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MAP  >  Gastrointestinal Tumors
2021 Volume 8
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REVIEW ARTICLE   Open Access    

The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy

  • a.

    Division of Medical Education, Brighton & Sussex Medical School, Brighton, UK

  • b.

    Department of Microbiology and Immunology, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • c.

    Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • d.

    Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • e.

    Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

More Information
  • Background: Changes in cell metabolism are a well-known feature of some cancers, and this may be involved in the etiology of tumor formation and progression, as well as tumor heterogeneity. These changes may affect fatty acid metabolism and glycolysis and are required to provide the increase in energy necessary for the high rate of proliferation of cancer cells. Gastrointestinal cancers remain a difficult-to-treat cancer, particularly as they are usually diagnosed at a late stage of disease and are associated with poor outcomes.
    Summary: Recently, the changes in the metabolic pathways, including the expression of the rate-limiting enzymes involved, have been considered to be a potential target for therapy for gastrointestinal tumors.
    Key Message: A combination of routine chemotherapy drugs with metabolic inhibitors may improve the effectiveness of treatment.

  • Cite this article

    Gordon A. Ferns, Milad Shahini Shams Abadi, Ahmad Raeisi, Mohammad-Hassan Arjmand. 2021. The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy. Gastrointestinal Tumors. 8:517771 doi: 10.1159/000517771
    Gordon A. Ferns, Milad Shahini Shams Abadi, Ahmad Raeisi, Mohammad-Hassan Arjmand. 2021. The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy. Gastrointestinal Tumors. 8:517771 doi: 10.1159/000517771
    shu

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Review Article   Open Access    

The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy

  • a.

    Division of Medical Education, Brighton & Sussex Medical School, Brighton, UK

  • b.

    Department of Microbiology and Immunology, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • c.

    Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • d.

    Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • e.

    Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

  • Received: 08 April 2021
  • Accepted: 10 June 2021
  • Published online: 05 August 2021
Gastrointestinal Tumors  8,  Article number: 10.1159/000517771  (2021)  |  Cite this article

Abstract: 

Background: Changes in cell metabolism are a well-known feature of some cancers, and this may be involved in the etiology of tumor formation and progression, as well as tumor heterogeneity. These changes may affect fatty acid metabolism and glycolysis and are required to provide the increase in energy necessary for the high rate of proliferation of cancer cells. Gastrointestinal cancers remain a difficult-to-treat cancer, particularly as they are usually diagnosed at a late stage of disease and are associated with poor outcomes.
Summary: Recently, the changes in the metabolic pathways, including the expression of the rate-limiting enzymes involved, have been considered to be a potential target for therapy for gastrointestinal tumors.
Key Message: A combination of routine chemotherapy drugs with metabolic inhibitors may improve the effectiveness of treatment.

  • About this article
    Cite this article
    Gordon A. Ferns, Milad Shahini Shams Abadi, Ahmad Raeisi, Mohammad-Hassan Arjmand. 2021. The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy. Gastrointestinal Tumors. 8:517771 doi: 10.1159/000517771
    Gordon A. Ferns, Milad Shahini Shams Abadi, Ahmad Raeisi, Mohammad-Hassan Arjmand. 2021. The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy. Gastrointestinal Tumors. 8:517771 doi: 10.1159/000517771
    shu

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