Search
  • All Journals
Advanced Search
Search articles by Title, Author, Keywords, DOI
Submit Manuscript
0.7Impact Factor
Advanced Search
MAP  >  Gastrointestinal Tumors
2020 Volume 7
Article Contents
Next Previous
RESEARCH ARTICLE   Open Access    

Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer

  • a.

    Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran

  • b.

    Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • c.

    Department of Bioengineering and Technology (GUIST), Gauhati University, Guwahati, India

More Information
  • Corresponding authors: Shahrokh Iravani AJA Cancer Epidemiology Research and Treatment Center (AJA-CERTC) AJA University of Medical Sciences Shahid Etemadzadeh St., Tehran 1411718541 (Iran) shahrokh.iravani1@gmail.com;  Azim Mehrvar Mahak Hematology Oncology Research Center (Mahak-HORC) Mahak Hospital, Tehran 1956993461 (Iran) DRAZIMMEHRVAR@yahoo.com
  • Background: Cancer is one of the major causes of death worldwide and the third leading cause of death in Iran. One of the proteins that are considered having anticancer effects is the adiponectin hormone. Adiponectin leads to programmed cell death, prevents cell growth and proliferation, and increases the expression levels of BCL2.
    Aim: The aim of this study was to assay the expression of adiponectin receptors (AdipoR1 and AdipoR2) genes in gastric cancer patients.
    Materials and Methods: In this case-control study, 42 gastric cancer patients and 52 volunteers as healthy controls were enrolled. Total RNA was extracted. cDNA was synthesized by the reverse transcription method, and expression analysis was performed by real-time PCR. The serum level of adiponectin was also measured by ELISA.
    Results: The expression of both AdipoR1 and AdipoR2 was significantly higher than the control group (p = 0.02). Serum adiponectin was significantly lower in gastric cancer cases when compared with normal controls (p = 0.03).
    Conclusion: We found that expression level of AdipoR1 and AdipoR2 is strongly higher; however, the level of circulating adiponectin is lower in gastric cancer. Our study suggests that the expression of AdipoR1 and AdipoR2, besides the low level of adiponectin, may play an important role in the development and/or progression of gastric cancer.

  • Cite this article

    Morteza Kordafshari, Mahyar Nourian, Narjes Mehrvar, Hassan Jalaeikhoo, Aida Etemadi, Ali Reza Khoshdel, Mohammad Ghaznavi Idris, Shahrokh Iravani, Azim Mehrvar. 2020. Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer. Gastrointestinal Tumors. 7:342 doi: 10.1159/000510342
    Morteza Kordafshari, Mahyar Nourian, Narjes Mehrvar, Hassan Jalaeikhoo, Aida Etemadi, Ali Reza Khoshdel, Mohammad Ghaznavi Idris, Shahrokh Iravani, Azim Mehrvar. 2020. Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer. Gastrointestinal Tumors. 7:342 doi: 10.1159/000510342
    shu

Figures(2)  /  Tables(2)

Download PDF

Article Metrics

Article views(684) PDF downloads(518)

Other Articles By Authors

Research Article   Open Access    

Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer

  • a.

    Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran

  • b.

    Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • c.

    Department of Bioengineering and Technology (GUIST), Gauhati University, Guwahati, India

  • Corresponding authors: Shahrokh Iravani AJA Cancer Epidemiology Research and Treatment Center (AJA-CERTC) AJA University of Medical Sciences Shahid Etemadzadeh St., Tehran 1411718541 (Iran) shahrokh.iravani1@gmail.com;  Azim Mehrvar Mahak Hematology Oncology Research Center (Mahak-HORC) Mahak Hospital, Tehran 1956993461 (Iran) DRAZIMMEHRVAR@yahoo.com
  • Received: 01 March 2020
  • Accepted: 17 July 2020
  • Published online: 16 September 2020
Gastrointestinal Tumors  7,  Article number: 10.1159/000510342  (2020)  |  Cite this article

Abstract: 

Background: Cancer is one of the major causes of death worldwide and the third leading cause of death in Iran. One of the proteins that are considered having anticancer effects is the adiponectin hormone. Adiponectin leads to programmed cell death, prevents cell growth and proliferation, and increases the expression levels of BCL2.
Aim: The aim of this study was to assay the expression of adiponectin receptors (AdipoR1 and AdipoR2) genes in gastric cancer patients.
Materials and Methods: In this case-control study, 42 gastric cancer patients and 52 volunteers as healthy controls were enrolled. Total RNA was extracted. cDNA was synthesized by the reverse transcription method, and expression analysis was performed by real-time PCR. The serum level of adiponectin was also measured by ELISA.
Results: The expression of both AdipoR1 and AdipoR2 was significantly higher than the control group (p = 0.02). Serum adiponectin was significantly lower in gastric cancer cases when compared with normal controls (p = 0.03).
Conclusion: We found that expression level of AdipoR1 and AdipoR2 is strongly higher; however, the level of circulating adiponectin is lower in gastric cancer. Our study suggests that the expression of AdipoR1 and AdipoR2, besides the low level of adiponectin, may play an important role in the development and/or progression of gastric cancer.

  • About this article
    Cite this article
    Morteza Kordafshari, Mahyar Nourian, Narjes Mehrvar, Hassan Jalaeikhoo, Aida Etemadi, Ali Reza Khoshdel, Mohammad Ghaznavi Idris, Shahrokh Iravani, Azim Mehrvar. 2020. Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer. Gastrointestinal Tumors. 7:342 doi: 10.1159/000510342
    Morteza Kordafshari, Mahyar Nourian, Narjes Mehrvar, Hassan Jalaeikhoo, Aida Etemadi, Ali Reza Khoshdel, Mohammad Ghaznavi Idris, Shahrokh Iravani, Azim Mehrvar. 2020. Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer. Gastrointestinal Tumors. 7:342 doi: 10.1159/000510342
    shu

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return