[1]

Sawicki T, Ruszkowska M, Danielewicz A, Niedźwiedzka E, Arłukowicz T, et al. 2021. A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers 13(9):2025

doi: 10.3390/cancers13092025
[2]

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, et al. 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA 71(3):209−249

doi: 10.3322/caac.21660
[3]

Li N, Lu B, Luo C, Cai J, Lu M, et al. 2021. Incidence, mortality, survival, risk factor and screening of colorectal cancer: a comparison among China, Europe, and northern America. Cancer Letters 522:255−268

doi: 10.1016/j.canlet.2021.09.034
[4]

Shinji S, Yamada T, Matsuda A, Sonoda H, Ohta R, et al. 2022. Recent advances in the treatment of colorectal cancer: a review. Nippon Ika Daigaku Zasshi 89(3):246−254

doi: 10.1272/jnms.JNMS.2022_89-310
[5]

Ju A, Wiltink L, Walker J, White K, Rutherford C. 2024. Supportive care interventions for managing gastrointestinal symptoms following treatment for colorectal cancer: a systematic review. Journal of Cancer Survivorship 18(5):1640−1647

doi: 10.1007/s11764-023-01403-3
[6]

Lewandowska A, Religioni U, Czerw A, Deptała A, Karakiewicz B, et al. 2022. Nutritional treatment of patients with colorectal cancer. International Journal of Environmental Research and Public Health 19(11):6881

doi: 10.3390/ijerph19116881
[7]

Qin X, Sun J, Liu M, Zhang L, Yin Q, et al. 2024. The effects of oral nutritional supplements interventions on nutritional status in patients undergoing colorectal cancer surgery: a systematic review. International Journal of Nursing Practice 30(3):e13226

doi: 10.1111/ijn.13226
[8]

Xie H, Wei L, Yuan G, Liu M, Tang S, et al. 2022. Prognostic value of prognostic nutritional index in patients with colorectal cancer undergoing surgical treatment. Frontiers in Nutrition 9:794489

doi: 10.3389/fnut.2022.794489
[9]

Zhu Y, Fan L, Geng X, Li J. 2021. The predictive value of the prognostic nutritional index to postoperative prognosis and nursing intervention measures for colorectal cancer. American Journal of Translational Research 13(12):14096−14101
[10]

Ding K, Liu C, Li L, Yang M, Jiang N, et al. 2023. Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism. Chinese Medical Journal 136(21):2521−2537

doi: 10.1097/CM9.0000000000002533
[11]

Chen F, Kang R, Liu J, Tang D. 2023. The ACSL4 network regulates cell death and autophagy in diseases. Biology 12(6):864

doi: 10.3390/biology12060864
[12]

Sha R, Xu Y, Yuan C, Sheng X, Wu Z, et al. 2021. Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy. eBioMedicine 71:103560

doi: 10.1016/j.ebiom.2021.103560
[13]

Hou J, Jiang C, Wen X, Li C, Xiong S, et al. 2022. ACSL4 as a potential target and biomarker for anticancer: from molecular mechanisms to clinical therapeutics. Frontiers in Pharmacology 13:949863

doi: 10.3389/fphar.2022.949863
[14]

Dai G, Wang D, Ma S, Hong S, Ding K, et al. 2022. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin. Phytomedicine 102:154149

doi: 10.1016/j.phymed.2022.154149
[15]

Yan L, Nakamura T, Casadei-Gardini A, Bruixola G, Huang YL, et al. 2021. Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review. Annals of Translational Medicine 9(21):1630

doi: 10.21037/atm-21-4528
[16]

Wang D, Hu X, Xiao L, Long G, Yao L, et al. 2021. Prognostic nutritional index and systemic immune-inflammation index predict the prognosis of patients with HCC. Journal of Gastrointestinal Surgery 25(2):421−427

doi: 10.1007/s11605-019-04492-7
[17]

Zhu X, Zhao Y, Ma F, Xuan L, Wu S. 2020. The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy. Scientific Reports 10:17373

doi: 10.1038/s41598-020-74525-8
[18]

Shimizu T, Taniguchi K, Asakuma M, Tomioka A, Inoue Y, et al. 2019. Lymphocyte-to-monocyte ratio and prognostic nutritional index predict poor prognosis in patients on chemotherapy for unresectable pancreatic cancer. Anticancer Research 39(4):2169−2176

doi: 10.21873/anticanres.13331
[19]

