| [1] |
Crasto W, Patel V, Davies MJ, Khunti K. 2021. Prevention of microvascular complications of diabetes. |
| [2] |
Vujosevic S, Aldington SJ, Silva P, Hernández C, Scanlon P, Peto T, et al. 2020. Screening for diabetic retinopathy: new perspectives and challenges. |
| [3] |
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ. 2021. Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy. |
| [4] |
Li H, Liu X, Zhong H, Fang J, Li X, et al. 2023. Research progress on the pathogenesis of diabetic retinopathy. |
| [5] |
Zhu JY, Yao W, Ni XS, Yao MD, Bai W, et al. 2023. Hyperglycemia-regulated tRNA-derived fragment tRF-3001a propels neurovascular dysfunction in diabetic mice. |
| [6] |
Dharmarajan S, Carrillo C, Qi Z, Wilson JM, Baucum AJ, et al. 2023. Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy. |
| [7] |
Lei Y, Liu Q, Chen B, Wu F, Li Y, et al. 2024. Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy. |
| [8] |
Simó R, Simó-Servat O, Bogdanov P, Hernández C. 2022. Diabetic retinopathy: role of neurodegeneration and therapeutic perspectives. |
| [9] |
Yıldızhan K, Bayir MH, Huyut Z, Altındağ F. 2025. Effect of Hesperidin on Lipid Profile, Inflammation and Apoptosis in Experimental Diabetes. |
| [10] |
Shi TF, Zhou Z, Jiang WJ, Huang TL, Si JQ, et al. 2024. Hyperglycemia-induced oxidative stress exacerbates mitochondrial apoptosis damage to cochlear stria vascularis pericytes via the ROS-mediated Bcl-2/CytC/AIF pathway. |
| [11] |
Chen S, Sun D, Zhang S, Xu L, Wang N, et al. 2024. TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia. |
| [12] |
Çiğ E, Yardımcı M, Çınar R, Yıldızhan K. 2026. Protective role of zingerone against high glucose-Induced retinal pigment epithelial cell damage through modulation of the TRPM2 channel pathway. |
| [13] |
Jelinek HF, Helf C, Khalaf K. 2021. Human SHC-transforming protein 1 and its isoforms p66shc: a novel marker for prediabetes. |
| [14] |
Liang Y, Lei Y, Du M, Liang M, Liu Z, et al. 2021. The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: integrative analysis of clinical and bioinformatics databases. |
| [15] |
Tatangelo V, Boncompagni G, Capitani N, Lopresti L, Manganaro N, et al. 2022. p66Shc deficiency in chronic lymphocytic leukemia promotes chemokine receptor expression through the ROS-dependent inhibition of NF-κB. |
| [16] |
Lebiedzinska-Arciszewska M, Pakula B, Bonora M, Missiroli S, Potes Y, et al. 2024. Distribution of the p66Shc adaptor protein among mitochondrial and mitochondria—associated membranes fractions in normal and oxidative stress conditions. |
| [17] |
Zhao MH, Hu J, Li S, Wu Q, Lu P. 2018. p66Shc expression in diabetic rat retina. |
| [18] |
Mishra M, Duraisamy AJ, Bhattacharjee S, Kowluru RA. 2019. Adaptor protein p66Shc: a link between cytosolic and mitochondrial dysfunction in the development of diabetic retinopathy. |
| [19] |
Shen C, Jiang Y, Lin J, He Y, Liu Y, et al. 2023. SIRT6 reduces the symptoms of premature ovarian failure and alleviates oxidative stress and apoptosis in granulosa cells by degrading p66SHC via H3K9AC. |
| [20] |
Wu RF, Liao C, Fu G, Hayenga HN, Yang K, et al. 2016. p66Shc couples mechanical signals to RhoA through focal adhesion kinase-dependent recruitment of p115-RhoGEF and GEF-H1. |
| [21] |
O'Leary F, Campbell M. 2023. The blood–retina barrier in health and disease. |
| [22] |
Dziedziak J, Zaleska-Żmijewska A, Szaflik JP, Cudnoch-Jędrzejewska A. 2022. Impact of arterial hypertension on the eye: a review of the pathogenesis, diagnostic methods, and treatment of hypertensive retinopathy. |
| [23] |
Li Y, Chen Q, Liu Y, Bi L, Jin L, et al. 2022. High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis. |
| [24] |
Gao X, Fan X, Yu X, Wang R, Zhang B, et al. 2025. p66shc exacerbates the progression of obstructive nephropathy through apoptosis, mitochondrial damage, and EMT. |
| [25] |
Biondi G, Marrano N, Borrelli A, Rella M, D'Oria R, et al. 2024. The p66Shc redox protein and the emerging complications of diabetes. |
| [26] |
ALTamimi JZ, AlFaris NA, AL-Farga AM, Alshammari GM, BinMowyna MN, et al. 2021. Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a. |
| [27] |
Mengozzi A, Costantino S, Paneni F, Duranti E, Nannipieri M, et al. 2022. Targeting SIRT1 rescues age- and obesity-induced microvascular dysfunction in ex vivo human vessels. |
| [28] |
Kumar S, Kim YR, Vikram A, Naqvi A, Li Q, et al. 2017. Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. |
| [29] |
Al Sabaani N. 2021. Exendin-4 inhibits high glucose-induced oxidative stress in retinal pigment epithelial cells by modulating the expression and activation of p66Shc. |
| [30] |
Sha Z, Yang Y, Liu R, Bao H, Song S, et al. 2022. Hepatic ischemia-reperfusion injury in mice was alleviated by rac1 inhibition – more than just ROS-inhibition. |
| [31] |
Wang Z, Xia P, Hu J, Huang Y, Zhang F, et al. 2021. LncRNA MEG3 alleviates diabetic cognitive impairments by reducing mitochondrial-derived apoptosis through promotion of FUNDC1-related mitophagy via Rac1-ROS axis. |
| [32] |
Ji L, Zhang X, Chen Z, Wang Y, Zhu H, et al. 2024. High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast. |
| [33] |
Zhu L, Huang R, Feng JR, Zhang M, Huang XJ, et al. 2025. Shexiang Tongxin Dropping Pills attenuate ischemic microvascular dysfunction via suppressing P66Shc-mediated mitochondrial respiration deficits. |
| [34] |
Onnis A, Cianfanelli V, Cassioli C, Samardzic D, Pelicci PG, et al. 2018. The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. |
| [35] |
Reed DK, Carter A, Dixit M, Arany I. 2017. p66shc-mediated toxicity of high-dose α-tocopherol in renal proximal tubule cells. |
| [36] |
Zhang M, Yang J, Ji K, He X, He T, et al. 2022. Inhibition of p66Shc attenuates retinal ischemia-reperfusion injury-induced damage by activating the Akt pathway. |
| [37] |
Mukerjee S, Gonzalez-Reymundez A, Lunt SY, Vazquez AI. 2020. DNA methylation and gene expression with clinical covariates explain variation in aggressiveness and survival of pancreatic cancer patients. |
| [38] |
Bashir M, Kirmani D, Bhat HF, Baba RA, Hamza R, et al. 2010. P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers. |
| [39] |
Park YJ, Lee YJ, Kim SH, Joung DS, Kim BJ, et al. 2008. Ghrelin enhances the proliferating effect of thyroid stimulating hormone in FRTL-5 thyroid cells. |
| [40] |
Patrussi L, Capitani N, Baldari CT. 2020. P66Shc: a pleiotropic regulator of B cell trafficking and a gatekeeper in chronic lymphocytic leukemia. |