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MAP  >  Gastrointestinal Tumors
2021 Volume 8
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REVIEW ARTICLE   Open Access    

The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin Ⅱ Type 1 Receptors: Need for Novel Treatment Strategies

  • a.

    Kidney Transplantation Complications Research Center, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

  • b.

    Department of Urology, Kashani Academic Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • c.

    Department of Surgery, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • d.

    Brighton & Sussex Medical School, Division of Medical Education, Brighton, UK

  • e.

    Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

  • f.

    Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

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  • Background: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions.
    Summary: Addressing the pathological causes of PSAB, the potential role of local angiotensin Ⅱ/angiotensin Ⅱ type 1 receptors (AngII/AT1R), may help to prevent this problem.
    Key Message: The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.

  • Cite this article

    Mahmood Tavakkoli, Saeed Aali, Borzoo Khaledifar, Gordon A. Ferns, Majid Khazaei, Kiavash Fekri, Mohammad-Hassan Arjmand. 2021. The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin Ⅱ Type 1 Receptors: Need for Novel Treatment Strategies. Gastrointestinal Tumors. 8:514614 doi: 10.1159/000514614
    Mahmood Tavakkoli, Saeed Aali, Borzoo Khaledifar, Gordon A. Ferns, Majid Khazaei, Kiavash Fekri, Mohammad-Hassan Arjmand. 2021. The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin Ⅱ Type 1 Receptors: Need for Novel Treatment Strategies. Gastrointestinal Tumors. 8:514614 doi: 10.1159/000514614
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Review Article   Open Access    

The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin Ⅱ Type 1 Receptors: Need for Novel Treatment Strategies

  • a.

    Kidney Transplantation Complications Research Center, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

  • b.

    Department of Urology, Kashani Academic Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • c.

    Department of Surgery, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • d.

    Brighton & Sussex Medical School, Division of Medical Education, Brighton, UK

  • e.

    Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

  • f.

    Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • Received: 13 November 2020
  • Accepted: 17 January 2021
  • Published online: 31 March 2021
Gastrointestinal Tumors  8,  Article number: 10.1159/000514614  (2021)  |  Cite this article

Abstract: 

Background: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions.
Summary: Addressing the pathological causes of PSAB, the potential role of local angiotensin Ⅱ/angiotensin Ⅱ type 1 receptors (AngII/AT1R), may help to prevent this problem.
Key Message: The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.

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    Cite this article
    Mahmood Tavakkoli, Saeed Aali, Borzoo Khaledifar, Gordon A. Ferns, Majid Khazaei, Kiavash Fekri, Mohammad-Hassan Arjmand. 2021. The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin Ⅱ Type 1 Receptors: Need for Novel Treatment Strategies. Gastrointestinal Tumors. 8:514614 doi: 10.1159/000514614
    Mahmood Tavakkoli, Saeed Aali, Borzoo Khaledifar, Gordon A. Ferns, Majid Khazaei, Kiavash Fekri, Mohammad-Hassan Arjmand. 2021. The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin Ⅱ Type 1 Receptors: Need for Novel Treatment Strategies. Gastrointestinal Tumors. 8:514614 doi: 10.1159/000514614
    shu

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