Xi Y, Xu P. 2021. Global colorectal cancer burden in 2020 and projections to 2040. Translational Oncology 14(10):101174

doi: 10.1016/j.tranon.2021.101174
[20]

Akabane M, Shindoh J, Kobayashi Y, Umino R, Kojima K, et al. 2021. Significance of preoperative nutritional status as a predictor for short-term and long-term outcomes of patients undergoing surgery for stage IV colorectal cancer. Langenbeck’s Archives of Surgery 406(7):2391−2398

doi: 10.1007/s00423-021-02255-0
[21]

Gholamalizadeh M, Behrad Nasab M, Ahmadzadeh M, Doaei S, Jonoush M, et al. 2022. The association among calorie, macronutrient, and micronutrient intake with colorectal cancer: a case-control study. Food Science & Nutrition 10(5):1527−1536

doi: 10.1002/fsn3.2775
[22]

Novelli IR, Araújo BAD, Grandisoli LF, Furtado ECG, Aguchiku EKN, et al. 2021. Nutritional counseling protocol for colorectal cancer patients after surgery improves outcome. Nutrition and Cancer 73(11−12):2278−2286

doi: 10.1080/01635581.2020.1819345
[23]

Tamai M, Kiuchi J, Kuriu Y, Arita T, Shimizu H, et al. 2021. Clinical impact of postoperative prognostic nutritional index in colorectal cancer patients undergoing adjuvant chemotherapy. American Journal of Cancer Research 11(10):4947−4955
[24]

Li J, Zhu N, Wang C, You L, Guo W, et al. 2023. Preoperative albumin-to-globulin ratio and prognostic nutritional index predict the prognosis of colorectal cancer: a retrospective study. Scientific Reports 13:17272

doi: 10.1038/s41598-023-43391-5
[25]

Lakemeyer L, Sander S, Wittau M, Henne-Bruns D, Kornmann M, et al. 2021. Diagnostic and prognostic value of CEA and CA19-9 in colorectal cancer. Diseases 9(1):21

doi: 10.3390/diseases9010021
[26]

Yang Y, Zhu T, Wang X, Xiong F, Hu Z, et al. 2022. ACSL3 and ACSL4, distinct roles in ferroptosis and cancers. Cancers 14(23):5896

doi: 10.3390/cancers14235896
[27]

Zhang J, Zou S, Fang L. 2023. Metabolic reprogramming in colorectal cancer: regulatory networks and therapy. Cell & Bioscience 13(1):25

doi: 10.1186/s13578-023-00977-w
[28]

Chen S, Ding P, Yang Y, Ma S, Guo H, et al. 2026. Multimodal digital biopsy for preoperative prediction of occult peritoneal metastasis in gastric cancer. npj Digital Medicine 9:107

doi: 10.1038/s41746-025-02268-9
[29]

Ding PA, Yang J, Guo H, Wu J, Wu H, et al. 2025. Multimodal artificial intelligence-based virtual biopsy for diagnosing abdominal lavage cytology-positive gastric cancer. Advanced Science 12(15):2411490

doi: 10.1002/advs.202411490
[30]

Ding P, Chen S, Guo H, Yang J, Fu Q, et al. 2025. Radiomics-based ensemble model predicts postoperative recurrence of gastric cancer. BMC Medicine 23(1):656

doi: 10.1186/s12916-025-04393-4
[31]

Ding PA, Yang J, Chen S, Guo H, Wu J, et al. 2025. Interpretable multimodal fusion model enhances postoperative recurrence prediction in gastric cancer. Advanced Science 12(43):e08190

doi: 10.1002/advs.202508190
[32]

Ding P, Chen S, Guo H, Yang S, Wang X, et al. 2026. A deep learning–based digital biopsy for predicting early recurrence in gastric cancer. Nature Communications 17:5220

doi: 10.1038/s41467-026-71347-6
[33]

Wang H, Xu H, Yang Y. 2024. Serum ACSL4 levels in prostate cancer patients and its relationship between patient prognosis: a prospective observational study. Medicine 103(40):e39119

doi: 10.1097/MD.0000000000039119
[34]

Feng J, Lu PZ, Zhu GZ, Hooi SC, Wu Y, et al. 2021. ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. Acta Pharmacologica Sinica 42(1):160−170

doi: 10.1038/s41401-020-0439-x
[35]

Tian X, Li S, Ge G. 2021. Apatinib promotes ferroptosis in colorectal cancer cells by targeting ELOVL6/ACSL4 signaling. Cancer Management and Research 13:1333−1342

doi: 10.2147/CMAR.S274631