randomized, double-blind, comparative trial. |
| [24] |
Feng S, Yang Q, Liu M, Li W, Yuan W, et al. 2011. Edaravone for acute ischaemic stroke. |
| [25] |
Li F, Zhao L, Shi Y, Liang J. 2020. Edaravone-loaded macrophage-derived exosomes enhance neuroprotection in the rat permanent middle cerebral artery occlusion model of stroke. |
| [26] |
Longa EZ, Weinstein PR, Carlson S, Cummins R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. |
| [27] |
Zhong K, Wang RX, Qian XD, Yu P, Zhu XY, et al. 2020. Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats. |
| [28] |
Ratz M, von Berlin L, Larsson L, Martin M, Westholm JO, et al. 2022. Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics. |
| [29] |
Scott EY, Safarian N, Casasbuenas DL, Dryden M, Tockovska T, et al. 2024. Integrating single-cell and spatially resolved transcriptomic strategies to survey the astrocyte response to stroke in male mice. |
| [30] |
Li H, Liu P, Zhang B, Yuan Z, Guo M, et al. 2023. Acute ischemia induces spatially and transcriptionally distinct microglial subclusters. |
| [31] |
Kim D, Paggi JM, Park C, Bennett C, Salzberg SL. 2019. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. |
| [32] |
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, et al. 2013. STAR: ultrafast universal RNA-seq aligner. |
| [33] |
Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, et al. 2015. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. |
| [34] |
Cheng J, Chen J, Liao J, Wang T, Shao X, et al. 2023. High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq. |
| [35] |
Liu C, Liu S, Xiong L, Zhang L, Li X, et al. 2021. Genistein-3'-sodium sulfonate attenuates neuroinflammation in stroke rats by down-regulating microglial M1 polarization through α7nAChR-NF-κB signaling pathway. |
| [36] |
Wang Y, Zhang S, Ni H, Zhang Y, Yan X, et al. 2021. Autophagy is involved in the neuroprotective effect of nicotiflorin. |
| [37] |
Deng M, Sun J, Peng L, Huang Y, Jiang W, et al. 2022. Scutellarin acts on the AR-NOX axis to remediate oxidative stress injury in a mouse model of cerebral ischemia/reperfusion injury. |
| [38] |
Liu H, Lu X, Hu Y, Fan X. 2020. Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy. |
| [39] |
Li W, Shi H, Wu X. 2025. A narrative review of Panax notoginseng: unique saponins and their pharmacological activities. |
| [40] |
Kim DH. 2012. Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. |
| [41] |
Carceller H, Hidalgo MR, Escartí MJ, Nacher J, de la Iglesia-Vayá M, et al. 2024. The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies. |
| [42] |
Murali M, Shivanandappa T. 2022. Endosulfan causes oxidative stress in the liver and brain that involves inhibition of NADH dehydrogenase and altered antioxidant enzyme status in rat. |
| [43] |
Kwak D, Park JH, Kim YH, Yoo HI. 2025. Decoding hippocampal subfield and glial responses in ischemia using single-cell transcriptomics. |